Normative mammillary body volumes: From the neonatal period to young adult

Vann, Seralynne Denise; Zachiu, Cornel; Meys, Karlijn M.E.; Ambrosino, Sara; Durston, Sarah; Vries, Linda S. de; Groenendaal, Floris; Lequin, Maarten H.

doi:10.1016/j.ynirp.2022.100122

Cited by 5 publications

(4 citation statements)

References 36 publications

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“…As with previous studies, the left mammillary body was found to be slightly larger (6.4%) than the right in control participants 12 , 24 . In the current data set, the left mammillary body was also larger (6.96%), than the right in the patient group, whereas a previous study reported the left and right mammillary bodies to be of equivalent volumes in patients with schizophrenia 12 ; a further study did not separate mammillary body volumes by hemisphere 13 .…”

Section: Discussionsupporting

confidence: 89%

Reduced mammillary body volume in individuals with a schizophrenia diagnosis: an analysis of the COBRE data set

et al. 2023

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While the frontal cortices and medial temporal lobe are well associated with schizophrenia, the involvement of wider limbic areas is less clear. The mammillary bodies are important for both complex memory formation and anxiety and are implicated in several neurological disorders that present with memory impairments. However, little is known about their role in schizophrenia. Post-mortem studies have reported a loss of neurons in the mammillary bodies but there are also reports of increased mammillary body volume. The findings from in vivo MRI studies have also been mixed, but studies have typically only involved small sample sizes. To address this, we acquired mammillary body volumes from the open-source COBRE dataset, where we were able to manually measure the mammillary bodies in 72 individuals with a schizophrenia diagnosis and 74 controls. Participant age ranged from 18 to 65. We found the mammillary bodies to be smaller in the patient group, across both hemispheres, after accounting for the effects of total brain volume and gender. Hippocampal volumes, but not subiculum or total grey matter volumes, were also significantly lower in patients. Given the importance of the mammillary bodies for both memory and anxiety, this atrophy could contribute to the symptomology in schizophrenia.

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Section: Discussionsupporting

confidence: 89%

Reduced mammillary body volume in individuals with a schizophrenia diagnosis: an analysis of the COBRE data set

et al. 2023

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show abstract

“…As with previous studies, the left mammillary body was found to be slightly larger (6.4%) than the right in control participants (Tognin et al, 2012;Vann et al, 2022). In the current data set, the left mammillary body was also larger (6.96%), than the right in the patient group, whereas a previous study reported the left and right mammillary bodies to be of equivalent volumes in patients with schizophrenia (Tognin et al, 2012); a further study did not separate mammillary body volumes by hemisphere (Klomp et al, 2012).…”

Section: Discussionsupporting

confidence: 88%

Reduced mammillary body volume in individuals with a schizophrenia diagnosis: an analysis of the COBRE data set

Milczarek

Gilani

Lequin

et al. 2023

Preprint

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While the frontal cortices and medial temporal lobe are well-associated with schizophrenia, the involvement of wider limbic areas is less clear. The mammillary bodies are important for both complex memory formation and anxiety and are implicated in several neurological disorders that present with memory impairments. However, little is known about their role in schizophrenia. Post-mortem studies have reported both a loss of neurons in the mammillary bodies but also reports of increased mammillary body volume. The findings from in vivo MRI studies have also been mixed, but studies have typically only involved small sample sizes. To address this, we acquired mammillary body volumes from the open-source COBRE dataset, where we were able to manually measure the mammillary bodies in 72 individuals with a schizophrenia diagnosis and 74 controls. Participant age ranged from 18-65. We found the mammillary bodies to be smaller in the patient group, across both hemispheres, after accounting for the effects of total brain volume and gender. Hippocampal volumes, but not subiculum or total grey matter volumes, were also significantly lower in patients. Given the importance of the mammillary bodies for both memory and anxiety, this atrophy could contribute to the symptomology in schizophrenia.

show abstract

“…Mammillary body volumes are observed to increase until approximately 15 years old ( 53 ). Therefore, while individuals with increased symptom severity may seem to converge toward a normative pattern, the underlying functionality or efficiency of this region and its modulation of neural circuits, such as the limbic system, could still be compromised, thereby contributing to increased symptom severity.…”

Section: Discussionmentioning

confidence: 99%

The Limbic System in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder: A Longitudinal Structural Magnetic Resonance Imaging Analysis

Connaughton,

O’Hanlon,

Silk

et al. 2024

Biological Psychiatry Global Open Science

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Normative mammillary body volumes: From the neonatal period to young adult

Cited by 5 publications

References 36 publications

Reduced mammillary body volume in individuals with a schizophrenia diagnosis: an analysis of the COBRE data set

Reduced mammillary body volume in individuals with a schizophrenia diagnosis: an analysis of the COBRE data set

Reduced mammillary body volume in individuals with a schizophrenia diagnosis: an analysis of the COBRE data set

The Limbic System in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder: A Longitudinal Structural Magnetic Resonance Imaging Analysis

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