2020
DOI: 10.1002/jbm4.10391
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Normocalcemic Hyperparathyroidism: A Heterogeneous Disorder Often Misdiagnosed?

Abstract: Normocalcemic primary hyperparathyroidism (NHPT) was first described over 10 years ago, but uncertainties still remain about its definition, prevalence, and rates of complications. As a result, consensus management guidelines for this condition have not yet been published. Several hypotheses have been proposed for the pathophysiology of NHPT, but it may be a heterogeneous disorder with multiple causes, rather than a single etiology that explains this biochemical phenotype. A common clinical concern is whether … Show more

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Cited by 36 publications
(37 citation statements)
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“…Since sCa in PHPT patients often fluctuates, single measurement of sCa with upper-normal range can result in the misdiagnosis of NPHPT. 28 …”
Section: Discussionmentioning
confidence: 99%
“…Since sCa in PHPT patients often fluctuates, single measurement of sCa with upper-normal range can result in the misdiagnosis of NPHPT. 28 …”
Section: Discussionmentioning
confidence: 99%
“…Consequently, normocalcemic PHPT represents a diagnosis of exclusion and can only be considered following a careful evaluation of causes of secondary hyperparathyroidism (Fig. 2) (30).…”
Section: Q2 What Is Normocalcemic Phpt?mentioning
confidence: 99%
“…Further studies investigating alterations in PTH following vitamin D supplementation in vitamin D-deficient stone-forming populations would be beneficial [23]. Normocalcaemic hyperparathyroidism may be linked to renal stone disease and therefore, in individuals with recurrent nephrolithiasis or at high risk of future stone disease, serum PTH measurement may be a useful component of a full metabolic assessment [24].…”
Section: Discussionmentioning
confidence: 99%