Normal pituitary hormone response to thyrotrophin and gonadotrophin releasing hormones in subjects exposed to elemental mercury vapour.

Erfurth, Eva Marie; Schütz, Andrejs; Nilsson, Astrid; Barregård, Lars; Skerfving, Staffan

doi:10.1136/oem.47.9.639

Cited by 20 publications

(15 citation statements)

References 30 publications

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“…The present data support the earlier findings indicating that methylmercury intake through fish is a major source of mercury exposure in the Swedish population. The mercury concentrations were in accordance with those found in other studies of Swedes, by use of the same (or similar) analytical technique (33,35,36,39, and Schiitz et al, unpublished report).…”

Section: Discussionsupporting

confidence: 79%

Fish consumption and exposure to persistent organochlorine compounds, mercury, selenium and methylamines among Swedish fishermen

Svensson¹,

Nilsson²,

Jonsson³

et al. 1995

Scand J Work Environ Health

Self Cite

136

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Section: Discussionsupporting

confidence: 79%

Fish consumption and exposure to persistent organochlorine compounds, mercury, selenium and methylamines among Swedish fishermen

Svensson¹,

Nilsson²,

Jonsson³

et al. 1995

Scand J Work Environ Health

Self Cite

136

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“…Some research suggests Hg-induced endocrine disruption in animals (Hontela et al 1992) and humans (Langworth et al 1990; Erfurth et al 1990); however, we are not aware of research on the potential effects of Hg on cortisol levels. To determine if Hg exposure disrupts endocrine function in children, saliva was collected at four points in the day and cortisol levels were measured.…”

Section: Resultsmentioning

confidence: 96%

“…Similarly, the cortisol levels in yellow perch and northern pike following capture stress were reduced in populations exposed to a set of environmental pollutants including MeHg (Hontela et al 1992). While human adult populations have not revealed a significant association between elemental Hg exposure and endocrine functioning (Langworth et al 1990; Erfurth et al 1990), research in this field is limited. As children are presumed to be more sensitive than adults to the effects of environmental toxicants (Faustman et al 2000), such effects might be evident in children in the absence of any observable effects in adults.…”

Section: Introductionmentioning

confidence: 99%

Fish consumption, low-level mercury, lipids, and inflammatory markers in children

Gump

MacKenzie

Dumas

et al. 2012

Environmental Research

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There is considerable evidence that consuming fish has numerous health benefits, including a reduced risk of cardiovascular disease. However, fish is also the primary source of human exposure to mercury (Hg). In a cross-sectional study of 9–11 year old children (N = 100), we measured fish consumption, blood lipids, total blood Hg, diurnal salivary cortisol (4 samples collected throughout the day), and performed a proteomic analysis of serum proteins using spectral count shotgun proteomics. Children that consumed fish had a significantly more atheroprotective lipid profile but higher levels of blood Hg relative to children that did not consume fish. Although the levels of blood Hg were very low in these children (M = 0.77 μg/L; all but 1 participant had levels below 3.27 μg/L), increasing blood Hg was significantly associated with blunted diurnal cortisol levels. Blood Hg was also significantly associated with acute-phase proteins suggesting systemic inflammation, and several of these proteins were found to significantly reduce the association between Hg and diminished cortisol when included in the model. This study of a pediatric population is the first to document an association between blood Hg, systemic inflammation, and endocrine disruption in humans, in a pediatric sample. Without a better understanding of the long-term consequences of an atheroprotective lipid profile relative to blunted diurnal cortisol and systemic inflammation, a determination of the risk-benefit ratio for fish consumption by children is not possible.

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“…Hence, xenobiotics that are agonists or antagonists of these compounds have the potential to modify GnRH release, thus interfering with pituitary communication. Some evidence for this has been seen in rats with neonatal exposure to DES [Faber et al, 1991] and in rats exposed to chlordimeform [Goldman et al, 1990], but not in men exposed to elemental mercury vapor [Erfurth et al, 1990].…”

Section: Possible Biological Mechanismsmentioning

confidence: 97%

Petrochemical exposure and menstrual disturbances

Thurston

Ryan

Christiani³

et al. 2000

Am. J. Ind. Med.

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Normal pituitary hormone response to thyrotrophin and gonadotrophin releasing hormones in subjects exposed to elemental mercury vapour.

Cited by 20 publications

References 30 publications

Fish consumption and exposure to persistent organochlorine compounds, mercury, selenium and methylamines among Swedish fishermen

Fish consumption and exposure to persistent organochlorine compounds, mercury, selenium and methylamines among Swedish fishermen

Fish consumption, low-level mercury, lipids, and inflammatory markers in children

Petrochemical exposure and menstrual disturbances

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