Normative data of a brief neuropsychological battery for Spanish individuals older than 49

Alegret, Montserrat; Espinosa, Ana; Vinyes-Junqué, Georgina; Valero, Sergi; Hernández, Isabel; Tárraga, Lluís; Becker, James T.; Boada, Merçé

doi:10.1080/13803395.2011.630652

Cited by 71 publications

(84 citation statements)

References 36 publications

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“…To aid this process, projects like the Spanish Multicenter Normative Studies (NEURONORMA) have been adapting English language tests for the Spanish-speaking population [10], [11], [12], [13], [14]. A few neuropsychological screening batteries, adapted for Spanish-speaking individuals, have also been adapted to include age and education adjusted normative values [15], [16], [17], [18], [19]. All of these tests were standardized by administering them to a representative sample of cognitively healthy individuals to establish normative scores.…”

Section: Introductionmentioning

confidence: 99%

Cut-off Scores of a Brief Neuropsychological Battery (NBACE) for Spanish Individual Adults Older than 44 Years Old

et al. 2013

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The neuropsychological battery used in Fundació ACE (NBACE) is a relatively brief, and easy to administer, test battery that was designed to detect cognitive impairment in the adulthood. The NBACE includes measures of cognitive information processing speed, orientation, attention, verbal learning and memory, language, visuoperception, praxis and executive functions. The aim of the present study was to establish the cut-off scores for impairment for different levels of age and education that could be useful in the cognitive assessment of Spanish subjects who are at risk for cognitive impairment, especially dementia. Data from 1018 patients with a mild dementia syndrome, and 512 cognitively healthy subjects, older than 44 years, from the Memory Clinic of Fundació ACE (Barcelona, Spain) were analyzed. In the whole sample, cut-off scores and sensitivity/specificity values were calculated for six conditions after combining 3 age ranges (44 to 64; 65 to 74; and older than 74 years old) by 2 educational levels (until Elementary school; and more than Elementary school). Moreover, general cut-offs are reported for Catalan and Spanish speakers. The results showed that most of NBACE tests reached good sensitivity and specificity values, except for Ideomotor praxis, Repetition and Verbal Comprehension tests, which had a ceiling effect. Word List Learning from the Wechsler Memory Scale-III and Semantic Verbal Fluency were the most useful tests to discriminate between cognitively healthy and demented subjects. The NBACE has been shown to be a useful tool able to detect cognitive impairment, especially dementia, in older than 44 years Spanish persons.

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Section: Introductionmentioning

confidence: 99%

Cut-off Scores of a Brief Neuropsychological Battery (NBACE) for Spanish Individual Adults Older than 44 Years Old

et al. 2013

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“…The neuropsychological battery has been described in detail previously (see previous studies [18, 48] for details) and it includes measures sensitive to orientation, attention, verbal and visual long-term memory, language, visual gnosis, praxis and executive functions. The tests were: Temporal, Spatial and Personal Orientation; Digit span forwards and backwards, Block Design and Similarities subtests of Wechsler Adult Intelligence Scale-Third Edition (WAIS-III); The Word List Learning test from the Wechsler Memory Scale-Third Edition (WMS-III), including a recognition task; the Long-term Visual Memory subtest of The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), including a recognition task; Verbal comprehension (2 simple, 2 semi-complex and 2 complex commands); an abbreviated 15 item confrontation naming test from the Boston Naming Test; the Poppelreuter test; Luria’s Clock test; Ideomotor and Imitation praxis; the Automatic Inhibition subtest of the Syndrom Kurtz Test (SKT); Phonetic Verbal Fluency (words beginning with ‘P’ during one minute); Semantic Verbal Fluency (‘animals’ during one minute), and the Spanish version of the Clock Test.…”

Section: Methodsmentioning

confidence: 99%

Cognitive, Genetic, and Brain Perfusion Factors Associated with Four Year Incidence of Alzheimer's Disease from Mild Cognitive Impairment

Alegret

Cuberas-Borrós

Espinosa

et al. 2014

JAD

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Background There is a range of factors that predict the development of Alzheimer’s disease (AD) dementia among patients with amnestic Mild Cognitive Impairment (MCI). Objectives To identify the neuropsychological, genetic and functional brain imaging data that best predict conversion to AD dementia in patients with amnestic MCI. Methods From an initial group of 42 amnestic MCI patients assessed with neurological, neuropsychological and brain SPECT, 39 (25 converters, 14 non-converters) were followed for 4 years, and 36 had APOE ε4 genotyping. Baseline neuropsychological data and brain SPECT data were used to predict which of the MCI patients would develop dementia by the end of the 4 years of observation. Results The MCI patients who had converted to AD dementia had poorer performance on long-term visual memory and Semantic Fluency tests. The MCI subjects who developed dementia were more likely to carry at least one copy of the APOE ε4 allele (Hazard Risk = 4.22). There was lower brain perfusion in converters than non-converters, mainly in postcentral gyrus. An additional analysis of the SPECT data found differences between the MCI subjects and controls in the posterior cingulate gyrus and the basal forebrain. When the brain imaging and neuropsychological test data were combined in the same Cox regression model, only the neuropsychological test data were significantly associated with time to dementia. Conclusion Although the presence of reduced brain perfusion in postcentral gyrus and basal forebrain indicated an at-risk condition, it was the extent of memory impairment that was linked to the speed of decline from MCI to AD.

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“…Baseline signs and symptoms are acquired directly from the patient or from the primary caregiver. The patients were administered a neuropsychological battery [27] that included measures sensitive to orientation, attention, verbal learning and long-term memory, language, visuoperception, gnosis, praxis and executive functions. Neuroimaging studies were either CT and/or MR1 which is required for an FTD diagnosis [20]; in some cases SPECT scans were also available.…”

Section: Methodsmentioning

confidence: 99%

Identification of Misdiagnosed Fronto-Temporal Dementia using APOE Genotype and Phenotype-Genotype Correlation Analyses

Hernández¹,

Mauleón²,

Rosense-Roca³

et al. 2014

CAR

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Objective Postmortem and genetic studies of clinically diagnosed Frontotemporal dementia (FTD) patients suggest that a number of clinically diagnosed FTD patients are actually “frontal variants” of Alzheimer’s disease (fvAD). The purpose of this study was to evaluate this hypothesis by combining neuropathological data, genetic association studies of APOE, phenotype-APOE genotype correlations and discriminant analysis techniques. Methods Neuropathological information on 24 FTD cases, genetic association studies of APOE (168 FTD, 3083 controls and 2528 AD), phenotype-genotype correlations and discriminant techniques (LDA, logistic regression and decision trees) were combined to identify fvAD patients within a clinical FTD series. Results Four of 24 FTLD patients (16.6%) met criteria for definite AD. By comparing allele and genotype frequencies of APOE in controls, FTD and AD groups and by applying the Hardy-Weinberg equilibrium law (HWE), we inferred a consistent (17.2%) degree of AD contamination in clinical FTD. A penetrance analysis for APOE ε4 genotype in the FTD series identified 14 features for discrimination analysis. These features were compared between clinical AD (n=332) and clinical FTD series (n=168) and classifiers were constructed usinglinear discriminant analysis logistic regression or decision tree techniques. The classifier had 92.8% sensitivity to FTD and 93.4% sensitivity to AD relative to neuropathology (global AUC=0.939, p<<0.001). We identified 30 potential fvAD cases (17.85%) in the clinical FTD sample. Conclusion The APOE locus association in clinical FTD might be entirely explained by the existence of “hidden” fvAD cases within an FTD sample. The degree of fvAD contamination can be inferred from APOE genotypes.

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Normative data of a brief neuropsychological battery for Spanish individuals older than 49

Cited by 71 publications

References 36 publications

Cut-off Scores of a Brief Neuropsychological Battery (NBACE) for Spanish Individual Adults Older than 44 Years Old

Cut-off Scores of a Brief Neuropsychological Battery (NBACE) for Spanish Individual Adults Older than 44 Years Old

Cognitive, Genetic, and Brain Perfusion Factors Associated with Four Year Incidence of Alzheimer's Disease from Mild Cognitive Impairment

Identification of Misdiagnosed Fronto-Temporal Dementia using APOE Genotype and Phenotype-Genotype Correlation Analyses

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