Normative Values of The Retinal Macular Thickness in a Middle Eastern Population.

Abstract

Background: Since the normative value of the retinal macular thickness is undocumented in the Middle East, the aim of this work is to assess the normative values of the macular thickness in healthy eyes in a Middle Eastern population and its relationship with age, sex, and laterality. Methods:116 individuals were randomly selected from volunteers visiting the Jordan University Hospital in Amman, Jordan. Measurements were obtained using the Fourier domain optical coherence tomography (OCT). Multivariate regression models were developed to obtain predicted normative values with adjustment to candidate variables. In addition, the effect of age, sex and laterality were evaluated. Results: The average central fovea macular thickness was 229.5 (±30.85) um. The quadratic value of the retinal macular thickness decreased from the superior value of 299.71 (±23.67) um (P=.001)to the inferior value of 296.46 (±28.85) um(P=.001) and a nasal figure of 93.63 (±26.86) um(P=.001). The temporal area has the thinnest value of 293.43 (±30.78) um( P=0.001). Central thickness was higher in males with a mean variation of 11.67 um (95% CI: 2.41 to 20.93) (p= 0.003). The thickness was highest within 3mm diameter from the center and decreased towards the periphery Eye sidedness didn’t contribute to variability of the macular thickness. Furthermore, we found a significant difference between age and central macular thickness (p= 0.001)as age was a positive predictor for macular thickness Conclusion: Our set of predicted normative data may be used to interpret measurement of the macular thickness in Middle Eastern population. The average fovea macular thickness among Jordanians is consistent with previously reported values. Normative values from additional Middle Eastern populations are required to appraise our module.