Normocalcemic primary hyperparathyroidism: A newly emerging disease needing therapeutic intervention

Díaz-Soto, Gonzalo; Julián, María Teresa; Puig-Domingo, Manel

doi:10.14310/horm.2002.1370

Cited by 20 publications

(22 citation statements)

References 40 publications

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“…Also, there was no correlation with vitamin D in both the patients' group and the control group. Although studies have shown that vitamin D levels below 30 ng/mL could lead to an increase in PTH, this did not happen in the present study [19,49,50].…”

Section: Discussioncontrasting

confidence: 80%

Vitamin D in Hashimoto’s thyroiditis and its relationship with thyroid function and inflammatory status

et al. 2018

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Several studies have shown the correlation between vitamin D [25(OH)D] deficiency and thyroid autoimmunity and reducing of thyroid autoantibodies in patients with normal levels of vitamin D combining with thyroid hormone replacement. However, other authors not agree with this association. It is still unclear whether the low 25(OH)D levels are the result of HT disease or a part of its cause. We studied 88 patients with HT regarding vitamin D status and thyroid autoimmunity markers as well as the relationship with cytokines produced by Th1, Th2, and Th17 cells compared with a control group of 71 euthyroid healthy subjects. The present study demonstrated that vitamin D concentrations were similar in patients HT and the control group. The reduction of free T4 levels was a predictor of vitamin D insufficiency for Hashimoto's thyroiditis, but not for the control group. Lower concentrations of TNF-α was a predictor of lower levels of vitamin D. Differences in the association between HT and vitamin D insufficiency remain unresolved in the literature. The thyroid hormone status would play a role in the maintenance of vitamin D sufficiency, and its immunomodulatory role would influence the presence of autoimmune thyroid disease. The positive correlation between free T4 and vitamin D concentrations suggests that adequate levothyroxine replacement in HT would be an essential factor in maintaining vitamin D at sufficient levels.

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Section: Discussioncontrasting

confidence: 80%

Vitamin D in Hashimoto’s thyroiditis and its relationship with thyroid function and inflammatory status

et al. 2018

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“…Elevated PTH accompanies 20-45% of patients with vitamin D deficiency (14). Normocalcemic hyperparathyroidism (ncHPT) is constantly normal serum calcium levels and elevated PTH levels without any secondary cause that will lead to elevation in PTH levels (15,16). In order to establish the diagnosis of ncHPT both total and ionized calcium levels should be within normal limits.…”

Section: Discussionmentioning

confidence: 99%

Examination of the Etiologic Causes in Patients Presenting with Elevated Parathormone

Kırhan¹,

Eren²

2019

Tod

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Parathyroid hormone (PTH) levels are elevated in the blood due to various reasons and named as primary or secondary hyperparathyroidism. There is no any study that investigated the etiology of elevated PTH. Materials and Methods: The study included 137 patients who had elevated PTH, which was detected in blood tests that were performed due to any reason, during 1-year period. Results: Of all patients 118 (86.1%) were female and 19 (13.9%) were male. Vitamin D deficiency was found in 88 (64.2%), primary hyperparathyroidism (PHPT) in 38 (27.7%), familial hypocalciuric hypercalcemia (FHH) in 8 (5.8%), and chronic renal failure (CRF) in 3 (2.2%) patients. Conclusion: Vitamin D deficiency is a common disorder in general population, and occasionally coexisted with increased PTH level. Therefore, vitamin D deficiency should be kept in mind when PTH studied as a first test and is found to be high. The other reason such as PHPT, FHH and CRF must be also investigated.

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“…This for practical clinical purposes means that the albumin corrected serum calcium is in the normal range. It has been suggested that both total and serum ionized calcium should be in the normal range [12]. However; reliability of ionized calcium in clinical laboratories may be questionable.…”

Section: Discussionmentioning

confidence: 99%