Nöromiyelitis optika: Olgu sunumu

Gürgen, Nurgül; Yalcin, Destina; Gözükızıl, Salim Taner; Polisci, Deniz

doi:10.5350/semb.20150806062945

Cited by 1 publication

(11 citation statements)

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“…NMOSD is previously known as Devic's syndrome and is a progressive inflammatory demyelinating autoimmune condition that is characterized by the presence of autoantibodies, particularly IgG 1 , against the water channel protein AQP‐4 1–3 . Initially, NMOSD was classified as a subtype of multiple sclerosis due to its clinical presentations 3,5,7,13 .…”

Section: Discussionmentioning

confidence: 99%

“…Initially, NMOSD was classified as a subtype of multiple sclerosis due to its clinical presentations 3,5,7,13 . The central nervous system is mostly affected and usually presents with features suggestive of chronic inflammation leading to demyelination of neurons due to invasion and destruction of astrocytes by anti‐NMO antibodies 2,3,11 . The course of NMOSD is progressive over weeks to years as compared to other demyelinating diseases and can be monophasic or relapsing–remitting patterns 4,7 .…”

Section: Discussionmentioning

confidence: 99%

“…6,7,11 Besides, few patients with NMOSD may be seronegative accounting for 10 to 20% but still present with other core clinical characteristics. 2,24,25 About 20%-30% of NMOSD cases have a variety of symptoms that resemble those of other autoimmune disorders. 12,23 Other autoimmune diseases that have been reported to coexist with NMOSD include myasthenia gravis, thyroid disease, ankylosing spondylitis, pernicious anemia, ulcerative colitis, systemic lupus erythematosus, and thrombotic thrombocytopenic purpura.…”

Section: Discussionmentioning

confidence: 99%

“…[26][27][28] The development of autoantibodies as a result of complement pathways, activation of interleukins, particularly IL-6, and molecular mimicry of autoreactive B cells represent the hallmarks of the co-occurrence of disease. 2,27,28 NMOSD occurs as a result of these autoantibodies invading and destroying the nervous system's astrocytes. 23,29 In this instance, an African female in her early 40s qualified criteria for NMOSD due to a history of progressive loss of vision, transverse myelitis, and positive autoantibody against AQP-4.…”

Section: Discussionmentioning

confidence: 99%

“…Neuromyelitis optica spectrum disorder is previously known as Devic's syndrome 1–3 . NMOSD is a progressive demyelinating autoimmune condition resulting from immunoglobulins subtype G1 produced against water channel protein aquaporin (AQP‐4), which usually affects the cranial nerves, spinal cord, and central nervous system 3–5 .…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Neuromyelitis optica spectrum disorder co‐existing with antiphospholipid syndrome: A case report

Edwin,

Msagati,

Komanya

et al. 2024

Clinical Case Reports

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Key clinical messageNeuromyelitis optica spectrum disorder is an autoimmune disease, rarely presents with antiphospholipid syndrome. Diagnosis and management of NMOSD are challenging in the background of diverse presentations, especially in resource‐limited settings.AbstractNeuromyelitis optica spectrum disorder (NMOSD) is a progressive demyelinating autoimmune condition resulting from the autoantibodies produced against aquaporin‐4 (AQP‐4) proteins which are widely distributed in astrocytes in the nervous system. In the setting of NMOSD, it is very crucial to consider other autoimmune diseases as differential diagnoses or co‐occurrences due to the diversity of symptoms. NMOSD co‐exists with other autoimmune diseases such as myasthenia gravis, thyroid disease, ankylosing spondylitis, pernicious anemia, thrombotic thrombocytopenic purpura, ulcerative colitis, and systemic lupus erythematosus. Few cases of antiphospholipid syndrome co‐existing with NMOSD have been reported. In resource‐limited settings, the published data are scarce, and therefore, autoimmune diseases are poorly studied. Therefore, late diagnosis and delayed treatment initiation pose long‐term sequelae and hence poor prognosis. Here, we present a case of an African woman in her early 40s presenting with bilateral progressive loss of vision, transverse myelitis, extensive longitudinal hyperintense T2 cervical lesion, and AQP‐4 autoantibody keeping with NMOSD. The co‐existence of antiphospholipid syndrome, in this case, was supported by a history of recurrent pregnancy loss and positive antiphospholipid antibodies. This case underscores the importance of individualized‐based medicine, especially in resource‐limited settings.

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Section: Discussionmentioning

confidence: 99%