Normal values of 24-h ambulatory intraluminal impedance combined with pH-metry in subjects eating a Mediterranean diet

Zentilin, Patrizia; Iiritano, E.; Dulbecco, Pietro; Bilardi, C.; Savarino, Edoardo; Conca, S. De; Parodi, A. Ferretto; Reglioni, S.; Vigneri, Simone; Savarino, Vincenzo

doi:10.1016/j.dld.2005.12.011

Cited by 143 publications

(144 citation statements)

References 25 publications

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“…The upper limit of 24-hour esophageal acid exposure in our volunteers was 3.7%, which corresponds to the normal values obtained by traditional 24-hour pH monitoring. 20 The corresponding values reported by Shay et al, 11 Zerbib et al, 12 Zentilin et al, 13 and Xiao et al, 14 were 1.2%, 0.9%, 0.5%, and 0.4%, respectively. This suggests that the acid exposure time may be shorter in eastern than western populations.…”

Section: Discussionmentioning

confidence: 55%

“…If the criteria of other studies are adopted, apparent gas reflux events with a belch event marker often cannot be categorized as gas reflux. Also, the sensitivity of automated analysis with BioView software for detection of gas reflux is rather low and it is possible that investigators in previous studies [11][12][13][14] missed a number of gas reflux events. Gas reflux events are thought to play an important role in several situations.…”

Section: Discussionmentioning

confidence: 99%

“…Balaji et al 10 reported that 26.7% of all events were gas reflux events and 65% of all events were non-acidic reflux (using the same definition of nonacidic reflux as ours). In addition, Zentilin et al 13 found that gas reflux events accounted for 29% of all reflux events. In our study, about 40% of events were gas reflux, and larger percentage of the gas reflux events in our study is more similar to these two reports than other reports.…”

Section: Discussionmentioning

confidence: 99%

“…There have already been some reports of normal values determined in healthy volunteers of other countries. [10][11][12][13][14] In a normative study from the USA, 11 only liquid-containing (liquid and mixed) reflux was analyzed. In another normative study from Europe, 12 gas reflux events were considered separately and were not characterized by pH.…”

Section: Introductionmentioning

confidence: 99%

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Liquid-containing Refluxes and Acid Refluxes May Be Less Frequent in the Japanese Population Than in Other Populations: Normal Values of 24- hour Esophageal Impedance and pH Monitoring

Kawamura

Kohata

Kawami

et al. 2016

J Neurogastroenterol Motil

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6Kurokawa general hospital, Miyagi, Japan Background/AimsTwenty-four-hour esophageal impedance and pH monitoring allows detection of all types of reflux episodes and is considered the best technique for identifying gastroesophageal refluxes. However, normative data for the Japanese population are lacking. This multicenter study aimed to establish the normal range of 24-hour esophageal impedance and pH data both in the distal and the proximal esophagus in Japanese subjects. MethodsForty-two healthy volunteers (25 men and 17 women) with a mean ± standard deviation age of 33.3 ± 12.4 years (range: 22-72 years) underwent a combined 24-hour esophageal impedance and pH monitoring. According to the physical and pH properties, distal or proximal esophageal reflux events were categorized. ResultsMedian 45 reflux events occurred in 24 hours, and the 95th percentile was 85 events. Unlike previous reports, liquid-containing reflux events are median 25/24 hours with the 95th percentile of 62/24 hours. Acidic reflux events were median 11/24 hours with the 95th percentile of 39/24 hours. Non-acidic gas reflux events were median 15/24 hours with the 95th percentile of 39/24 hours. Proximal reflux events accounted for 80% of the total reflux events and were mainly non-acidic gas refluxes. About 19% of liquid and mixed refluxes reached the proximal esophagus. ConclusionsUnlike previous studies, liquid-containing and acidic reflux events may be less frequent in the Japanese population. Non-acidic gas reflux events may be frequent and a cause of frequent proximal reflux events. This study provides important normative data for 24-hour impedance and pH monitoring in both the distal and the proximal esophagus in the Japanese population.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Liquid-containing Refluxes and Acid Refluxes May Be Less Frequent in the Japanese Population Than in Other Populations: Normal Values of 24- hour Esophageal Impedance and pH Monitoring

Kawamura

Kohata

Kawami

et al. 2016

J Neurogastroenterol Motil

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“…[14][15][16] Patients were classified as combined esophageal acid refluxers if the % time esophageal pH less than 4 during upright and supine postures were more than 6.3 and 1.2, respectively, during the 24-hour period.…”

Section: -Hour Ph and Impedance Analysismentioning

confidence: 99%

Esophageal Acidification During Nocturnal Acid-breakthrough with Ilaprazole Versus Omeprazole in Gastroesophageal Reflux Disease

Karyampudi

Ghoshal

Singh

et al. 2017

J Neurogastroenterol Motil

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Background/AimsThough nocturnal acid-breakthrough (NAB) is common in gastroesophageal reflux disease (GERD) patients, its clinical importance results from esophageal acidification, which has been shown to be uncommon. Ilaprazole, a long-acting proton pump inhibitor, may cause NAB infrequently. Accordingly, we studied prospectively, (1) frequency and degree of esophageal acidification during NAB, and (2) frequency and severity of NAB while on ilaprazole versus omeprazole. MethodsFifty-eight consecutive patients with GERD on once daily ilaprazole, 10 mg (n = 28) or omeprazole, 20 mg (n = 30) for > one month underwent 24-hour impedance-pH monitoring prospectively. NAB was defined as intra-gastric pH < 4 for > one hour during night, and esophageal acidification as pH < 4 for any duration. Nocturnal symptoms (heartburn, regurgitation, and chest pain) were also recorded. Results Of ConclusionsThough NAB was common while patients were on a proton pump inhibitor, esophageal acidification was uncommon. Frequency and severity of NAB were comparable among patients on ilaprazole and omeprazole, except for the lesser number of NABs with ilaprazole.

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GER in Cystic Fibrosis

Woodley

Bass

Hayes

et al. 2022

Gastroesophageal Reflux in Children

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Normal values of 24-h ambulatory intraluminal impedance combined with pH-metry in subjects eating a Mediterranean diet

Cited by 143 publications

References 25 publications

Liquid-containing Refluxes and Acid Refluxes May Be Less Frequent in the Japanese Population Than in Other Populations: Normal Values of 24- hour Esophageal Impedance and pH Monitoring

Liquid-containing Refluxes and Acid Refluxes May Be Less Frequent in the Japanese Population Than in Other Populations: Normal Values of 24- hour Esophageal Impedance and pH Monitoring

Esophageal Acidification During Nocturnal Acid-breakthrough with Ilaprazole Versus Omeprazole in Gastroesophageal Reflux Disease

GER in Cystic Fibrosis

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