Normal reference intervals of prognostic nutritional index in healthy adults: A large multi‐center observational study from Western China

Yang, Guishu; Wang, Dongsheng; He, Linbo; Zhang, Guangjie; Yu, Jianhong; Chen, Yaping; Yin, Hailin; Tian, Li; Lin, Ying; Luo, Huaichao

doi:10.1002/jcla.23830

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…It was calculated as serum albumin (g/L) + 5× absolute lymphocyte counts (×10 9 /L) as modified by Onodera et al [ 22 ]. Based on our previous finding and the normal reference intervals of PNI in China, [ 23 ] a PNI of ≥43.0 is considered normal, and a PNI of 38.0–42.9 and <38.0 reflect moderate and severe malnutrition, respectively. Similar to the GLIM criteria, there is no mild malnutrition for PNI.…”

Section: Methodsmentioning

confidence: 99%

Prevalence and Prognostic Significance of Malnutrition in Patients with Abnormal Glycemic Status and Coronary Artery Disease: A Multicenter Cohort Study in China

Wang²,

Liu

et al. 2023

Nutrients

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This study sought to investigate the prevalence and prognostic significance of malnutrition in patients with an abnormal glycemic status and coronary artery disease (CAD). This secondary analysis of a multicenter prospective cohort included 5710 CAD patients with prediabetes and 9328 with diabetes. Four objective tools were applied to assess the nutritional status of the study population. The primary endpoint was all-cause death. The association of malnutrition with clinical outcomes was examined using Cox proportional hazards regression. The proportion of malnutrition varied from 8% to 57% across the assessment tools. Diabetic patients were more likely to be malnourished than prediabetic patients. During a median follow-up of 2.1 years, 456 all-cause deaths occurred. The adjusted hazard ratios and 95% confidence interval for all-cause deaths of moderate–severe malnutrition defined by different tools ranged from 1.59 (1.03, 2.46) to 2.08 (0.92, 4.73) in prediabetic patients and 1.51 (1.00, 2.34) to 2.41 (1.78, 3.27) in diabetic patients. In conclusion, malnutrition is not rare in CAD patients with abnormal glycemic status. Moderate–severe malnutrition strongly predicted all-cause death regardless of the assessment tool. Assessing the nutritional status for all CAD patients with prediabetes and diabetes to identify individuals at high risk of all-cause death may help the risk assessment and prognosis improvement.

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Section: Methodsmentioning

confidence: 99%

Prevalence and Prognostic Significance of Malnutrition in Patients with Abnormal Glycemic Status and Coronary Artery Disease: A Multicenter Cohort Study in China

Wang²,

Liu

et al. 2023

Nutrients

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“…In addition, we calculated the PNI and NLR, which are parameters of nutritional status or prognostic factors identified in previous studies. [21][22][23][24] Although there is no defined reference range, [25][26][27] patients with deviating TSH (IFCC) levels tended to exhibit a decreased PNI and an increased NLR. These results suggested the possibility of a poor nutritional status and general condition in patients with deviating TSH (IFCC) levels.…”

Section: Clinical Characteristics Of Patients With Deviating Tsh (Ifc...mentioning

confidence: 99%

Instability of harmonized thyroid‐stimulating hormone immunoassays in clinical practice

Uto

Bando

Fukuoka

et al. 2023

Clinical Endocrinology

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Objective: Thyroid-stimulating hormone (TSH) harmonization is effective in minimizing differences between the results of immunoassays in healthy subjects.However, the effectiveness of TSH harmonization in clinical practice has not been investigated. The aim of this study was to evaluate the instability of TSH harmonization in clinical practice. Methods:We compared the reactivities of four harmonized TSH immunoassays using combined difference plots of 431 patients. We selected patients with statistically significant deviations in TSH levels and analyzed their thyroid hormone levels and clinical characteristics. Results:The combined difference plots showed that one harmonized TSH immunoassay exhibited markedly different reactivity even after TSH harmonization compared with the other three immunoassays. Among 109 patients with mild-tomoderate elevation of TSH levels, we selected 15 patients with statistically significant deviations in TSH levels according to the difference plots of three harmonized TSH immunoassays, excluding one immunoassay that showed different reactivity. The thyroid hormone levels of three patients were misclassified as hypothyroidism or normal due to deviating TSH levels. In terms of clinical characteristics, these patients were in poor nutritional status and general condition, possibly due to their severe illness (e.g., advanced metastatic cancer). Conclusion:We have confirmed that TSH harmonization in clinical practice is relatively stable. However, some patients showed deviating TSH levels in the harmonized TSH immunoassays, indicating the need for caution, particularly in poorly nourished patients. This finding suggests the presence of factors that contribute to the instability of TSH harmonization in such cases. Further investigation is warranted to validate these results.

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“…The PNI was calculated using the following formula: serum albumin g/L + 5 * lymphocyte count 10 9 /L [21,22]. A score of ≥43.0 is regarded as normal; scores of 38.0 to 42.9 and <38.0 reflect moderate and severe malnutrition, respectively [23]. There is no mild classification of the PNI.…”

Section: Eye Examinations and Retinopathymentioning

confidence: 99%

Malnutrition Is Associated with Diabetic Retinopathy in Patients with Type 2 Diabetes

Wei,

Lin,

et al. 2023

Journal of Diabetes Research

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Background. The relationship between malnutrition and diabetic retinopathy (DR) is still unclear. The purpose of this study is to investigate the relationship between malnutrition and DR in type 2 diabetic patients. Methods. A cross-sectional study was conducted on 612 patients with type 2 diabetes mellitus. Four malnutrition assessment tools: Global Leadership Initiative on Malnutrition (GLIM) criteria, controlling nutritional status (CONUT), nutritional risk index (NRI), and prognostic nutritional index (PNI), were applied to assess the nutritional status of the study population. The association between malnutrition and DR was examined using multivariable logistic regression and ordered logistic regression. Results. The proportion of malnutrition varied from 10.0% to 34.3% in total patients and from 16.3% to 45.1% in DR patients across the assessment tools. DR patients were more likely to be malnourished than patients without DR. The adjusted odds ratios (aOR) and 95% confidence interval (CI) for DR of malnutrition defined by different tools were 1.86 (1.01-3.14) for GLIM criteria, 1.67 (1.04-2.70) for NRI, and 2.24 (1.07-4.69) for PNI. The aOR and 95% CI for the severity of DR of malnutrition defined by different tools were 1.99 (1.12-3.51) for GLIM criteria, 1.65 (1.06-2.58) for NRI, and 2.51 (1.31-4.79) for PNI. Conclusions. Malnutrition was common in DR patients, and it was closely linked to the presence and severity of DR. Diabetic patients with DR should undergo nutritional assessment and early treatment of malnutrition to prevent the onset or progression of DR.

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Normal reference intervals of prognostic nutritional index in healthy adults: A large multi‐center observational study from Western China

Cited by 5 publications

References 23 publications

Prevalence and Prognostic Significance of Malnutrition in Patients with Abnormal Glycemic Status and Coronary Artery Disease: A Multicenter Cohort Study in China

Prevalence and Prognostic Significance of Malnutrition in Patients with Abnormal Glycemic Status and Coronary Artery Disease: A Multicenter Cohort Study in China

Instability of harmonized thyroid‐stimulating hormone immunoassays in clinical practice

Malnutrition Is Associated with Diabetic Retinopathy in Patients with Type 2 Diabetes

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