Normative Data of Macular Thickness Using Spectral Domain Optical Coherence Tomography for Healthy Jordanian Children

Jammal, Hisham M.; Al-Omari, Rami; Khader, Yousef

doi:10.2147/opth.s386946

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…Table 2 displays morphological and functional parameters in XLRS patients, grouped by age at baseline. In the pediatric/adolescent group (0–18 years), the retina was notably thicker compared to normative values ( 16 ), with the best BCVA among the three age group cohorts. Patients in the middle-age group (18–40 years) exhibited retinal thickness similar to the pediatric/adolescent group; however, BCVA was lower in both eyes when compared with the pediatric/adolescent group.…”

Section: Resultsmentioning

confidence: 81%

Morphological and functional parameters in X-linked retinoschisis patients–A multicentre retrospective cohort study

Kiraly,

Seitz,

Abdalla Elsayed

et al. 2024

Front. Med.

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IntroductionX-linked retinoschisis (XLRS) is a potential target for gene supplementation approaches. To establish potential structural and functional endpoints for clinical trials, a comprehensive understanding of the inter-eye symmetry, relationship between structural and functional parameters, and disease progression is vital.MethodsIn this retrospective multicentre study, 118 eyes of 59 XLRS patients with RS1 mutations were assessed. Information from center databases included: RS1 variant; age at presentation; best-corrected visual acuity (BCVA), central retinal thickness (CRT), macular volume (MV) at presentation and at the last follow up; full-field electroretinogram (ERG) findings; presence of peripheral retinoschisis and complications (vitreous hemorrhage, retinal detachment); treatment with systemic or topical carbonic anhydrase inhibitors (CAI).ResultsInter-eye symmetry revealed strong correlation in CRT (r = 0.77; p < 0.0001) and moderate correlations in MV (r = 0.51, p < 0.0001) and BCVA (r = 0.49; p < 0.0001). Weak or no correlations were observed between BCVA and structural parameters (CRT, MV). Peripheral retinoschisis was observed in 40 (68%), retinal detachment in 9 (15%), and vitreous hemorrhage in 5 (8%) patients, respectively. Longitudinal examinations (mean, 4.3 years) showed no BCVA changes; however, a reduction of the CRT (p = 0.02), and MV (p = 0.01) was observed. Oral and/or topical CAI treatment did not significantly alter the CRT (p = 0.34).DiscussionThe XLRS phenotype demonstrates a strong CRT symmetry between the eyes within individual patients and stable BCVA over several years. BCVA exhibits a weak correlation with the morphological parameters of retinal thickness (CRT MV). In our cohort, longitudinal functional changes were not significant, likely attributed to the short average follow-up period. Furthermore, CAI treatment didn’t influence both morphological and functional outcomes.

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Section: Resultsmentioning

confidence: 81%

Morphological and functional parameters in X-linked retinoschisis patients–A multicentre retrospective cohort study

Kiraly,

Seitz,

Abdalla Elsayed

et al. 2024

Front. Med.

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“…When interpreting pediatric OCT, parameters including the macula, retinal nerve fiber layer thickness and optic nerve may be adjusted according to race, axial length and age. Different research groups proposed normative databases for quantifying parameters on OCT based on different ethnicities [ 12 , 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Normal Oct and Octa In Childrenmentioning

confidence: 99%

Optical Coherence Tomography and Optical Coherence Tomography Angiography in Pediatric Retinal Diseases

et al. 2023

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Indirect ophthalmoscopy and handheld retinal imaging are the most common and traditional modalities for the evaluation and documentation of the pediatric fundus, especially for pre-verbal children. Optical coherence tomography (OCT) allows for in vivo visualization that resembles histology, and optical coherence tomography angiography (OCTA) allows for non-invasive depth-resolved imaging of the retinal vasculature. Both OCT and OCTA were extensively used and studied in adults, but not in children. The advent of prototype handheld OCT and OCTA have allowed for detailed imaging in younger infants and even neonates in the neonatal care intensive unit with retinopathy of prematurity (ROP). In this review, we discuss the use of OCTA and OCTA in various pediatric retinal diseases, including ROP, familial exudative vitreoretinopathy (FEVR), Coats disease and other less common diseases. For example, handheld portable OCT was shown to detect subclinical macular edema and incomplete foveal development in ROP, as well as subretinal exudation and fibrosis in Coats disease. Some challenges in the pediatric age group include the lack of a normative database and the difficulty in image registration for longitudinal comparison. We believe that technological improvements in the use of OCT and OCTA will improve our understanding and care of pediatric retina patients in the future.

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Evaluating retinal thickness classification in children: A comparison between pediatric and adult optical coherence tomography databases

Pua,

Hairol

2024

PLoS ONE

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Purpose This study investigates the agreement of children’s retinal thickness classification by color category between Topcon 3D OCT-1’s built-in adult reference data and our new pediatric database and assesses the correlation of retinal thickness with age and spherical equivalent (SE). Methods 160 eyes of 160 healthy children (74 boys, 86 girls) aged 6–18 years (mean: 11.60 ± 3.28 years) were evaluated in this cross-sectional study. The peripapillary retinal nerve fibre layer (pRNFL) and macular thickness were determined for the 1st, 5th, 95th, and 99th percentile points. Cohen’s κ value and specific agreement between pediatric data and adult reference database were estimated. The correlation between retinal thickness with age and SE was also determined. Results The mean thickness for the total RNFL, average macular, and central macula were 112.05±8.65 μm, 280.24±12.46 μm, and 220.55±17.53 μm, respectively. The overall agreement between the classification of the adult database and pediatric data for pRNFL was ≥90%, with discrepancies in 46 out of 150 eyes (30.67%); for macula, it was above 72%, with discrepancies in 93 out of 153 eyes (60.78%); and for ganglion cell complex and ganglion cell + inner plexiform layer (GCIPL) the agreement was above 84% and 85%, respectively. A significant level of agreement between pediatric data and adult reference data was achieved for temporal RNFL (κ = 0.65), macular perifoveal superior (κ = 0.67), and inferior (κ = 0.63) and inferior GCIPL (κ = 0.67). The correlations between age and retinal thickness were not significant (all p>0.05). Most retinal thickness parameters were positively associated with SE (Pearson’s coefficient, r = 0.26 to 0.49, all p<0.05). Conclusions The overall agreement for pRNFL and macular thickness measurements in children with the adult reference database was between 72% and 90%. Children’s retinal thickness was not significantly correlated with age but was positively associated with spherical equivalent.

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Normative Data of Macular Thickness Using Spectral Domain Optical Coherence Tomography for Healthy Jordanian Children

Cited by 3 publications

References 31 publications

Morphological and functional parameters in X-linked retinoschisis patients–A multicentre retrospective cohort study

Morphological and functional parameters in X-linked retinoschisis patients–A multicentre retrospective cohort study

Optical Coherence Tomography and Optical Coherence Tomography Angiography in Pediatric Retinal Diseases

Evaluating retinal thickness classification in children: A comparison between pediatric and adult optical coherence tomography databases

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