Norman Geschwind’s contribution to the understanding of behavioral changes in temporal lobe epilepsy: The February 1974 lecture

Devinsky, Julie; Schachter, Steven

doi:10.1016/j.yebeh.2009.06.006

Cited by 37 publications

(34 citation statements)

References 30 publications

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“…Behavioural changes typically follow the onset of seizures. These changes may continue for years and gradually become more intense (9). The dramatic personality change with increased viscosity, anger, and sexuality was clearly observed in our case.…”

Section: Discussionsupporting

confidence: 64%

Abnormal Sexual Behavior During Sleep in Temporal Lobe Epilepsy: a Case Report

Pelin¹,

Yazla²

2012

Balkan Med J

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Section: Discussionsupporting

confidence: 64%

Abnormal Sexual Behavior During Sleep in Temporal Lobe Epilepsy: a Case Report

Pelin¹,

Yazla²

2012

Balkan Med J

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“…Hyper-religiosity and hypergraphia, together with irritability of varying degree, are peculiar symptoms of Geschwind Syndrome, frequently reported in TLE patients (Bear & Fedio, 1977; Waxman & Geschwind, 1974; Waxman & Geschwind, 1975; Waxman & Geschwind, 2005, see also Devinsky & Schachter, 2009). To our knowledge, only one other case report describes the combination of Geschwind Syndrome symptoms in a patient affected by a neurodegenerative disease without TLE (Postiglione et al, 2008).…”

Section: Discussionmentioning

confidence: 97%

“…Starting with their seminal works published in 1974 and 1975, Waxman and Geschwind recognized that patients affected by temporal lobe epilepsy (TLE) could develop a specific constellation of symptoms that influenced their affect, personality, and cognition (Bear & Fedio, 1977; Waxman & Geschwind, 1975; Waxman & Geschwind, 1974, see also Devinsky & Schachter, 2009). In most cases, the characteristic behavioral syndrome described is interictal (i.e., present constantly, without a specific relationship to individual seizures) and consists of the following features: hyper-religiosity (increased interest in philosophical, moral, and religious issues), hypergraphia (excessive compulsive writing often of a religious or philosophical nature), hyposexuality, and irritability of varying degrees.…”

Section: Introductionmentioning

confidence: 99%

Geschwind Syndrome in frontotemporal lobar degeneration: Neuroanatomical and neuropsychological features over 9 years

Veronelli

Makaretz

Quimby

et al. 2017

Cortex

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Geschwind Syndrome, a characteristic behavioral syndrome frequently described in patients affected by temporal lobe epilepsy, consists of the following features: hyper-religiosity, hypergraphia, hyposexuality, and irritability. Here we report the 9-year-clinical course of a case of Geschwind Syndrome that developed as a first and salient clinical expression of right temporal lobe variant of frontotemporal lobar degeneration. Only one patient affected by frontotemporal dementia has previously been shown to present with Geschwind Syndrome. MS presented at age 73 with 3 years of personality and behavioral symptoms. Her early symptoms primarily included hyper-religiosity, hypergraphia, and poor emotional regulation (irritability, impulsivity, disinhibition, egocentric behavior). Over nine years, other cognitive functions (word retrieval, memory coding and recall, set-shifting, famous face and building recognition) became affected; however, hyper-religiosity, hypergraphia, and scarce emotional control remained her most prominent deficits. Longitudinal cortical thickness and volumetric analyses revealed early atrophy in the right temporal pole, right amygdala, and right hippocampus, which progressively affected homologous regions in the left hemisphere. The present case describes an unusual clinical picture associated with frontotemporal dementia, in which the most salient symptoms originated and remained consistent with Geschwind Syndrome.

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“…He wrote so extensively that he could have been hypergraphic. Thus, it is tempting to speculate that he had an interictal behavior disorder (Geschwind syndrome) [44].…”

Section: What Was His Epilepsy Type and What Role Did The Epilepsy Pmentioning

confidence: 99%

Third International Congress on Epilepsy, Brain, and Mind: Part 2

Rektor¹,

Schachter²,

Arya³

et al. 2015

Epilepsy & Behavior

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*Corresponding author at: 165 Cambridge Street, Suite 702, Boston, MA 02114, USA. Tel.: +1 617 643 3835. sschacht@bidmc.harvard.edu (S.C. Schachter). Conflict of interestNone of the authors have any conflicts of interest to disclose. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptEpilepsyis both a disease of the brain and the mind. Here, we present the first of two papers with extended summaries of selected presentations of the Third International Congress on Epilepsy, Brain and Mind (April 3-5, 2014; Brno, Czech Republic). Epilepsy in history and the arts and its relationships with religion were discussed, as were overviews of epilepsy and relevant aspects of social cognition, handedness, accelerated forgetting and autobiographical amnesia, and large-scale brain networks.

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Norman Geschwind’s contribution to the understanding of behavioral changes in temporal lobe epilepsy: The February 1974 lecture

Cited by 37 publications

References 30 publications

Abnormal Sexual Behavior During Sleep in Temporal Lobe Epilepsy: a Case Report

Abnormal Sexual Behavior During Sleep in Temporal Lobe Epilepsy: a Case Report

Geschwind Syndrome in frontotemporal lobar degeneration: Neuroanatomical and neuropsychological features over 9 years

Third International Congress on Epilepsy, Brain, and Mind: Part 2

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