Normativa para el diagnóstico y seguimiento de la silicosis

Álvarez, Ramón Fernández; González, Cristina Martínez; Martínez, Aida Quero; Pérez, José Jesús Blanco; Fernández, L.M. Rodríguez; Fernández, Amador Prieto

doi:10.1016/j.arbres.2014.07.010

Cited by 57 publications

(6 citation statements)

References 16 publications

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“…La exposición al polvo inorgánico no es el único determinante para el desarrollo de la Neumoconiosis, Fernández et al (2015) en su estudio hablan de susceptibilidad individual, refiriéndose a la "pérdida de la eficacia de los mecanismos de defensa (…). Ello puede estar influido (…) por factores [nocivos] como el tabaquismo" (p. 88).…”

Section: Revista Biumarunclassified

Factores de Riesgo y Neumoconiosis Asociados a la Minería

et al. 2018

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La neumoconiosis está ligada a la práctica de minería; por ello, la presente investigación se realizó con la población minera artesanal del municipio de la Llanada, perteneciente a la cooperativa Codmilla Ltda., con el fin de determinar factores de riesgo y características sociolaborales asociados a la predisposición de la afección. Se realizó una encuesta de características sociolaborales y la GTC 45, en las cuales se tuvo en cuenta las variables: puesto de trabajo, nivel de riesgo al factor químico, uso inadecuado de equipos de protección personal, consumo de cigarrillo, estrato, género y los años que el sujeto lleva trabajando en minería, con el fin de determinar el porcentaje posible de población que tiene riesgo alto y medio, y que cumple con todos los criterios para padecer la enfermedad; además, para que los habitantes tengan conocimiento de la situación y así generar un impacto positivo.

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Section: Revista Biumarunclassified

Factores de Riesgo y Neumoconiosis Asociados a la Minería

et al. 2018

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“…The risk of CWP was positively related with the increased exposure to coal dust, so the prevention of dust exposure is a crucial work. Technical methods to decrease dust concentrations in the workplaces are the most effective measures, such as wet working and cleaning dust [8]. The regular measurements to monitor the total and respirable dust in the workplaces are still the essential supervision methods.…”

Section: Introductionmentioning

confidence: 99%

Effects of occupational exposure to dust on chest radiograph, pulmonary function, blood pressure and electrocardiogram among coal miners in an eastern province, China

Han

et al. 2019

BMC Public Health

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Background Coal dust is one of the most serious risk factor that leads to respiratory diseases and cardiovascular diseases in miners. This study aimed to observe the effects of occupational dust exposure on chest radiograph, pulmonary function (PF), blood pressure (BP) and electrocardiogram (ECG) indexes in coal miners and explore the related risk factors. Methods In the Chinese Occupational Disease Monitoring and Occupational Health Risk Assessment Program, a total of 11,061 subjects in 2015 and 12,597 subjects in 2016 were recruited in this study. The chest radiograph, PF, BP and ECG of coal miners were surveyed using radiograph machine, spirometer, sphygmomanometer and electrocardiograph, respectively. Results The prevalence of aberrant BP was the highest in coal miners, followed by abnormal ECG, PF and radiograph. Significant differences in abnormal BP, ECG, PF and radiograph of coal miners were closely associated with age, years of dust exposure, smoking, drinking, working types and size of mines. A total of 80 persons diagnosed with coal workers’ pneumoconiosis (CWP) in 2015–2016, which occupied 0.34% of the coal miners. Conclusion Abnormal BP, ECG, PF and radiograph of coal miners are highlighted health problems in China and require serious attention. Feasible health promotion and protective facilities should be adopted to guarantee coal miners’ health. Electronic supplementary material The online version of this article (10.1186/s12889-019-7568-5) contains supplementary material, which is available to authorized users.

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“…Furthermore, exposure, although important, is not the only determinant of silicosis severity, since commonly in workers the dose‐response relationship is not met. There are cases of enhanced susceptibility to low doses and others of high tolerance to large exposures . Individual susceptibility is related to the deposition and persistence of inhaled dust in the organism, due to loss of effectiveness of the host defense and clearance mechanisms.…”

Section: Introductionmentioning

confidence: 99%

“…Individual susceptibility is related to the deposition and persistence of inhaled dust in the organism, due to loss of effectiveness of the host defense and clearance mechanisms. Therefore, this susceptibility may be influenced by genetic factors influencing these mechanisms …”

Section: Introductionmentioning

confidence: 99%

Interleukin 1α and 1β gene variations are associated with tuberculosis in silica exposed subjects

Salum

Castro

Moreira

et al. 2019

American J Industrial Med

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Introduction: Silicosis is a fibrotic lung disease resulting from the inhalation of crystalline silica and can be classified as simple or complicated according to the International Labour Organization criteria. Furthermore, individuals exposed to crystalline silica also have a higher risk for the development of tuberculosis (Tb).The contribution of inflammatory cytokines to the risk of silicosis and Tb in different populations has previously been reported. Since genetic background might be related to susceptibility to silicosis and Tb, the study of polymorphisms within IL-1α, IL-1β, and tumor necrosis factor protein-coding genes may contribute to elucidating the genetic basis of these diseases.Methods: Single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction using restriction fragment length polymorphism or by Taqman methodology, in a sample of 102 silica-exposed patients from Brazil.Results: No significant associations were observed between the SNPs studied and the severity of silicosis. However, significant associations were found between Tb and the C allele (odds ratio [OR] = 1.93, 95% confidence interval [CI], 1.01-3.73) and the CC genotype (OR = 2.34, 95% CI, 1.04-5.31) of IL1A −899C>T. The IL1B +3954C>T polymorphism also showed an association with Tb (T allele dominant model OR = 2.38, 95% CI, 1.04-5.41). Conclusion:These preliminary results demonstrate that the IL1A and IL1B gene variations may contribute to some extent to susceptibility to Tb, but not silicosis.However, additional studies are still needed to confirm these results.

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Normativa para el diagnóstico y seguimiento de la silicosis

Cited by 57 publications

References 16 publications

Factores de Riesgo y Neumoconiosis Asociados a la Minería

Factores de Riesgo y Neumoconiosis Asociados a la Minería

Effects of occupational exposure to dust on chest radiograph, pulmonary function, blood pressure and electrocardiogram among coal miners in an eastern province, China

Interleukin 1α and 1β gene variations are associated with tuberculosis in silica exposed subjects

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