Normal right- and left ventricular volumes and myocardial mass in children measured by steady state free precession cardiovascular magnetic resonance

Buechel, Emanuela R. Valsangiacomo; Kaiser, Thomas; Jackson, Clare; Schmitz, A.; Kellenberger, Christian J.

doi:10.1186/1532-429x-11-19

Cited by 181 publications

(195 citation statements)

References 27 publications

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“…LVRI values were determined for normal volunteers (1.03 ± 0.12) and those with dilated (LVRI = 0.55 ± 009) and hypertrophic (LVRI = 2.4 ± 067) cardiomyopathies. In normal pediatric populations, LVRI determined by TTE (aka MVR) has been reported to be lower (0.91 [20] and 0.68 [23]) than for adults. The fact that CMR was used for the current study augments our conclusion that no differences in LVRI exist between subjects with DMD-associated heart disease and normal controls, as CMR is generally accepted as more sensitive than TTE in measurements of EDV and LVM.…”

Section: Discussionmentioning

confidence: 99%

Patterns of left ventricular remodeling in patients with Duchenne Muscular Dystrophy: a cardiac MRI study of ventricular geometry, global function, and strain

Mazur

Hor

Germann

et al. 2011

Int J Cardiovasc Imaging

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The cardiac disease ubiquitously associated in Duchenne Muscular Dystrophy (DMD) has traditionally been considered a progressive dilated cardiomyopathy (DCM). However, left ventricular (LV) dilatation as measured with cardiac MRI has not been a consistent finding in this population, even as circumferential strain (ε(cc)) declines with advancing disease. We hypothesized that a distinct pattern of changes in LV geometry, during the course of ε(cc) decline, distinguishes DMD associated heart disease from DCM. Using CMR, LV end-diastolic volume (EDV), mass (LVM), ejection fraction, ε(cc) and myocardial delayed enhancement (MDE) were determined in DMD patients and normal control subjects. The LV Remodeling Index (LVRI) was calculated as the ratio of LV Mass to Volume (LVM/EDV). Statistical comparisons between all LV parameters and genotype were also performed. Median LVRI in DMD (n = 127) and control subjects (n = 41) were different (0.75 vs. 0.65, P = 0.0150) but within normal range. Furthermore, the median LVRI in DMD boys with reduced LV systolic function was significantly reduced compared to those with normal LV systolic function (0.64 vs. 0.75, P = 0.0974). However, the presence of MDE was associated with a lower median LVRI (0.57 vs. 0.76, P = 0.0471). Regression analysis showed no significant correlation between ε(cc) and LVRI (r = -0.03). The LVRI of DMD patients is unexpectedly normal and not correlated with ε(cc.) Based on these findings, DMD-associated heart disease exhibits a unique remodeling pattern distinct from DCM.

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Section: Discussionmentioning

confidence: 99%

Patterns of left ventricular remodeling in patients with Duchenne Muscular Dystrophy: a cardiac MRI study of ventricular geometry, global function, and strain

Mazur

Hor

Germann

et al. 2011

Int J Cardiovasc Imaging

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“…It is likely that an RV end-diastolic volume in a particular patient (eg, 150 -180 mL/m 2 body surface area), as often is used to support a clinical decision over pulmonary valve replacement, should actually be interpreted differently for male and female patients. 4,23,24 Ignoring gender may result in female patients experiencing relatively more-severe ven- AT indicates anaerobic threshold; BP, blood pressure; CMR, cardiac magnetic resonance; LV, left ventricle; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricular ejection fraction; LVESV, left ventricular end-systolic volume; NYHA, New York Heart Association; PC, phase contrast; PVR, pulmonary valve replacement, RV, right ventricle; RVEDV, right ventricular end-diastolic volume; RVEF, right ventricular ejection fraction; RVESV, right ventricular end-systolic volume; RVOT, right ventricular outflow tract; PAP, pulmonary artery plasty; TAP, transannular patch. *Significant at PϽ0.05.…”

Section: Clinical Impact Of the Study Findingsmentioning

confidence: 99%

Impact of Gender and Age on Cardiovascular Function Late After Repair of Tetralogy of Fallot

Sarikouch

Koerperich

Dubowy

et al. 2011

Circ: Cardiovascular Imaging

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Background-The impact of gender and age on cardiac function by cardiac magnetic resonance (CMR) in repaired tetralogy of Fallot (TOF) is unknown, which limits the value of currently discussed volumetric thresholds and the accuracy of individual follow-up. Methods and Results-In a nationwide, prospective, 14-center study, 407 consecutive patients with repaired TOF (age, 17.9Ϯ8.3 years; range, 8 -59 years; 226 male patients) underwent standardized CMR ventricular volumetry and flow quantification (pulmonary artery/ascending aorta). There were no sex differences for age at TOF repair, type of repair, number of prior repair palliations or reinterventions after repair, pulmonary regurgitation fraction, and maximal gradient across the right ventricular outflow tract. Biventricular volumes and mass (indexed to body surface area), available in 380 of 407 patients, respectively, were higher in male patients (PϽ0.003), but biventricular ejection fraction was higher in female patients (PϽ0.012). As opposed to reported data of healthy populations, sex-specific reference percentiles computed for an age range of 8 to 40 years (lambda-mu-sigma method) demonstrated (1) an increase of end-diastolic and end-systolic left ventricular volumes, particularly in female patients; (2) an increase of end-systolic right ventricular volumes in both sexes; and (3) a decrease of biventricular ejection fraction in male patients, whereas in female patients, only right ventricular ejection fraction decreased. Conclusions-Significant gender differences of biventricular volumes, function, and mass by CMR exist late after repair of TOF, suggesting that age and gender cannot be ignored when discussing thresholds. Gender-specific percentiles may present a more relevant framework of reference for an individual patient at a given age and suggest a gradual decline of biventricular systolic function over time.

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“…Les normogrammes établis chez l'enfant, indexés sur l'âge ou sur la surface corporelle [6], montrent un net accroissement des valeurs normales à mesure que l'on se rapproche de l'âge adulte. Par exemple, la limite supérieure de la normale de l'index de volume télédiastolique du VD (IVTD) est de l'ordre de 70 mL/m 2 chez le nourrisson de 1 an et passe à 120 mL/m 2 vers 18 ans.…”

Section: Valeurs Normales Des Volumes Du Ventricule Droitunclassified

Évaluation de la fonction du ventricule droit par l’imagerie en coupes

Germain¹,

El-Ghannudi-Abdo²,

Jeung³

2013

Imagerie en Coupes Du Cœur Et Des Vaisseaux

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Les diffi cultés d'analyse du ventricule droit (VD) par échocardiographie sont bien connues. Dans ce domaine, l'avantage de l'imagerie en coupe réside dans l'absence de toute modélisation géométrique pour quantifi er les volumes et la fonction systolique du VD. En outre, l'IRM off re une quantifi cation des fl ux très utile pour estimer les fuites pulmonaires ou tricuspides et pour quantifi er le rapport des débits Qp/Qs. Les applications cliniques essentielles concernent : l'HTAP, l'infarctus du VD, la dysplasie du VD et surtout les cardiopathies congénitales de l'adulte altérant le VD. Le scanner cardiaque off re une résolu-tion spatiale supérieure à l'IRM, mais sa place pratique reste limitée dans les pathologies du VD car l'approche fonctionnelle est inférieure à celle de l'IRM et en raison de la nécessité d'injection d'un produit de contraste iodé ainsi que de son caractère irradiant.

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Normal right- and left ventricular volumes and myocardial mass in children measured by steady state free precession cardiovascular magnetic resonance

Abstract: Background: Quantification of ventricular volume by Steady State Free Precession (SSFP) cardiovascular magnetic resonance is accurate and reproducible. Normal values exist for adults, but are lacking for children.

Cited by 181 publications

References 27 publications

Patterns of left ventricular remodeling in patients with Duchenne Muscular Dystrophy: a cardiac MRI study of ventricular geometry, global function, and strain

Patterns of left ventricular remodeling in patients with Duchenne Muscular Dystrophy: a cardiac MRI study of ventricular geometry, global function, and strain

Impact of Gender and Age on Cardiovascular Function Late After Repair of Tetralogy of Fallot

Évaluation de la fonction du ventricule droit par l’imagerie en coupes

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