Normal Pubertal Development: Part II: Clinical Aspects of Puberty

Bordini, Brian; Rosenfield, Robert L.

doi:10.1542/pir.32-7-281

Cited by 70 publications

(53 citation statements)

References 37 publications

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“…Eine Stabilisierung dieses säkularen Trends zeichnete sich seit den 1950er Jahren ab. Auch in aktuellen Erhebungen liegt das Menarchealter weiterhin zwischen 12,5 und 13,0 Jahren [4].…”

Section: Pubertätsbeginn -Verlauf Und -Dauerunclassified

“…Bereits 6 Monate zuvor treten erste Schamhaare auf (Pubarche, [23]). Etwa 2 Jahre nach dem Beginn der Pubertät wird das Menarchealter erreicht, welches in Deutschland aktuell bei etwa 12,8 Jahren liegt [4]. Bei Jungen stellt das erste sichere klinische Zeichen der einsetzenden Pubertät die Größenzunahme des Hodens auf mehr als 3 ml mit im Mittel 11,8 Jahren dar.…”

Section: Pubertätsbeginn -Verlauf Und -Dauerunclassified

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Vorzeitiger, verspäteter und ausbleibender Pubertätsbeginn

Land

2012

Monatsschr Kinderheilkd

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“…Eine Stabilisierung dieses säkularen Trends zeichnete sich seit den 1950er Jahren ab. Auch in aktuellen Erhebungen liegt das Menarchealter weiterhin zwischen 12,5 und 13,0 Jahren [4].…”

Section: Pubertätsbeginn -Verlauf Und -Dauerunclassified

Vorzeitiger, verspäteter und ausbleibender Pubertätsbeginn

Land

2012

Monatsschr Kinderheilkd

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“…4,6 Using Tanner staging criteria, adrenarche is classified as stage 2 in pubic hair development, and thelarche is classified as stage 2 in breast development. 8 US population-based data demonstrate that the mean age of stage 2 breast development (B2) is 9.8 years and stage 2 pubic hair development (PH2) is 10.2 years, and that B2 occurs, on average, 5 months prior to PH2. 9 In a large longitudinal study, the median age of onset of B2 was 9.7 years for white non-Hispanic girls.…”

Section: Introductionmentioning

confidence: 99%

“…8,15 Menarche is premature before 11.2 years. 15 Breast development is defined as delayed after 13.3 years, 15 and menarche is delayed after age 16 or if it does not occur within 5 years of the initiation of puberty.…”

Section: Introductionmentioning

confidence: 99%

Pubertal Development in Rett Syndrome Deviates From Typical Females

Killian

Lane

Cutter

et al. 2014

Pediatric Neurology

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Background Rett syndrome is a unique neurodevelopmental disorder, affecting approximately 1 in 10,000 live female births, most experiencing reduced growth. We characterized pubertal trajectories in females with Rett syndrome. We hypothesized that pubertal trajectory deviates from the general female population with early pubertal onset and delayed menarche. Methods Participants were individuals enrolled in the Rett Syndrome Natural History Study with clinical diagnosis of Rett syndrome or mutations in MECP2. Intervals to thelarche, adrenarche, and menarche were assessed by survival analysis; BMI, mutation type, clinical severity, and pubertal milestone relationships were assessed by log-likelihood test; pathway synchrony (relationship between thelarche, adrenarche, and menarche) was assessed by Chi-squared analysis. Results Compared to the general female population, over 25% initiated puberty early, yet entered menarche later (median age 13.0 years). 19% experienced delayed menarche. Median length of puberty, from thelarche to menarche, was 3.9 years. Higher BMI correlated with earlier thelarche and adrenarche but not menarche; milder mutations correlated with earlier menarche; and milder clinical presentation correlated with earlier thelarche and menarche. Fifty-two percent entered puberty in synchrony, but differing from general population, 15% led with thelarche, and 32% with adrenarche. Conclusions Pubertal trajectories in Rett syndrome differ from general population, entering puberty early and reaching menarche later. BMI affects pubertal timing, but the relationship between specific mutations, clinical presentation, and underlying neuroendocrine pathology is less clear.

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“…Acne, oily skin, deepened voice, and adult-type body odor are also adrenal androgen-mediated effects. Linear growth starts to accelerate at genital and pubic hair stage 2 in males (Tanner 1985) and reaches a peak growth velocity of w9.5 cm/year during later stages of puberty (stages 3-4) and a testicular volume of 10-12 cc (Bordini & Rosenfield 2011). As skeletal growth and maturation occur, lean body mass as well as relative proportions of water, muscle, and bone also increase (Rogol 2010).…”

Section: Male Pubertal Developmentmentioning

confidence: 99%

Male pubertal development: are endocrine-disrupting compounds shifting the norms?

Zawatski¹,

Lee²

2013

Journal of Endocrinology

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Endocrine-disrupting compounds (EDCs) are synthetic or natural compounds that interfere with endogenous endocrine action. The frequent use of chemicals with endocrine active properties in household products and contamination of soil, water, and food sources by persistent chemical pollutants result in ubiquitous exposures. Wildlife observations and animal toxicological studies reveal adverse effects of EDCs on reproductive health. In humans, a growing number of epidemiological studies report an association with altered pubertal timing and progression. While these data are primarily reported in females, this review will focus on the small number of studies performed in males that report an association of polychlorinated biphenyls with earlier sexual maturity rating and confirm subtle effects of lead, dioxins, and endosulfan on delaying pubertal onset and progression in boys. Recent studies have also demonstrated that EDC exposure may affect pubertal testosterone production without having a noticeable effect on sexual maturity rating. A limitation to understand the effects of EDCs in humans is the potential for confounding due to the long temporal lag from early-life exposures to adult outcomes. The complex interplay of multiple environmental exposures over time also complicates the interpretation of human studies. These studies have identified critical windows of vulnerability during development when exposures to EDCs alter critical pathways and affect postnatal reproductive health. Contemporaneous exposures can also disrupt the hypothalamic-pituitary-gonadal axis. This paper will review the normal process of puberty in males and summarize human data that suggest potential perturbations in pubertal onset and tempo with early-life exposures to EDCs.

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Normal Pubertal Development: Part II: Clinical Aspects of Puberty

Cited by 70 publications

References 37 publications

Vorzeitiger, verspäteter und ausbleibender Pubertätsbeginn

Vorzeitiger, verspäteter und ausbleibender Pubertätsbeginn

Pubertal Development in Rett Syndrome Deviates From Typical Females

Male pubertal development: are endocrine-disrupting compounds shifting the norms?

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