Normative Bone Mineral Density Z-Scores for Canadians Aged 16 to 24 Years: The Canadian Multicenter Osteoporosis Study

Zhou, Wei; Langsetmo, Lisa; Berger, Claudie; Adachi, Jonathan D.; Παπαϊωάννου, Αλεξάνδρα; Ioannidis, George; Webber, Colin E.; Atkinson, Stephanie A.; Olszynski, Wojciech P.; Brown, Jacques P.; Hanley, David A.; Josse, Robert G.; Kreiger, Nancy; Prior, Jerilynn C.; Kaiser, Stéphanie; Kirkland, Susan; Goltzman, David; Davison, K. Shawn

doi:10.1016/j.jocd.2010.04.005

Cited by 13 publications

(6 citation statements)

References 39 publications

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“…The risk of development of conditions related to regimen longterm toxicities (cardiovascular disease, bone fractures, and CKD) was also captured in the model. Data on key biomarkers were collected from the SWORD trial 13,14 and the literature [20][21][22] and used to inform the risk of development of long-term toxicities depending on the treatment arm.…”

Section: Model Outcomesmentioning

confidence: 99%

Cost-Effectiveness of Juluca for Human Immunodeficiency Virus Infection Treatment in Virologically Suppressed Adults in Taiwan

Anderson

Hsu²,

et al. 2021

Value in Health Regional Issues

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Section: Model Outcomesmentioning

confidence: 99%

Cost-Effectiveness of Juluca for Human Immunodeficiency Virus Infection Treatment in Virologically Suppressed Adults in Taiwan

Anderson

Hsu²,

et al. 2021

Value in Health Regional Issues

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“…Overall, BMD values in PEAK-25 were similar or significantly higher compared to similarly aged international cohorts [7,8,10,11,[14][15][16][17][18]]. This suggests that lower peak bone mass does not simply explain the observed high fracture incidence later in life.…”

Section: Discussionmentioning

confidence: 94%

“…We compared the PEAK-25 BMD data with other studies reporting normative values for similarly aged women [7,8,10,11,[14][15][16][17][18], using the entire comparative cohort or a subgroup meeting the age criteria (25y±1y). When mean age was unavailable, the age-range was calculated as (low+high/2), to be within age 24-26. As individual BMD data was not available for the comparative cohorts, standardized BMD (sBMD) values were calculated using the formula sBMD = α + β × BMD [19,20].…”

Section: Comparisons Of Normative Valuesmentioning

confidence: 99%

“…Since peak BMD is strongly influenced by age, sex, geographical location and ethnicity, it is necessary to establish relevant normative values of bone mass from which the relative scores are calculated [6][7][8][9][10][11][12]. In particular, it is important to evaluate the relevance of the NHANES III values, since they constitute the WHO diagnostic reference.…”

Section: Introductionmentioning

confidence: 99%

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Country-Specific Young Adult Dual-Energy X-Ray Absorptiometry Reference Data Are Warranted for T-Score Calculations in Women: Data From the Peak-25 Cohort

Callréus

McGuigan

Åkesson

2014

Journal of Clinical Densitometry

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The aims of this study were to provide normative data for dual energy X-ray absorptiometry (DXA) in 25 year old women and evaluate whether young adult Swedish women have bone mineral density (BMD) comparable to DXA manufacturer reference values and other equivalent populations. BMD at all sites was measured in the population-based PEAK-25 cohort (n=1061 women; age 25.5±0.2). BMD values were standardized (sBMD) and compared against NHANES III and other cohorts. Based on the DXA manufacturer supplied reference values, Z-scores were 0.54±0.98 (femoral neck; FN), 0.47±0.96 (total hip; TH) and 0.32±1.03 (lumbar spine; LS). In comparison to other studies, sBMD was higher in the PEAK-25 cohort (FN 1.5-8.3%), (TH 3.9-9.2%), (LS 2.4-6.5%) with the exception of TR-sBMD (trochanter) which was 2.5% lower compared to NHANES III. The concordance in identifying those in the lowest or highest quartile of BMD was highest between hip measurements (low 71-78%; high 70-84%), corresponding discordance 0-1%. At this age the correlation between DXA sites was strong (r=0.62-0.94). BMD in Swedish young adult women is generally higher than has been reported in other equivalently aged European and North American cohorts and suggests that that the high fracture incidence in Sweden is not explained by lower peak bone mass. The use of non-regional specific DXA reference data could contribute to misdiagnosed osteoporosis in elderly women.

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“…BMD declines rapidly with age, leaving older adults most susceptible to fractures [ 1 ]. Typically, BMD is represented either absolutely (in g/cm 2 ), or by a Z-score, which compares an individual’s BMD to the average values for a healthy person of the same age and sex [ 2 ]. Osteoporosis, a disease characterized by bone loss and deterioration of bone structure, is the leading cause of fractures in the U.S. and affects almost 20% of women and 5% of men aged 50 and over [ 1 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Phthalates and bone mineral density: a systematic review

2022

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Background Exposure to endocrine disruptors, such as phthalates, may impact bone mineral density (BMD) through a variety of mechanisms. Studies of phthalate exposure and BMD in humans are scarce. Objectives To synthesize published data on the association between phthalate metabolites and BMD in humans and to provide methodological suggestions for future research. Methods A single investigator searched PubMed for relevant studies, including observational studies of phthalate exposure and BMD in children and postmenopausal women. Twelve studies were screened with 5 meeting the eligibility criteria and included for review. A quality assessment form was used as a quality measure and key information was extracted from the included studies. Results In one prospective study among postmenopausal women, higher levels of monocarboxyoctyl phthalate (MCOP) and monocarboxynonyl phthalate (MCNP) were significantly associated with lower BMD among nonusers of hormone therapy (HT). In cross-sectional studies of postmenopausal women, monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), mono (3-carboxypropyl) phthalate (MCPP), and mono-benzyl phthalate (MBzP) were negatively associated with BMD, and MCNP was positively associated with BMD, but these results were not replicated across studies. In studies of fetal exposure to phthalates and childhood BMD, significant positive associations between MCPP and BMD in children at age 12 years were found in 1 study, while associations were null in the other study. Conclusions Studies among postmenopausal women provide suggestive evidence of an association between urinary phthalate metabolite concentration and decreased BMD. Results from studies of childhood BMD are inconclusive given the limited data and their limitations. More research is needed to address limitations and further investigate the association between phthalate exposure and human BMD.

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Normative Bone Mineral Density Z-Scores for Canadians Aged 16 to 24 Years: The Canadian Multicenter Osteoporosis Study

Cited by 13 publications

References 39 publications

Cost-Effectiveness of Juluca for Human Immunodeficiency Virus Infection Treatment in Virologically Suppressed Adults in Taiwan

Cost-Effectiveness of Juluca for Human Immunodeficiency Virus Infection Treatment in Virologically Suppressed Adults in Taiwan

Country-Specific Young Adult Dual-Energy X-Ray Absorptiometry Reference Data Are Warranted for T-Score Calculations in Women: Data From the Peak-25 Cohort

Phthalates and bone mineral density: a systematic review

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