Normal Variation of Bronchial Reactivity in Nonasthmatics is Associated with the Level of Mite-Specific IgE

Nogalo, Boro; Mirić, Mirjana; Maloča, Ivana; Turkalj, Mirjana; Plavec, Davor

doi:10.1080/02770900701847084

Cited by 8 publications

(13 citation statements)

References 23 publications

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“…In support of this, Nogalo et al. (17) recently showed in mite sensitive non‐asthmatic subjects a positive relationship between specific IgE to mite and AHR. We did not measure AHR in our children and cannot therefore confirm these associations directly.…”

Section: Discussionmentioning

confidence: 67%

Asthma, atopy and exhaled nitric oxide in a cohort of 6‐yr‐old New Zealand children

Crane

Lampshire

Wickens

et al. 2011

Pediatric Allergy Immunology

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Section: Discussionmentioning

confidence: 67%

Asthma, atopy and exhaled nitric oxide in a cohort of 6‐yr‐old New Zealand children

Crane

Lampshire

Wickens

et al. 2011

Pediatric Allergy Immunology

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“…Such association has been reported to show the association with not only the sensitization itself but also allergen types and each specific allergen 13, 17, 19–22. In other studies, the association of sensitization to house dust mite, cat allergen, timothy grass allergen, cockroach allergen, ragweed, and other specific allergen with AHR has been shown 12, 23–26. Sensitization to specific allergens is very important to develop asthma but there may be a great difference depending on regions particularly.…”

Section: Introductionmentioning

confidence: 88%

Airway hyperresponsiveness is associated with total serum immunoglobulin E and sensitization to aeroallergens in Korean adolescents

et al. 2010

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“…A previous study by Burrows and colleagues[13] investigated the associates of AHR in children, looking at the sizes of skin test wheals when analysing atopy, and demonstrated that the sizes of the reactions to mite, cat, dog and Aspergillus fumigatus were independently correlated with airway hyperresponsiveness, particularly when summed. Another study by Nogalo et al[12] looked specifically at the associations between airway hyperresponsiveness and level of specific mite specific IgE amongst mite-sensitised non-asthmatic children, and found that these were independently associated.…”

Section: Discussionmentioning

confidence: 99%

“…A study in the US has demonstrated that AHR increased significantly amongst adult asthmatics with increasing size of skin test wheals to inhalant allergens[11]. A significant association was also reported amongst non-asthmatic individuals with increasing level of mite specific IgE[12]. …”

Section: Introductionmentioning

confidence: 99%

Quantification of atopy, lung function and airway hypersensitivity in adults

Marinho

Simpson

Marsden

et al. 2011

Clinical & Translational All

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BackgroundStudies in children have shown that concentration of specific serum IgE (sIgE) and size of skin tests to inhalant allergens better predict wheezing and reduced lung function than the information on presence or absence of atopy. However, very few studies in adults have investigated the relationship of quantitative atopy with lung function and airway hyperresponsiveness (AHR).ObjectiveTo determine the association between lung function and AHR and quantitative atopy in a large sample of adults from the UK.MethodsFEV1 and FVC (% predicted) were measured using spirometry and airway responsiveness by methacholine challenge (5-breath dosimeter protocol) in 983 subjects (random sample of 800 parents of children enrolled in a population-based birth cohort enriched with 183 patients with physician-diagnosed asthma). Atopic status was assessed by skin prick tests (SPT) and measurement of sIgE (common inhalant allergens). We also measured indoor allergen exposure in subjects' homes.ResultsSpirometry was completed by 792 subjects and 626 underwent methacholine challenge, with 100 (16.0%) having AHR (dose-response slope>25). Using sIgE as a continuous variable in a multiple linear regression analysis, we found that increasing levels of sIgE to mite, cat and dog were significantly associated with lower FEV1 (mite p = 0.001, cat p = 0.0001, dog p = 2.95 × 10-8). Similar findings were observed when using the size of wheal on skin testing as a continuous variable, with significantly poorer lung function with increasing skin test size (mite p = 8.23 × 10-8, cat p = 3.93 × 10-10, dog p = 3.03 × 10-15, grass p = 2.95 × 10-9). The association between quantitative atopy with lung function and AHR remained unchanged when we repeated the analyses amongst subjects defined as sensitised using standard definitions (sIgE>0.35 kUa/l, SPT-3 mm>negative control).ConclusionsIn the studied population, lung function decreased and AHR increased with increasing sIgE levels or SPT wheal diameter to inhalant allergens, suggesting that atopy may not be a dichotomous outcome influencing lung function and AHR.

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Normal Variation of Bronchial Reactivity in Nonasthmatics is Associated with the Level of Mite-Specific IgE

Abstract: Even in subjects without allergic symptoms, IgE-mediated sensitization does not appear to be all or nothing phenomenon influencing the normal variability of underlying airway reactivity.

Cited by 8 publications

References 23 publications

Asthma, atopy and exhaled nitric oxide in a cohort of 6‐yr‐old New Zealand children

Asthma, atopy and exhaled nitric oxide in a cohort of 6‐yr‐old New Zealand children

Airway hyperresponsiveness is associated with total serum immunoglobulin E and sensitization to aeroallergens in Korean adolescents

Quantification of atopy, lung function and airway hypersensitivity in adults

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