Normal Values of Magnetic Relaxation Parameters of Spine Components with the Synthetic MRI Sequence

Drake-Pérez, Marta; Delattre, Bénédicte; Boto, José; Fitsiori, Aikaterini; Lövblad, Karl-Olof; Boudabbous, Sana; Vargas, Maria Isabel

doi:10.3174/ajnr.a5566

Cited by 25 publications

(15 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on the T 2 measurement, a tube of 2.5 mmol/L gadolinium water (T 2 relaxation time = 62 msec) was selected to roughly match the disc tissue T 2 relaxation times (50–100 msec) to increase the curve‐fitting accuracy (Fig. b) . Samples were placed in a custom‐built compression device made of nonmagnetic materials to maintain hydration conditions during imaging (Fig.…”

Section: Methodsmentioning

confidence: 99%

Direct Quantification of Intervertebral Disc Water Content Using MRI

Yang

Wendland

O’Connell

2020

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Background Water content is a key parameter for simulating tissue swelling and nutrient diffusion. Accurately measuring water content throughout the intervertebral disc (NP = nucleus pulposus; AF = annulus fibrosus) is important for developing patient‐specific models. Water content is measured using destructive techniques, Quantitative MRI has been used to estimate water content and detect early degeneration, but it is dependent on scan parameters, concentration of free water molecules, and fiber architecture. Purpose To directly measure disc‐tissue water content using quantitative MRI and compare MRI‐based measurements with biochemical assays, and to quantify changes in disc geometry due to compression. Study Type Basic science, controlled. Specimen Twenty bone‐disc‐bone motion segments from skeletally mature bovines. Field Strength/Sequence 7T/3D fast low angle shot (FLASH) pulse sequence and a T2 rapid imaging with refocused echoes (RARE) sequence. Assessment Disc volumes, NP and AF volumetric water content, and T2 relaxation times were measured through MRI; NP and AF tissue gravimetric water content, mass density, and glycosaminoglycan content were measured through a biochemical assay. Statistical Tests Correlations between MRI‐based measurement and biochemical composition were evaluated using Pearson's linear regression. Results Mechanical dehydration resulted in a decrease in disc volume by up to 20% and a decrease in disc height by up to 35%. Direct water content measurements for the NP was achieved by normalizing MRI‐based spin density by NP mass density (1.10 ± 0.03 g/cm3). However, the same approach underestimated water content in the AF by ~10%, which may be due to a higher concentration of collagen fibers and bound water molecules. Data Conclusion Spin density or spin density normalized by mass density to estimate NP and AF water content was more accurate than correlations between water content and relaxation times. Mechanical dehydration decreased disc volume and disc height, and increased maximum cross‐sectional area. Level of Evidence Technical Efficacy Stage J. Magn. Reson. Imaging 2020;52:1152–1162.

show abstract

Section: Methodsmentioning

confidence: 99%

Direct Quantification of Intervertebral Disc Water Content Using MRI

Yang

Wendland

O’Connell

2020

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…Although the diagnostic accuracy with conventional T2WI was slightly higher than that with synthetic T2WI, the difference was not statistically significant. It may be due to the fact that the signal intensity of synthetic T2WI was generally lower than that of conventional T2WI [ 14 , 31 ], and observers are more accustomed to the contrast and signal intensity of conventional T2WI. Therefore, we proposed that, with training and adaptation, synthetic T2WI might be as suitable for T stage and EMVI assessment of RC as conventional T2WI.…”

Section: Discussionmentioning

confidence: 99%

A preliminary study of synthetic magnetic resonance imaging in rectal cancer: imaging quality and preoperative assessment

Liang

Wu³

et al. 2021

Insights Imaging

View full text Add to dashboard Cite

Purpose To compare the imaging quality, T stage and extramural venous invasion (EMVI) evaluation between the conventional and synthetic T2-weighted imaging (T2WI), and to investigate the role of quantitative values obtained from synthetic magnetic resonance imaging (MRI) for assessing nodal staging in rectal cancer (RC). Methods Ninety-four patients with pathologically proven RC who underwent rectal MRI examinations including synthetic MRI were retrospectively recruited. The image quality of conventional and synthetic T2WI was compared regarding signal-to-noise ratio (SNR), contrast-to-noise (CNR), sharpness of the lesion edge, lesion conspicuity, absence of motion artifacts, and overall image quality. The accuracy of T stage and EMVI evaluation on conventional and synthetic T2WI were compared using the Mc-Nemar test. The quantitative T1, T2, and PD values were used to predict the nodal staging of MRI-evaluated node-negative RC. Results There were no statistically significant differences between conventional and synthetic T2WI in SNR, CNR, overall image quality, lesion conspicuity, and absence of motion artifacts (p = 0.058–0.978). There were no significant differences in the diagnostic accuracy of T stage and EMVI between conventional and synthetic T2WI from two observers (p = 0.375 and 0.625 for T stage; p = 0.625 and 0.219 for EMVI). The T2 value showed good diagnostic performance for predicting the nodal staging of RC with the area under the receiver operating characteristic, sensitivity, specificity, and accuracy of 0.854, 90.0%, 71.4%, and 80.3%, respectively. Conclusions Synthetic MRI may facilitate preoperative staging and EMVI evaluation of RC by providing synthetic T2WI and quantitative maps in one acquisition.

show abstract

“…The main advantage is that synthetic MRI can generate quantitative maps as well as morphologic MR images, whereas conventional MRI only provides morphologic MR images (11,18–23). Quantitative image information can offer radiologists new tools for both diagnosis and monitoring of disease progression (32). Tissue relaxation time has been used in studies to assess degeneration of the spine, for example, pathological osteoporosis and disc degeneration (4,33–35), but could also be applied to spinal tumor, such as differentiating benign from malignant tumor, estimating the extent of malignant spine tumor, differentiating radiation changes from tumor progression and evaluating therapeutic effects (5,35,36).…”

Section: Discussionmentioning

confidence: 99%

Synthetic MRI of the lumbar spine at 3.0 T: feasibility and image quality comparison with conventional MRI

Zhang

Zhu

et al. 2019

Acta Radiol

View full text Add to dashboard Cite

Background Synthetic magnetic resonance imaging (MRI), which can generate multiple morphologic MR images as well as quantitative maps from a single sequence, is not widely used in the spine at 3.0 T. Purpose To investigate the feasibility of synthetic MRI of the lumbar spine in clinical practice at 3.0 T. Material and Methods Eighty-four patients with lumbar diseases underwent conventional T1-weighted images, T2-weighted images, short-tau inversion recovery (STIR) images, and synthetic MRI of the lumbar spine at 3.0 T. The quantitative and qualitative image quality and agreement for detection of spinal lesions between conventional and synthetic MRI were compared by two radiologists. Results The signal-to-noise ratios of synthetic MRI showed an inferior image quality in the vertebrae and disc, whereas were higher for spinal canal and fat on the synthetic T1-weighted, T2-weighted, and STIR images. The contrast-to-noise ratios of the synthetic MRI was superior to conventional sequences, except for the vertebrae–disc contrast-to-noise ratio on T1-weighted imaging ( P = 0.005). Image quality assessments showed that synthetic MRI had greater STIR fat suppression ( P < 0.001) and fluid brightness ( P = 0.014), as well as higher degree of artifacts ( P < 0.001) and worse spatial resolution ( P = 0.002). The inter-method agreements for detection of spinal lesions were substantial to perfect (kappa, 0.614–0.925). Conclusion Synthetic MRI is a feasible method for lumbar spine imaging in a clinical setting at 3.0-T MR. It provides morphologic sequences with acceptable image quality, good agreement with conventional MRI for detection of spinal lesions and quantitative image maps with a slightly shorter acquisition time compared with conventional MRI.

show abstract

Normal Values of Magnetic Relaxation Parameters of Spine Components with the Synthetic MRI Sequence

Abstract: Measurements can be easily obtained on SyMRI and correlated with previously published values obtained using conventional relaxometry techniques.

Cited by 25 publications

References 40 publications

Direct Quantification of Intervertebral Disc Water Content Using MRI

Direct Quantification of Intervertebral Disc Water Content Using MRI

A preliminary study of synthetic magnetic resonance imaging in rectal cancer: imaging quality and preoperative assessment

Synthetic MRI of the lumbar spine at 3.0 T: feasibility and image quality comparison with conventional MRI

Contact Info

Product

Resources

About