Normal Values of Left Atrial Size and Function and the Impact of Age: Results of the World Alliance Societies of Echocardiography Study

Singh, Amita; Singulane, Cristiane Carvalho; Miyoshi, Tatsuya; Prado, Aldo; Addetia, Karima; Bellino, Michele; Daimon, Masao; Fajardo, Pedro Gutiérrez; Kasliwal, Ravi R; Kirkpatrick, James N.; Monaghan, Mark; Muraru, Denisa; Ogunyankin, Kofo O.; Park, Seung Woo; Ronderos, Ricardo; Sadeghpour, Anita; Scalia, G.; Takeuchi, Masaaki; Tsang, Wendy; Tucay, Edwin S.; Rodrigues, Ana Clara Tude; Amuthan, Vivekanandan; Zhang, Yun; Schreckenberg, Marcus; Blankenhagen, Michael; Degel, Markus; Hitschrich, Niklas; Mor‐Avi, Victor; Asch, Federico M.; Lang, Roberto M.; Investigators, Wase

doi:10.1016/j.echo.2021.08.008

Cited by 73 publications

(62 citation statements)

References 25 publications

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“…The authors found that LVEDV, LVEDVi, LVESV, and LVESVi all decreased with increasing age amongst men and women [17] . The progressive increase in LV chamber stiffness with age accounts for the decrease in LV volumes with aging [18] .…”

Section: Volumetric Measurementsmentioning

confidence: 99%

“…One of the key abnormalities in HFpEF is LV diastolic dysfunction, and the prevalence of LV diastolic dysfunction increases significantly with age [28][29][30][31] . Aging itself is associated with changes in LV myocardial relaxation and LV chamber stiffness [18] . Of all the physiologic factors that impact LV diastolic function, age has been shown to be the strongest determinant [32,33] .…”

Section: Diastolic Functionmentioning

confidence: 99%

“…Besides the morphologic assessment of the cardiac chambers' volumes and LV mass, the most important echocardiographic parameters for evaluation of LV diastolic function include pulse-Doppler flow profiles (transmitral and pulmonary venous flow), tissue Doppler imaging (TDI) mitral annular velocities, and pulmonary artery systolic pressure [Figures 1 and 2] [18] . Transmitral E/A ratio, and pulmonary vein peak systolic to peak diastolic velocity ratio are indices of early diastolic LV filling pressures that are most accurate in patients with LV systolic dysfunction and depressed LV EF [18] . Mitral annulus early diastolic velocity (e') is an index of LV relaxation, whereas E/e' ratio is an index of LV early diastolic pressures that can be applied in patients with normal as well as in patients with depressed LV EF [18] .…”

Section: Diastolic Functionmentioning

confidence: 99%

“…Transmitral E/A ratio, and pulmonary vein peak systolic to peak diastolic velocity ratio are indices of early diastolic LV filling pressures that are most accurate in patients with LV systolic dysfunction and depressed LV EF [18] . Mitral annulus early diastolic velocity (e') is an index of LV relaxation, whereas E/e' ratio is an index of LV early diastolic pressures that can be applied in patients with normal as well as in patients with depressed LV EF [18] . Here, we discuss some of the notable studies that illustrated age-related changes in these parameters.…”

Section: Diastolic Functionmentioning

confidence: 99%

“…However, importantly, the difference in duration between mitral inflow A velocity and pulmonary venous A R velocity (time interval: A R -A) does not change significantly with age. This is important as A R -A duration is an index of LV end-diastolic pressure [18] .…”

Section: Diastolic Functionmentioning

confidence: 99%

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Changes in cardiac structure and function with aging

Agrawal¹,

Nagueh²

2022

JCA

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Aging is associated with progressive changes in cardiac structure and function. The prevalence of cardiovascular risk factors and disease also increases profoundly with advancing age. Therefore, understanding the spectrum of physiological changes in the aging heart is crucial for the identification and risk stratification of cardiovascular disease. In this review, we discuss echocardiographic features of age-related cardiac remodeling.

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Section: Volumetric Measurementsmentioning

confidence: 99%

Section: Diastolic Functionmentioning

confidence: 99%

Section: Diastolic Functionmentioning

confidence: 99%

Section: Diastolic Functionmentioning

confidence: 99%

Section: Diastolic Functionmentioning

confidence: 99%

See 3 more Smart Citations

Changes in cardiac structure and function with aging

Agrawal¹,

Nagueh²

2022

JCA

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Diagnostic value of reduced left atrial compliance during ergometry exercise in heart failure with preserved ejection fraction

Harada

Kagami

Shina

et al. 2023

European J of Heart Fail

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AimsDiagnosis of heart failure with preserved ejection fraction (HFpEF) remains challenging in patients presenting with chronic dyspnoea. We sought to determine the diagnostic value of reduced left atrial (LA) compliance during exercise to diagnose HFpEF.Methods and resultsErgometry exercise stress echocardiography was performed in 225 patients with HFpEF and 262 non‐heart failure controls (non‐cardiac dyspnoea [NCD]) in Protocol 1, where the diagnosis of HFpEF was defined by the HFA‐PEFF algorithm. In Protocol 2, the diagnosis of HFpEF was ascertained by exercise right heart catheterization in 67 participants (49 HFpEF and 18 NCD). Speckle‐tracking echocardiography was performed at rest and during exercise to determine LA compliance (ratio of LA reservoir strain to E/e'). As compared with NCD, patients with HFpEF demonstrated decreased LA reservoir strain and compliance at rest, and these differences further increased during exercise in Protocol 1. Exercise LA compliance discriminated HFpEF from NCD (area under the curve 0.87, p < 0.0001), with a superior diagnostic ability to exercise E/e' ratio (DeLong p = 0.005). Exercise LA compliance demonstrated incremental diagnostic value over clinical factors (age, systemic hypertension, and atrial fibrillation) and resting LA compliance (χ2 212.4 vs. 166.2, p < 0.0001). These findings were confirmed in Protocol 2.ConclusionLeft atrial compliance during exercise demonstrated superior diagnostic ability to exercise E/e' ratio, with incremental diagnostic value over the resting LA compliance. Exercise LA compliance may enhance the diagnosis of HFpEF among patients with dyspnoea.

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Left atrial functional changes as emerging diagnostic and prognostic marker

Floria

Burlacu

2022

J of Clinical Ultrasound

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Normal Values of Left Atrial Size and Function and the Impact of Age: Results of the World Alliance Societies of Echocardiography Study

Cited by 73 publications

References 25 publications

Changes in cardiac structure and function with aging

Changes in cardiac structure and function with aging

Diagnostic value of reduced left atrial compliance during ergometry exercise in heart failure with preserved ejection fraction

Left atrial functional changes as emerging diagnostic and prognostic marker

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