Normal or High Polyphenol Concentration in Orange Juice Affects Antioxidant Activity, Blood Pressure, and Body Weight in Obese or Overweight Adults

Rangel-Huerta, Óscar Daniel; Aguilera, Concepción M.; Martin, María Victoria; Soto, Maria J; Rico, María C; Vallejo, Fernando; Tomás-Barberán, Francisco A.; Perez-de-la-Cruz, Antonio J; Gil, Ángel; Mesa, María Dolores

doi:10.3945/jn.115.213660

Cited by 116 publications

(125 citation statements)

References 48 publications

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“…They cover a wide range of metabolic activities and have many functions in the body: antioxidant, antiinflammatory, platelet aggregation inhibitory and immunological; and they can act at different molecular levels. Thus, the consumption of phenolic compounds is associated with health benefits (Rangel-Huerta et al, 2015). Also, several studies in plants report on their antioxidant capacity.…”

Section: Author(s) Agree That This Article Remain Permanently Open Acmentioning

confidence: 99%

Phenolic profile and antioxidant capacity of Cnidoscolus chayamansa and Cnidoscolus aconitifolius: A review

GuzmÃ¡n-Maldonado¹

2017

J. Med. Plants Res.

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Research into ancient cultures has yielded a large body of evidence on the use of medicinal plants for preventive and/or therapeutic purposes. Such plants may have many metabolic activities and functions in the body-antioxidant, anti-inflammatory, platelet aggregation inhibitory and immunological and they can act at different molecular levels. This work offers a comprehensive review of research into the phenolic profile and antioxidant capacity of a plant used since the pre-Columbian era, native to southeast Mexico, commonly known as "chaya". The most prevalent phytochemicals in this plant are its phenolic compounds, and their antioxidant capacity is responsible for many of its health benefits, specifically in controlling chronic diseases. In the chaya leaf, there is a general trend toward the presence of different phenolic groups, such as coumarin, flavonoids, phenols, tannins, anthraquinones and flobotanins in aqueous and alcoholic extracts. Aside from environmental factors, there are differences in the ways samples are treated before the extraction process, such as the treatment type and the drying conditions. There are also differences in the solvents used and in the methods of extraction and concentration of compounds. Finally, a diversity of techniques is used, and even the data are quantified and expressed differently. Chaya has great potential for production as food and as a medicinal plant, but much more research is needed on the composition of its leaf and the biological effects of its components.

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Section: Author(s) Agree That This Article Remain Permanently Open Acmentioning

confidence: 99%

Phenolic profile and antioxidant capacity of Cnidoscolus chayamansa and Cnidoscolus aconitifolius: A review

GuzmÃ¡n-Maldonado¹

2017

J. Med. Plants Res.

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“…Although there is scientific evidence showing that different (poly)phenol levels can affect the magnitude of health outcomes [12,[24][25][26][27][28][29], most of these studies included only two levels of (poly)phenol amounts, limiting the evaluation of dose-response relationships. Furthermore, most studies highlight the health benefits without investigating (poly)phenol bioavailability in a dose-response manner, so it is crucial to understand how (poly)phenol dosage can affect the metabolism and disposition of these compounds in humans.…”

Section: Introductionmentioning

confidence: 99%

Bioavailability of wild blueberry (poly)phenols at different levels of intake

Rodriguez-Mateos

Feliciano

Cifuentes-Gomez

et al. 2016

JBR

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Abstract. BACKGROUND:Data from human intervention studies have highlighted potential cardiovascular benefits of blueberry (poly)phenols. However, such biological effects are dependent on their bioavailability and, as such, information on the absorption, metabolism and excretion of such compounds is necessary. OBJECTIVE: To investigate whether the bioavailability of blueberry (poly)phenols is intake-dependent, a group of nine healthy volunteers consumed three wild blueberry drinks containing 766 mg (lower), 1278 mg (medium) and 1791 mg (higher) total (poly)phenols, corresponding to 34, 56 and 80 g, respectively, freeze-dried blueberry powder. METHODS: Plasma levels of (poly)phenol metabolites were assessed at baseline and at 1, 2, 4 and 6 hours post-consumption, using UPLC-Q-TOF mass spectrometry. RESULTS: Twenty-three phenolic acid metabolites were quantified in plasma after blueberry consumption. Increases in plasma (poly)phenol metabolites were observed in all the interventions tested. The area under the curve of the concentration over time (AUC) significantly increased when comparing the lower and higher (poly)phenol interventions. Linear doseresponse regressions were obtained for 11 metabolites, while the plasma concentration of the remaining 12 metabolites was not affected by increasing amounts of (poly)phenols in the blueberry interventions. CONCLUSION: Absorption and metabolism of blueberry (poly)phenols are not exclusively intake-dependent at the amounts tested, evidencing a complex metabolic fate of these compounds.

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“…Similar to phenolic compounds, carotenoids indirectly attenuate pro-inflammatory cytokines by their direct action on NF-κβ, an activator of many pro-inflammatory genes including those encoding inducible nitric oxide synthase, cyclooxygenase-2, TNF-α, IL-1β, and IL-6 [28]. Other ingredients known to have anti-inflammatory effects in this product include vitamins A, C, E, K, N-acetyl-L-cysteine, minerals such as zinc and selenium, and other cofactors such as coenzyme Q10 [29][30][31][32]. Thus, the positive changes we found in several pro-and anti-inflammatory cytokines would support the efficacy of Healthycell.…”

Section: Discussionmentioning

confidence: 99%

“…This product includes a wide range of nutrients and phytochemicals that are known to have anti-inflammatory effects, including resveratrol complex [21], L-arginine and L-citrulline [22], coenzyme Q10 [23], phenolic acids [24][25][26], flavonoids [27], carotenoids [28], and several vitamins and minerals [29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

A double-blind, randomized trial on the effect of a broad-spectrum dietary supplement on key biomarkers of cellular aging in healthy adults

2016

J Clin Transl Res

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Background and Aim: Nutritional approaches that ameliorate cellular senescence may have the potential to counteract the effects of chronic disease. This study will investigate the effect of the Healthycell dietary supplement on markers of inflammation, oxidative stress, and DNA damage. Methods:Thirty adults between the ages of 18 and 55 were enrolled and randomly assigned to one of the two study conditions (n = 15 Healthycell and n = 15 placebo). Subjects participated in a four-week intervention and were assessed at baseline, four weeks, and six weeks (after a two-week washout period). Results Conclusions:Our findings show an improved inflammatory profile and decreased DNA damage. Additionally, the efficacy of Healthycell was primarily in older adults, where the processes that cause or are associated with cell senescence are more predominant.Relevance for patients: Healthycell may help to counteract the inflammatory effects of aging that lead to both cell senescence and the multitude of age-related chronic diseases. Keywords:dietary supplement DNA damage inflammation oxidative stress older adults senescence 136

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Normal or High Polyphenol Concentration in Orange Juice Affects Antioxidant Activity, Blood Pressure, and Body Weight in Obese or Overweight Adults

Cited by 116 publications

References 48 publications

Phenolic profile and antioxidant capacity of Cnidoscolus chayamansa and Cnidoscolus aconitifolius: A review

Phenolic profile and antioxidant capacity of Cnidoscolus chayamansa and Cnidoscolus aconitifolius: A review

Bioavailability of wild blueberry (poly)phenols at different levels of intake

A double-blind, randomized trial on the effect of a broad-spectrum dietary supplement on key biomarkers of cellular aging in healthy adults

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