AlInN/GaN high electron mobility transistors (HEMTs) exhibit numerous advantages compared to other known semiconductor devices. However, it is more difficult to realize the enhancement mode (E-mode) HEMTs of AlInN/ GaN than those of the AlGaN/GaN heterostructure, because of the higher 2-dimensional electron gas density at the AlInN/GaN interface. In this work, using simulations, it is shown that the E-mode can be achieved in AlInN/ GaN HEMTs by tuning the thickness of the AlInN barrier layer to less than 1.14 nm in our investigated structure. Based on the E-mode structure, the device performance stability of Al 0.83 In 0.17 N/GaN HEMTs with different heat dissipative substrates was evaluated to explore their effect on the suppression of the self-heating behavior. The DC behavior, device temperature, lattice temperature distribution, current cutoff frequency ( f T ), unilateral powergain-cutoff frequency ( f max ), and transient response were investigated comparatively. The results indicate that the AlInN/GaN HEMTs with a free-standing GaN substrate exhibit the best performance characteristics, ie, lowest lattice temperature, highest f T , and fastest transient response, in comparison with those using the flip-chip substrate and sapphire substrate. Our simulation results suggest that the free-standing GaN substrate can significantly improve the thermal stability and other basic performance characteristics of the E-mode AlInN/GaN HEMTs.