Normative Data for Digital X-Ray Radiogrammetry From a Female and Male German Cohort

Böttcher, Joachim; Pfeil, Alexander; Schäfer, M.; Petrovitch, A.; Seidl, Bettina E.; Mentzel, Hans‐Joachim; Lehmann, G.; Malich, Ansgar; Heyne, Jens-Peter; Hein, Gert; Wolf, Günter; Kaiser, Werner A.

doi:10.1016/j.jocd.2006.05.010

Cited by 29 publications

(42 citation statements)

References 33 publications

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“…From our data, a mean agerelated increase in metacarpal total CSA of approximately 1 mm 2 per decade in healthy controls can be derived (data not shown). This is comparable to the increase of approximately 0.1 mm per decade found in a normative data study for metacarpal bone width in men (18). However, we found significantly steeper slopes for age-related decreases in cortical CSA, cortical thickness, and the MI in the RA compared to the control group (Table 2 and Figures 2A and B).…”

Section: Discussionsupporting

confidence: 88%

“…Age-related thinning of the cortex and an increase in the outer bone circumference has been documented in healthy populations at the shafts of the tibia (35,36), radius (37), and metacarpal bone (18,38). From our data, a mean agerelated increase in metacarpal total CSA of approximately 1 mm 2 per decade in healthy controls can be derived (data not shown).…”

Section: Discussionmentioning

confidence: 55%

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Abnormal bone geometry at the metacarpal bone shaft of rheumatoid arthritis patients with maintained muscle–bone relationship

Eser¹,

Aeberli²,

Widmer³

et al. 2011

Arthritis Care & Research

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 55%

Abnormal bone geometry at the metacarpal bone shaft of rheumatoid arthritis patients with maintained muscle–bone relationship

Eser¹,

Aeberli²,

Widmer³

et al. 2011

Arthritis Care & Research

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“…It is also important to note the influence of normal age-related bone loss that takes place in healthy adults, especially postmenopausal women. Normal bone loss for DXR–MCI has only been examined in cross-sectional studies reporting an annual rate of bone loss between 0.7% and 0.9% 21 38 39…”

Section: Discussionmentioning

confidence: 99%

Adalimumab therapy reduces hand bone loss in early rheumatoid arthritis: explorative analyses from the PREMIER study

Hoff

Kvien

Kälvesten

et al. 2008

Annals of the Rheumatic Diseases

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Objective:The effect of adalimumab on hand osteoporosis was examined and related to radiographic joint damage in the three treatment arms of the PREMIER study: adalimumab plus methotrexate, adalimumab and methotrexate monotherapy. Predictors of hand bone loss were also searched for.Methods:768 patients (537 fulfilled 2 years) with rheumatoid arthritis (RA) for less than 3 years, never treated with methotrexate, were included. Hand bone loss was assessed by digital x ray radiogrammetry (DXR) on the same hand radiographs scored with modified Sharp score at baseline, 26, 52 and 104 weeks. For DXR, metacarpal cortical index (MCI) was the primary bone measure.Results:At all time points the rate of percentage DXR–MCI loss was lowest in the combination group (−1.15; −2.16; −3.03) and greatest in the methotrexate monotherapy group (−1.42; −2.87; −4.62), with figures in between for the adalimumab monotherapy group (−1.33; −2.45; −4.03). Significant differences between the combination group and the methotrexate group were seen at 52 (p = 0.009) and 104 weeks (p<0.001). The order of hand bone loss across the three treatment arms was similar to the order of radiographic progression. Older age, elevated C-reactive protein and non-use of adalimumab were predictors of hand bone loss.Conclusion:This study supports a similar pathogenic mechanism for hand bone loss and erosions in RA. The combination of adalimumab and methotrexate seems to arrest hand bone loss less effectively than radiographic joint damage. Quantitative measures of osteoporosis may thus be a more sensitive tool for assessment of inflammatory bone involvement in RA.

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“…A large body of comparative clinical data from modern populations is also available (e.g. Virtama and Helela, 1969;Böttcher et al, 2006). Several quantitative techniques to assess bone mass have been devised.…”

Section: Introductionmentioning

confidence: 99%

An investigation of cortical bone loss and fracture patterns in the neolithic community of Çatalhöyük, Turkey using metacarpal radiogrammetry

Glencross

2011

Journal of Archaeological Science

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Normative Data for Digital X-Ray Radiogrammetry From a Female and Male German Cohort

Cited by 29 publications

References 33 publications

Abnormal bone geometry at the metacarpal bone shaft of rheumatoid arthritis patients with maintained muscle–bone relationship

Abnormal bone geometry at the metacarpal bone shaft of rheumatoid arthritis patients with maintained muscle–bone relationship

Adalimumab therapy reduces hand bone loss in early rheumatoid arthritis: explorative analyses from the PREMIER study

An investigation of cortical bone loss and fracture patterns in the neolithic community of Çatalhöyük, Turkey using metacarpal radiogrammetry

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