Normalizing Eating Behavior Reduces Body Weight and Improves Gastrointestinal Hormonal Secretion in Obese Adolescents

Galhardo, Júlia; Hunt, Linda; Lightman, Stafford L.; Sabin, Matthew A.; Bergh, Cecilia; Södersten, P.; Shield, Julian

doi:10.1210/jc.2011-1999

Cited by 80 publications

(65 citation statements)

References 31 publications

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“…The Use of the Mandometer Bergh, Södersten and colleagues have developed a device which they call the Mandometer that provides patients with feedback on their rate of eating [48][49][50][51][52] . In several publications these investigators have reported that providing patients with such feedback can either accelerate or decelerate the rate of eating behavior, increasing the rate in those who eat too slowly, while decelerating it in those who eat too quickly.…”

Section: Other Biological Therapiesmentioning

confidence: 99%

Biological Therapies for Eating Disorders

Mitchell¹,

Roerig²,

Steffen³

2013

PsycEXTRA Dataset

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Objective-To provide a comprehensive review of pharmacotherapy and other biological treatments for eating disorders. Method-Literature on this topic was systematically reviewed.Results-The bulimia nervosa literature underscores the utility of antidepressants, particularly SSRIs, in improving the symptoms of the disorder. The literature on binge eating disorder supports efficacy on reduction in binge eating frequency for a variety of compounds. However, such compounds have only modest effects on weight. Certain antiepileptic agents such as topiramate, if tolerated, are probably more useful in terms of weight loss. The number of controlled trials in patients with anorexia nervosa in particular has been quite small, and recent meta-analyses show disappointing results using atypical antipsychotics in anorexia nervosa.Discussion-The pharmacological treatment of eating disorders remains an underdeveloped field although drug therapy clearly plays a role in the treatment of those with bulimia nervosa and binge eating disorder. Other biological therapies have not been adequately studied.Keywords anorexia nervosa; bulimia nervosa; binge eating disorder; pharmacotherapy; drug treatmentThe purpose of this review is to briefly summarize the extant literature on the biological therapies for bulimia nervosa, binge eating disorder and anorexia nervosa. Several other recent reviews have also summarized the literature in this area and may be of interest to readers 1,2 . Pharmacotherapy of Bulimia NervosaSeveral important issues are involved in considering pharmacotherapy for bulimia nervosa (BN). First, as will be seen, the evidence in this area is limited. Many of the reports in the The most frequently studied group of agents are the SSRI antidepressants (fluoxetine -twelve trials, fluvoxamine -three trials, sertraline -one trial and citalopram -one trial) followed by the tricyclic antidepressants (TCAs: desipramine -four trials, imipramine -one trial, and amitriptyline -one trial). Two trials of reversible monoamine oxidase-A inhibitors (MAOI-A) have been reported (brofaromine and moclobemide). Lastly, the serotonin-2 receptor antagonist trazodone (in two trials) has been investigated, as has the serotonin and dopamine reuptake inhibitor bupropion (in one trial). It is important to note that bupropion is contraindicated for the treatment of BN and AN due to its seizure risk. Non-antidepressants have included the serotonin-3 receptor antagonist, ondansetron (one trial), the anticonvulsant topiramate (two trials), the serotonin augmenting agent fenfluramine, which is no longer on the market (one trial), and the androgen antagonist flutamide which was studied in combination with citalopram (see Table 1). Unfortunately, rates of achieving complete remission (abstinence from binge eating and purging) are often not reported. HHS Public Access Controlled TrialsTwenty nine double-blind, placebo controlled trials were reviewed and the type of drug, level of response and abstinence rates are summarized in Table 1. Twelve of the ...

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Section: Other Biological Therapiesmentioning

confidence: 99%

Biological Therapies for Eating Disorders

Mitchell¹,

Roerig²,

Steffen³

2013

PsycEXTRA Dataset

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“…Manipulation of bite size may be achieved through changing the shape of foods [57], using utensils that support smaller bites [51] and by changing the textures of foods to reduce eating rate and energy intake [11,58,59]. Changes to eating rate can be produced by prompting the eater via external monitors of eating rate; this has been shown to have some success in children and adults [60,61], and has been shown to be a successful weight reduction strategy among children with overweight [62] and adolescents [63]. Similarly it is possible to change eating rate indirectly through the use of food textures that are equally liked, but require longer chewing [11,13,18,43,58].…”

mentioning

confidence: 99%

A description of an ‘obesogenic’ eating style that promotes higher energy intake and is associated with greater adiposity in 4.5 year-old children: Results from the GUSTO cohort

Fogel

Goh

Fries

et al. 2017

Physiology & Behavior

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Recent findings confirm that faster eating rates support higher energy intakes within a meal and are associated with increased body weight and adiposity in children. The current study sought to * Author to whom correspondence should be addressed: Ciaran Gerard Forde; Centre for Translational Medicine, 14 Medical Drive #07-02, MD 6 Building, Yong Loo Lin School of Medicine, Singapore 117599; Tel: +65 64070104; ciaran_forde@sics.astar.edu.sg. Clinical Trial Registry Number: NCT01174875; https://clinicaltrials.gov/ Authors' Contributions: This study was conceived and designed by CGF, AF, MFFC and LRF. Clinical analyses were performed by SS, SV, AF, ATG, and CGF and data analysis and interpretation were carried out by AF and CGF. AF and CGF prepared the draft manuscript and all authors reviewed and approved the final draft. This study was given ethical approval by ethical review boards of the KK Women's and Children's Hospital and National University Hospital in Singapore.Author disclosures: Keith Godfrey, Lee Yung-Seng and Yap Seng Chong have received reimbursement for speaking at conferences sponsored by companies selling nutritional products. They are part of an academic consortium that has received research funding from Abbott Nutrition, Nestec and Danone. Lisa Fries is an employee of Nestec SA, working at the Nestlé Research Center. The other authors have no financial or personal conflict of interests. Europe PMC Funders GroupAuthor Manuscript Physiol Behav. Author manuscript; available in PMC 2018 January 01. Europe PMC Funders Author ManuscriptsEurope PMC Funders Author Manuscripts identify the eating behaviours that underpin faster eating rates and energy intake in children, and to investigate their variations by weight status and other individual differences. Children (N=386) from the Growing Up in Singapore towards Healthy Outcomes (GUSTO) cohort took part in a video-recorded ad libitum lunch at 4.5 years of age to measure acute energy intake. Videos were coded for three eating behaviours (bites, chews and swallows) to derive a measure of eating rate (g/min) and measures of eating microstructure: eating rate (g/min), total oral exposure (minutes), average bite size (g/bite), chews per gram, oral exposure per bite (seconds), total bites and proportion of active to total mealtime. Children's BMIs were calculated and a subset of children underwent MRI scanning to establish abdominal adiposity. Children were grouped into faster and slower eaters, and into healthy and overweight groups to compare their eating behaviours. Results demonstrate that faster eating rates were correlated with larger average bite size (r=0.55, p<0.001), fewer chews per gram (r=-0.71, p<0.001) and shorter oral exposure time per bite (r=-0.25, p<0.001), and with higher energy intakes (r=0.61, p<0.001). Children with overweight and higher adiposity had faster eating rates (p<0.01) and higher energy intakes (p<0.01), driven by larger bite sizes (p<0.05). Eating behaviours varied by sex, ethnicity and early feeding regimes, partial...

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“…However, just a few studies have investigated the role of common dietary behaviors in the development of obesity. Although some studies reported the positive relation between eating speed and obesity [7][8][9][10], such findings have not been confirmed by others [11]. Eating before bedtime has also been linked to weight gain [12], but not consistently [13].…”

Section: Introductionmentioning

confidence: 90%

“…Based on earlier studies [8,9,13], dietary behaviors were pre-defined and assessed in five domains (meal patterns, eating rate, intra-meal fluid intake, meal-to-sleep interval, and fatty food intake) using a self-administered questionnaire. Detailed information about the questions included in each domain as well as the response categories for each Table 1.…”

Section: Assessment Of Dietary Habitsmentioning

confidence: 99%