Normal pressure hydrocephalus in a case of schizophrenia

Agrawal, Amit; Tiwari, Ashutosh; Tiple, Prashant; Chauhan, Mahendra; Nagarale, Manda

doi:10.4103/0019-5545.104833

Cited by 5 publications

(4 citation statements)

References 4 publications

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“…apathy to psychotic symptoms, 10-23 but SCZ as a comorbid condition has not been previously systematically analyzed; SCZ or psychotic symptoms accompanied by iNPH have been reported infrequently in the literature during the past 4 decades (Table 1 ), 11 , 14-24 the majority being case reports. 15-18 , 21-23 However, the latest prospective study indicated an increased prevalence of iNPH in older patients with SCZ (5/24, 24%) in a highly selected hospital population. 14 The prevalence of psychotic symptoms or SCZ in patients with iNPH has been estimated to be low.…”

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confidence: 99%

Prevalence of Schizophrenia in Idiopathic Normal Pressure Hydrocephalus

et al. 2018

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SCZ seems to occur 3 times more frequently among iNPH patients compared to the general aged population in Finland. The outcome of the treatment was not affected by comorbid SCZ and therefore iNPH patients suffering from comorbid SCZ should not be left untreated. These results merit validation in other populations. In addition, further research towards the potential connection between these chronic conditions is warranted.

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confidence: 99%

Prevalence of Schizophrenia in Idiopathic Normal Pressure Hydrocephalus

et al. 2018

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“…Common and serious comorbidities include metabolic syndrome [2] caused by secondgeneration antipsychotics [3] and/or cognitive impairment that leads to problems with adherence to those treatments [4]. To our knowledge, only limited studies have mentioned idiopathic normal pressure hydrocephalus (iNPH) among SZ patients, including one retrospective study [5], two case reports [6,7], and one theoretical paper [8].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of possible idiopathic normal pressure hydrocephalus in older inpatients with schizophrenia: a replication study

et al. 2020

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Background: We recently reported that older patients with schizophrenia (SZ) show possible idiopathic normal pressure hydrocephalus (iNPH) more frequently than the general population. In this study, we estimated the prevalence of iNPH in a larger number of older SZ patients and explored useful examination values for diagnosis in the SZ population. Methods: We enrolled older inpatients with SZ (n = 39, mean age = 68.6 ± 7.7 years) from several psychiatric hospitals in Ehime, Japan and acquired brain imaging data using computed tomography. We evaluated three iNPH symptoms (dementia, gait disturbance, and urinary incontinence). In addition, we combined these data with our previous data to elucidate the relationship between iNPH and characteristics of SZ symptoms. Results: In total, five (12.8%) patients were diagnosed with possible iNPH. Evans' index for patients with iNPH was significantly higher than for those without iNPH (p = 0.002). The number of disproportionately enlarged subarachnoid space hydrocephalus (DESH) findings was significantly higher in patients with iNPH than in those without iNPH (p < 0.001). Using combined data, Drug-Induced Extra-pyramidal Symptoms Scale (DIEPSS) subscales of gait and bradykinesia showed an increasing trend in the SZ with iNPH group. Conclusions: We reconfirmed that older inpatients with SZ experienced possible iNPH more frequently than the general population. We should pay attention to the DIEPSS subscales of gait and bradykinesia and DESH findings in addition to the three main symptoms of iNPH and Evans' index so as to not miss SZ patients with iNPH.

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“…Faulty craniospinal hydrodynamics may also play a role in neurodegenerative diseases such as Alzheimer [ 91 – 97 ], Parkinson [ 98 – 101 ], multiple sclerosis [ 102 – 108 ], dementia [ 109 – 113 ], and motor neuron diseases [ 114 – 121 ]. Lastly, faulty craniospinal hydrodynamics may play a role in migraines [ 122 – 128 ], silent-strokes [ 128 – 130 ], seizures [ 131 – 134 ], psychosis [ 135 – 145 ], depression [ 146 – 148 ], and mania [ 149 – 153 ]. The aim of this paper is to stimulate further research into the role of the craniocervical junction and faulty craniospinal hydrodynamics in neurodegenerative and other neurological conditions that will lead to prevention and more effective treatments.…”

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confidence: 99%

The Role of the Craniocervical Junction in Craniospinal Hydrodynamics and Neurodegenerative Conditions

Flanagan

2015

Neurology Research International

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The craniocervical junction (CCJ) is a potential choke point for craniospinal hydrodynamics and may play a causative or contributory role in the pathogenesis and progression of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, MS, and ALS, as well as many other neurological conditions including hydrocephalus, idiopathic intracranial hypertension, migraines, seizures, silent-strokes, affective disorders, schizophrenia, and psychosis. The purpose of this paper is to provide an overview of the critical role of the CCJ in craniospinal hydrodynamics and to stimulate further research that may lead to new approaches for the prevention and treatment of the above neurodegenerative and neurological conditions.

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Normal pressure hydrocephalus in a case of schizophrenia

Cited by 5 publications

References 4 publications

Prevalence of Schizophrenia in Idiopathic Normal Pressure Hydrocephalus

Prevalence of Schizophrenia in Idiopathic Normal Pressure Hydrocephalus

Prevalence of possible idiopathic normal pressure hydrocephalus in older inpatients with schizophrenia: a replication study

The Role of the Craniocervical Junction in Craniospinal Hydrodynamics and Neurodegenerative Conditions

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