Normative hypogonadism and depression: does ‘andropause’ exist?

Seidman, Stuart N.

doi:10.1038/sj.ijir.3901443

Cited by 22 publications

(21 citation statements)

References 62 publications

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“…In comparison to menopause, a phenomenon called andropause has begun to be described for males, but this hormonal shift has not been scientifically shown to exist to a similar extent as menopause [28] . Men are confronted with hormonal changes, but these changes are not as abrupt or of as great a magnitude as hormonal changes in women.…”

Section: The Role Of Hormonesmentioning

confidence: 99%

Geropsychology: The Gender Gap in Human Aging – A Mini-Review

Kryspin-Exner

Lamplmayr

Felnhofer³

2010

Gerontology

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Differences between women and men in terms of gender gaps at late stages of their lives are the focus of this mini-review. We approach the matter by taking up the position of complex yet promising standpoints, the bio-psycho-social perspective on the one hand and approaches of developmental psychology on the other. Lifespan perspectives and the brain-behavior relationship are integrated and applied to geropsychological models. Research on gender differences is presented and examined, particularly regarding physiological and psychological differences between aging men and women; additionally, gender discrepancies in psychopathology are discussed. Prevailing concepts of ‘active aging’ are introduced and their implications for the review of divergent gender differences are considered.

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Section: The Role Of Hormonesmentioning

confidence: 99%

Geropsychology: The Gender Gap in Human Aging – A Mini-Review

Kryspin-Exner

Lamplmayr

Felnhofer³

2010

Gerontology

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“…Other studies were unable to document a substantial effect of testosterone administration to hypogonadal men with depression [48,49]. These conflicting results may be (partially) explained by the different operational definitions of depression (mood disturbances, dysthymia, severe depression, and even more importantly, by the inclusion criteria with regard to plasma testosterone levels at entry to the study.…”

Section: Testosterone and Mood And Depressionmentioning

confidence: 80%

Testosterone and the brain

Gooren¹

2007

The Journal of Men's Health & Gender

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The effects of testosterone on sexual appetite are obvious. Furthermore, treatment of hypogonadal men with testosterone leads almost always to unmistakable positive changes in mood, self-esteem and vitality. This testifies to the profound effects testosterone exerts on the brain and the mind. Conversely, hypogonadism and particularly the profound hypogonadism resulting from androgen deprivation treatment in men with prostate cancer, is associated with loss of vitality and mood disorders, if not depression. Several studies have found a role for testosterone on cognition (particularly visuo-spatial abilities), mood and depression, and low testosterone values may predict the development of Alzheimer's disease. Testosterone administration to hypogonadal men supports this notion. But not all studies have been able to confirm the association between testosterone and mental functions. These discrepancies might be explained by the large variations in design, inclusion criteria with regard to threshold values of testosterone, duration of study and psychometric instruments. It is likely that men with plasma testosterone values below the lower limit of normal will benefit (most). It is presently not justified to prescribe testosterone as a primary treatment for men with impaired cognitive functioning or mood disorders. These complaints are common in elderly men, and one of the diagnostic considerations might be testing for testosterone deficiency as an etiological factor, and if, upon laboratory measurement, testosterone levels are truly hypogonadal, testosterone treatment is warranted. This probably will not only benefit mental functioning but there will be somatic benefits as well as a result of normalization of testosterone levels. ß 2007 WPMH GmbH. Published by Elsevier Ireland Ltd.Mind-body interaction is evidently fundamental to human existence. But medicine has followed the Cartesian tradition of the split of the body and the mind. The body and the mind have subsequently become the domains of different scientific disciplines, each with different concepts and methodologies and it has been difficult to integrate their insights into one science. However, as a counter current, over the last 50 years psychosomatic medicine has promoted the scientific understanding of the interaction of body and mind, the interaction of brain and mind and the social context we live in. This has contributed to a better understanding of the pathogenesis, course and treatment of disease and has promoted health. This contribution will address the role of testosterone in the interaction of brain and mind, with a focus on the changes occurring in elderly men. The latter might be related to changes in androgen levels with aging. In an attempt to define the role of androgens in these processes, it is accepted that their effects relate to the complexity of the personality of the subjects living in their social context. Nevertheless, in spite of the fact that these processes are multifactorial it has been possible to define some elements that can be...

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“…Mood disturbance and depression are often associated with low androgen levels (105). Men receiving ADT may also experience decreases in cognitive function and selfesteem, as well as libido and sexual function (106,107).…”

Section: Moodmentioning

confidence: 99%

Ethical and Medical Considerations of Androgen Deprivation Treatment of Sex Offenders

Gooren

2011

The Journal of Clinical Endocrinology & Metabolism

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Provided that the human rights of sex offenders are respected and informed consent is given, androgen deprivation within a comprehensive framework of psychotherapeutic treatment can make a meaningful contribution to the prevention of recidivism by enabling better control of sexual impulses. Knowledge of side effects and their treatment has been mostly gleaned from experience with prostate cancer patients, and this should be made available to sex offenders undergoing androgen deprivation.

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Normative hypogonadism and depression: does ‘andropause’ exist?

Cited by 22 publications

References 62 publications

Geropsychology: The Gender Gap in Human Aging – A Mini-Review

Geropsychology: The Gender Gap in Human Aging – A Mini-Review

Testosterone and the brain

Ethical and Medical Considerations of Androgen Deprivation Treatment of Sex Offenders

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