Journalism is thought by many scholars to have an immense effect in controlling corruption. However, they do not know the conditions under which its performance brings about positive results in some countries while serving to protect corrupt policies and corrupt policy makers in some other countries. Journalism combats corruption through its content, freedom, structure, independence, ownership patterns, diversity, ethics, and professionalism, all of which demonstrate significant variations across cultures and nations. As a social institution, journalism does not work in a vacuum. Its impact is heavily determined by a variety of interacting variables characterizing both the nation system and international system in which it operates. The purpose of this chapter is to develop a hierarchical universal theory of journalism-corruption determinants. The theory perceives corruption act as an outcome of a continuous interaction between five hierarchical levels. They are: (1) journalistic level, (2) economic level, (3) political level, (4) cultural level, and (5) international system level. In general, each level has many sublevels interacting with each other to bring about an effect on corruption that could be negative or positive, minor or major, and finally in one domain or multiple domains. The suggested theory is based on a critically assessment revision of the current literature in several disciplines. The ultimate purpose is to create linkages capable to explain corruption, predict it, direct the future studies, and finally contribute to reducing it.