Norman Holmes Pearson on H. D.: An Interview

Pearson, Norman Holmes; Dembo, L. S.

doi:10.2307/1207690

Cited by 9 publications

(4 citation statements)

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“…Importantly, the functions of the linker molecules extend beyond payload connection and controlled release. [24,[53][54][55][56] As demonstrated in previous examples, an appropriately designed linker is also critical to the overall physicochemical properties of the whole conjugate, which control the stability of self-assembled supramolecular structure, the ability for plasma protein binding, and cell membrane interactions. [24,[54][55][56] For example, in a complexed biological environment, the molecular weight of polyethylene glycol (PEG) in a diacyl lipid-PEG-peptide conjugate controls the dedicate balance between an albuminbinding state and a membrane insertion state.…”

Section: Amphiphilic Drug Modification: Conjugation Strategies Typesmentioning

confidence: 99%

Recent Advances in the Design of Self‐Delivery Amphiphilic Drugs and Vaccines

Liu

2019

Advanced Therapeutics

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Amphiphilic drugs are molecular drugs or drug conjugates possessing both hydrophilic and lipophilic properties. Representative amphiphilic drugs are composed of a pharmaceutical payload, a linker, and an appropriate amphiphilic modification. The physicochemical properties of amphiphilic drugs can be tailored by structure‐based engineering, which ultimately determine the drug molecules’ self‐assemble ability, bioavailability, protein binding, membrane anchoring, organ and intracellular distributions, side effects, and biological efficacy. Unlike the traditional carrier‐assistant drug delivery system, many of the amphiphilic drugs are carrier‐free and can self‐deliver to target sites/cells and access intracellular organelles without an external delivery carrier. This is achieved by molecular designs that control the delivery pathways of amphiphilic drugs at organ/tissue, cellular, and intracellular levels. In this review the recent advances in self‐delivery amphiphilic drugs and vaccines are highlighted, with emphasis on the underlying design principles and emerging applications.

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Section: Amphiphilic Drug Modification: Conjugation Strategies Typesmentioning

confidence: 99%

Recent Advances in the Design of Self‐Delivery Amphiphilic Drugs and Vaccines

Liu

2019

Advanced Therapeutics

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“…The chief original goal of the survey was to provide a relatively shallow Herschel survey over a very large area of sky, with the specific aims of providing measurements of the dust masses and dust-obscured star formation rate for tens of thousands of nearby galaxies (Dunne et al 2011), complementing the large optical spec-troscopic surveys of the nearby Universe, such as the Sloan Digital Sky Survey (SDSS; Abazajian et al 2009) and the Galaxy and Mass Assembly project (GAMA 1 ; Driver et al 2009;Liske et al 2015). However, the exceptional sensitivity of Herschel, aided by the large and negative k−correction at submillimeter wavelengths (Blain & Longair 1993), has meant that a significant fraction of the sources in H-ATLAS actually lie at high redshift (Amblard et al 2010;Lapi et al 2011;González-Nuevo et al 2012;Pearson et al 2013). The H-ATLAS survey is therefore useful both to astronomers studying the nearby Universe and to those studying the early (z > 1) Universe.…”

Section: Introductionmentioning

confidence: 99%

TheHerschel -ATLAS data release 1 – I. Maps, catalogues and number counts

Valiante

Smith

Eales

et al. 2016

Mon. Not. R. Astron. Soc.

207

291

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We present the first major data release of the largest single key-project in area carried out in open time with the Herschel Space Observatory. The Herschel Astrophysical Terahertz Large Area Survey (H-ATLAS) is a survey of 600 deg 2 in five photometric bands -100, 160, 250, 350 and 500 µm -with the PACS and SPIRE cameras. In this paper and a companion paper (Bourne et al. 2016) we present the survey of three fields on the celestial equator, covering a total area of 161.6 deg 2 and previously observed in the Galaxy and Mass Assembly (GAMA) spectroscopic survey. This paper describes the Herschel images and catalogues of the sources detected on the SPIRE 250 µm images. The 1σ noise for source detection, including both confusion and instrumental noise, is 7.4, 9.4 and 10.2 mJy at 250, 350 and 500 µm. Our catalogue includes 120230 sources in total, with 113995, 46209 and 11011 sources detected at > 4σ at 250, 350 and 500 µm. The catalogue contains detections at > 3σ at 100 and 160 µm for 4650 and 5685 sources, and the typical noise at these wavelengths is 44 and 49 mJy. We include estimates of the completeness of the survey and of the effects of flux bias and also describe a novel method for determining the true source counts. The H-ATLAS source counts are very similar to the source counts from the deeper HerMES survey at 250 and 350 µm, with a small difference at 500 µm. Appendix A provides a quick start in using the released datasets, including instructions and cautions on how to use them.

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“…We do not yet have a good history of cigarette patriotism, though Louis Kyriakoudes’s forthcoming book ( Why We Smoke ) should help. We need to know more about how and why cigarette makers collaborated for so many years with medical professionals: even JAMA , until 1954, was full of ads for cigarettes, and from 1964 to 1976, the AMA received nearly $20 million from the industry (for education and research), creating what journalists even at the time ridiculed as “the weirdest lobbying alliance in legislative history.”…”

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confidence: 99%