Normative values of retinal vessel oximetry in healthy children against adults

Waizel, Maria della Volpe; Türksever, Cengiz; Todorova, Margarita G.

doi:10.1111/aos.13726

Cited by 11 publications

(11 citation statements)

References 48 publications

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“…; Todorova et al. ; Waizel et al ). Since oxygen is an important metabolite for the maintenance of a proper visual function, RO allows for a deeper insight into the metabolic alterations of the retina (Stefánsson et al.…”

Section: Introductionmentioning

confidence: 99%

Influence of cataract light scatters on retinal vessel oxygen saturation

Waizel

Türksever

Todorova

2019

Acta Ophthalmologica

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Background: The aim of our study was to compare metabolic (oxygen saturation; %) and anatomical parameters (retinal vessel diameter; lm) of retinal vessel oximetry (RO) in patients with cataract formation against those of healthy controls with clear lenses. Methods: A total of 96 eyes of 62 subjects were examined: 51 eyes from 33 cataract patients (mean age: 64.8y) were compared to 45 eyes from 29 controls with clear lenses (mean age: 61.5y). RO was performed with the oxygen saturation measurement tool from the RVA (IMEDOS Systems UG). The oxygen saturation in all major peripapillary retinal arterioles (A-SO 2 ) and venules (V-SO 2 ) was measured, and their difference (A-V SO 2 ) was calculated. In addition, the corresponding diameter in retinal arterioles (D-A) and venules (D-V) was evaluated. Cataract formation was graded according to the Lens Opacities Classification System III (LOCS III). Oximetry data were compared with the grade of cataract formation within both groups. For statistical evaluation, ANOVAbased linear mixed-effects models were calculated (SPSS â , pairwise comparisons: Bonferroni-corrected; p < 0.05). Results: Cataract eyes showed significantly lower A-SO 2 and A-V SO 2 values (mean AE SD 92.52 AE 9.80% and 28.56 AE 9.80%), when compared to healthy controls (95.47 AE 4.48% and 34.8 AE 7.08%; p = 0.046 and p = 0.001). Within the cataract group, cortical opacities showed significant interactions with the A-SO 2 , V-SO 2 and the A-V SO 2 parameters (p = 0.027; p = 0.002; and p = 0.026, respectively). Conclusions: These data indicate that the cataract-induced light scatter influences optical retinal oxygen measurements. Cortical opacities showed the highest influence on RO measurement when compared to nuclear opacification, nuclear colour and posterior cataract formation.

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Section: Introductionmentioning

confidence: 99%

Influence of cataract light scatters on retinal vessel oxygen saturation

Waizel

Türksever

Todorova

2019

Acta Ophthalmologica

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“…One other limitation of the study is that both subgroups presented a smaller sample size of 16, respectively 26 eyes, with slightly younger cohorts. Even if the age differences were not statistically significant to other subgroups, it is already known that the vascular diameter measurements in very young children can be increased when compared to older children (Waizel et al 2018b). Another limitation of our study is the missing objective criteria for a distinct classification of the progression for each single patient within the IRD group.…”

Section: Discussionmentioning

confidence: 87%

“…So far, RO parameters have been measured in healthy Caucasian children aged between 5 and 18 years (Waizel et al 2018b), in predominantly myopic Chinese children and adolescents (Liu et al 2017; Liu et al 2019) and Caucasian infants aged around 16 days (Vehmeijer et al 2016). These studies represent a good basis for further investigations with diseased children and those with a positive family history for IRDs.…”

Section: Introductionmentioning

confidence: 99%

Retinal vessel oximetry in children with inherited retinal diseases

Waizel

Scholl

Valmaggia

et al. 2020

Acta Ophthalmologica

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Background Retinal vessel oximetry (RO) has been used to show altered metabolic function in patients with inherited retinal diseases (IRDs). The aim of this study was to investigate RO parameters of children with IRDs and presumed IRD carriers (pIRDc) and to compare them to controls. Methods In this cross‐sectional cohort study, 142 eyes from 71 Caucasian subjects were included: 40 eyes with IRDs, 26 eyes with pIRDc and 76 control eyes. The oxygen saturation was measured with the Retinal Vessel Analyser (IMEDOS Systems UG, Jena, Germany). Mean oxygen saturations in the peripapillary retinal arterioles (A‐SO2; %) and venules (V‐SO2; %) were estimated, and their difference (A‐V SO2; %) was calculated. In addition, we evaluated the mean diameter in all major retinal arterioles (D‐A; μm) and venules (D‐V; μm). anova‐based linear mixed‐effects models were calculated with SPSS®. Results In general, children suffering from IRDs differed from controls when the A‐SO2 and A‐V SO2 were taken into account: both the A‐SO2 and the A‐V SO2 were significantly increased (p = 0.012). In subgroup analyses, children suffering from rod–cone dystrophy (RCD) presented an A‐SO2 increase (99.12 ± 8.24%) when compared to controls (91.33 ± 10.34%, p = 0.014) and pIRDc (92.37 ± 6.57%, p = 0.065). For V‐SO2 significant changes in RCD (67.42 ± 9.19%) were found in comparison with controls (58.24 ± 11.74%, p < 0.041), pIRDc (56.67 ± 7.16%, p = 0.007), cone–rod dystrophies (CRD, 52.17 ± 5.32%, p < 0.001) and inherited macular dystrophies (IMD, 55.74 ± 6.96%, p = 0.004), In addition, A‐V SO2 was decreased in RCD (31.69 ± 3.92%) when measured against CRD (41.9 ± 8.87%, p = 0.017) or IMD (39.52 ± 8.95%, p = 0.059). Conclusion In general, we found that children with IRDs presented early metabolic changes. Within IRDs, children with RCD showed more affected metabolic changes. Thus, RO may support early screening to rule out IRDs in children, and more precisely may help to differentiate those suffering from RCD.

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“…Some possible explanations could be the decreased vessel dispensability, the ongoing vascular structural remodeling and also changes in viscoelastic properties occurring with ageing [ 83 ]. All of these are probably leading to metabolic changes throughout their lifetime [ 84 ].…”

Section: Discussionmentioning

confidence: 99%

The Presence of Hyperreflective Foci Reflects Vascular, Morphologic and Metabolic Alterations in Retinitis Pigmentosa

Diem

Türksever

Todorova

2022

Genes

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Background: The presence of hyperreflective foci (HRF) in retinitis pigmentosa (RP) is a potentially new finding. We investigated the presence of HRF in SD-OCT images in eyes with RP and its relation to vascular, morphologic and metabolic findings in RP. Methods: The study was performed on 42 RP patients and 24 controls. Using SD-OCT, we calculated the amount of HRF within the entire retina (HRF-ER) and the outer nuclear layer (HRF-ONL). Retinal vessel diameters (μm) and oxygen saturation (%) values were measured using Oxymap T1. We evaluated the mean diameter in retinal arterioles (D-A) and venules (D-V), the corresponding oxygen saturation values (A-SO2, V-SO2) and the oxygen saturation difference (A-V SO2). Results: RP differed from controls by HRF-ER, HRF-ON and EZ-length (p < 0.001). D-A and D-V were narrower and A-SO2 and V-SO2 were higher in RP (p ≤ 0.001). Within RP, significant interactions were found between the HRF-ER* group and: BCVA, EZ length, D-A, A-SO2 and A-V SO2 (p ≤ 0.018). The HRF-ONL* group interactions were significant for: BCVA, EZ length, D-A, A-SO2 and A-V SO2 (p ≤ 0.014). Conclusion: The present study highlights the presence of HRF to reflect the vascular, morphologic and metabolic alterations in RP. These biomarkers seem to be associated with remodeling and apoptosis that occur with the progression of degeneration.

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Normative values of retinal vessel oximetry in healthy children against adults

Abstract: These data indicate that the retinal oxygen metabolism changes throughout lifetime. Therefore, normative data for different age groups are mandatory.

Cited by 11 publications

References 48 publications

Influence of cataract light scatters on retinal vessel oxygen saturation

Influence of cataract light scatters on retinal vessel oxygen saturation

Retinal vessel oximetry in children with inherited retinal diseases

The Presence of Hyperreflective Foci Reflects Vascular, Morphologic and Metabolic Alterations in Retinitis Pigmentosa

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