Nornostocine congeners as potential anticancer drugs: An overview

Sahoo, Chita Ranjan; Paidesetty, Sudhir Kumar; Padhy, Rabindra N.

doi:10.1002/ddr.21577

Cited by 18 publications

(3 citation statements)

References 28 publications

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“…1 Some 1,2,4-triazine derivatives containing fused rings of other heterocycles are used as antibiotics (toxoflavin, fervenulin, and reumycin), 2 effective antiviral drugs (triazavirin 3 and remdesivir 4 ), and have been identified as bacterial pigments (nostocine, pseudoiodinin, and fluviols) that also show antitumor activity against certain cell lines. 5 …”

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confidence: 99%

Synthesis and antiproliferative activity characterization of new imidazothiazolotriazine oxindolylidene derivatives containing various substituents in the oxindole ring

Izmest’ev

Кравченко

Газиева

2022

Chem Heterocycl Comp

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Condensation of 1,3-diethyltetrahydroimidazo[4,5- е ]thiazolo[3,2- b ][1,2,4]triazine-2,7-dione with isatins followed by framework rearrangement in the thiazolotriazine moiety was used to synthesize two new series of oxindolylidenetetrahydroimidazo[4,5- е ]thiazolo- [3,2- b ][1,2,4]triazine-2,7-diones and oxindolylidenetetrahydroimidazo[4,5- е ]thiazolo[2,3- c ][1,2,4]triazine-2,8-diones containing various substituents in the oxindole moiety. The obtained compounds were tested for antiproliferative activity. The greatest activity was observed in the case of 1-alkyl-7-methyloxindolylidene derivatives of imidazo[4,5- е ]thiazolo[2,3- c ]triazine, which not only inhibited the growth of more than half of the studied cell lines, but also caused cell death in the SF-539 cell line (central nervous system cancer, mean growth percent –7.82%) and MDA-MB-435 (melanoma, –30.97 and –13.64%). Supplementary Information The online version contains supplementary material available at 10.1007/s10593-022-03125-3.

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confidence: 99%

Synthesis and antiproliferative activity characterization of new imidazothiazolotriazine oxindolylidene derivatives containing various substituents in the oxindole ring

Izmest’ev

Кравченко

Газиева

2022

Chem Heterocycl Comp

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“…Concomitantly, most of the synthesized congeners are not qualified clinically. There is a prerequisite of the semi‐synthetic derived new potent candidate against the dreadful disease, cancer (Sahoo et al, 2019a, 2019b).…”

Section: Biological Actions Of Thymol Derivativesmentioning

confidence: 99%

The recent development of thymol derivative as a promising pharmacological scaffold

Sahoo

Paidesetty

Padhy

2021

Drug Development Research

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Thymol (a phenol ring bearing active phytoconstituent) is a privileged scaffold, which is diversified in natural sources. This scaffold acts as an obligatory template for scheming and arriving at designing some newer drug‐molecules with potential biological activities. In the pharmacological perspective, the promising active sites of the scaffold are the positions C‐1, C‐4, and C‐6 of thymol that would be accountable for developing potent drug candidates. This review aims to explore the various synthetic routes and the structural‐activity relationship of thymol scaffold with suitable active pharmacophore sites.

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“…Those scaffold linked with substituted sulfonamide moiety at C-5 position, which have shown greater inhibition with tyrosine kinase and urease. 2,3 Schiff based compounds are versatile building blockers and synthetic precursors for various organic heterocyclic compounds, which have azomethine-CH=N-linked in their structures, with manifestation of a broad range of biological activities viz., antibacterial, antifungal, anticancer, antiviral properties and a few more. 4 Analogues of the phytocompound, isatin conjugated with sulfonamides have significant activities on tumor associated carbonic anhydrase.…”

Section: Introductionmentioning

confidence: 99%

Nostocine A Derivatives as Human DNA Topoisomerase II-alpha Inhibitor

Sahoo¹,

Paidesetty²,

Padhy³

2020

IJPER

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Introduction: Due to heavy morbidity and mortality from cancer, the designing of newer drugable molecules against breast cancer is the call of day. As, Schiff-base sulfonamides have been widely used in tumor treatments. Methods: Nostocine-sulfonamide (NS) Schiff-base molecules were designed with tools of bioinformatics against the target enzyme, human topoisomerase II-alpha (topo IIa) against breast cancer. The designed NS conjugates were assessed by RO5, ADMET and molecular docking. Results: Herein, these analogues, NS-20b (Nostocine A-sulfaphenazole), 12a (Nostocine A-sulfisoxazole) and 16b (Nostocine A-sulfamethazineare) are N-heteroaryl substituted sulfonamide moieties linked with pyrazolo[4,3-e][1,2,4]triazine of Nostocine A. Conclusion: These derivatives would act as potent inhibitors of topo IIa for breast cancer.

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Nornostocine congeners as potential anticancer drugs: An overview

Cited by 18 publications

References 28 publications

Synthesis and antiproliferative activity characterization of new imidazothiazolotriazine oxindolylidene derivatives containing various substituents in the oxindole ring

Synthesis and antiproliferative activity characterization of new imidazothiazolotriazine oxindolylidene derivatives containing various substituents in the oxindole ring

The recent development of thymol derivative as a promising pharmacological scaffold

Nostocine A Derivatives as Human DNA Topoisomerase II-alpha Inhibitor

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