Normative Values for the Leicester Cough Questionnaire in Healthy Individuals

Reynolds, Jane; Jetté, Marie E.; Wright, Miranda L; Sundar, Krishna M.; Gillespie, Amanda I.; Slovarp, Laurie

doi:10.1177/00034894221112517

Cited by 10 publications

(9 citation statements)

References 12 publications

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“…As reflected by cough PRO scores, the severity and impact of cough was considerable even among CC patients in the community. The LCQ and HARQ scores in this study had exceeded the normative values of healthy individuals suggested from other countries [ 24 , 25 ]. We examined their healthcare journeys and found several unmet needs in physician’s knowledge and understanding of CC, diagnostic investigations, and treatment effectiveness.…”

Section: Discussioncontrasting

confidence: 71%

Cough Characteristics and Healthcare Journeys of Chronic Cough Patients in Community-Based Populations in South Korea and Taiwan

Song

Yu²,

Kang³

2022

Lung

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Purpose This study aimed to understand the cough characteristics and health journeys among community-based chronic cough (CC) patients, and their characteristics associated with healthcare visits. Methods A population-based cross-sectional study was conducted in 2020, using the South Korea and Taiwan National Health and Wellness Survey (NHWS) and CC surveys. Patients with current CC were defined by daily coughing for > 8 weeks in the past 12 months and currently coughing at the time of survey. The survey items pertained to CC patients’ treatment journey and cough characteristics. Results Patients with current CC in South Korea and Taiwan, respectively, had cough duration for 3.45 ± 5.13 years and 5.75 ± 7.28 years and cough severity visual analogue scale (VAS) scores of 4.50 ± 2.15 and 4.46 ± 1.92 out of 0–10 scale, with 70.3% and 57.9% having spoken with a physician about cough. Compared to CC patients who had not visited healthcare professionals for cough, those who visited reported more severe cough (VAS: 3.89 ± 1.71 vs. 4.6 ± 2.02; p = 0.009), worse cough-specific quality of life (Leicester Cough Questionnaire: 16.20 ± 3.23 vs.13.45 ± 2.68, p < 0.001), greater symptom severity (Hull Airway Reflux Questionnaire: 16.73 ± 15.16 vs. 24.57 ± 13.38; p < 0.001), and more urinary incontinence (13.6 vs. 26.5%, p = 0.027). More than 50% of patients perceived cough medication(s) as not or a little useful and 25% felt their physicians did not well understand how CC impacts their life. Conclusion Cough is frequently severe and persistent among community-based CC patients. They experience several issues in their health journey, including treatment ineffectiveness and physician’s understanding. Further efforts are warranted to reduce CC burden in the community.

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Section: Discussioncontrasting

confidence: 71%

Cough Characteristics and Healthcare Journeys of Chronic Cough Patients in Community-Based Populations in South Korea and Taiwan

Song

Yu²,

Kang³

2022

Lung

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“…Given this pattern, the researchers felt it prudent to refer her back to her pulmonologist. Of the five participants who completed CDT, two scored over 19 (mean change = 5.59) on total LCQ following CDT (within normal range[ 55 ]). The other three made no clinically meaningful improvement.…”

Section: Resultsmentioning

confidence: 99%

Cough desensitization treatment for patients with refractory chronic cough: results of a second pilot randomized control trial

et al. 2023

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Objective The purpose of this study was to collect pilot efficacy data on a novel treatment for refractory chronic cough (RCC), which we call cough desensitization treatment (CDT). Design and methods In this parallel cohort, sham-controlled, randomized controlled trial, 21 adults with RCC were randomly assigned to 12 sessions of either CDT (progressive doses of aerosolized capsaicin while behaviorally suppressing cough; n = 11) or a sham treatment (repeated exposure to aerosolized saline; n = 9). The Leicester Cough Questionnaire (LCQ) was the primary outcome measure. Perceived cough severity with a visual analogue scale and cough challenge testing (for measuring cough-reflex sensitivity) were secondary outcome measures. Data were analyzed with mixed effects linear regression and follow-up contrasts. Results Results on all measures favored CDT. Excluding one sham participant, whose baseline LCQ scores were deemed unreliable, mean change in LCQ at 3-weeks post treatment was 6.35 and 2.17 in the CDT and sham groups, respectively. There was moderate to strong evidence of a greater improvement in the CDT group in total LCQ score (p = .058) and LCQ Psychological domain (p = .026) and Physical domain (p = .045) scores. Strong evidence was found for a greater reduction in urge-to-cough during CCT in the CDT group (p = .037) and marginal for a reduction in the capsaicin cough-reflex sensitivity (p = .094). There was weak evidence of a greater reduction in cough severity in the CDT group (p = .103). Discussion Although the study is limited due to the small sample size, the data provide additional evidence supporting further research on CDT. CDT resulted in a greater change in the primary efficacy measure (LCQ) than both pharmaceutical and behavioral treatments currently found in the literature. Trial Registration This trial (NCT05226299) was registered on Clinicaltrials.gov on 07/02/2022.

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“…In the present large, community-based sample, neither age nor gender affected the LCQ scores suggesting that the same grading can be used in all adult age groups and in both genders. Accordingly, age was not associated with LCQ scores in the healthy subjects investigated by Reynolds et al [4]. However, they could not assess the effect of gender due to a small number of males in their sample.…”

mentioning

confidence: 79%