Norovirus and Rotavirus infection in children aged less than five years in a paediatric hospital, Havana, Cuba

Ribas, María de los Ángeles; Castaño, Yuselis; Martínez, Marlon Daniel; Tejero, Yahisel; Cordero, Yanislet

doi:10.1016/j.bjid.2014.10.002

Cited by 4 publications

(3 citation statements)

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“…[24,25] Children aged <5 years show the highest rates of ADD and ARI. [26] The main causes of ADD in Cuba are rotaviruses and noroviruses; [27] for ARI the main cause is rhinovirus, and human sincitial respiratory virus in children aged <1 year. [28] The norovirus as a cause of infl ammation was described in a longitudinal study in infected adults.…”

Section: Discussionmentioning

confidence: 99%

Influence of Inflammation on Assessing Iron-Deficiency Anemia in Cuban Preschool Children

Pita-Rodríguez¹,

Chávez-Chong²,

Lambert-Lamazares³

et al. 2021

MEDICC Review

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INTRODUCTION Anemia is a public health problem worldwide and is most prevalent in preschool children, for whom it is the most frequent cause of nutritional defi cits. In turn, iron defi ciency is the main cause of anemia, affecting 43% of children globally. Previous studies in Cuba show rates of iron defi ciency in preschool children between 38.6% and 57.6%, higher in infants (71.2% to 81.1%). WHO recommends using serum ferritin as an indicator of iron defi ciency accompanied by acute (C-reactive protein) and chronic (α1-acid glycoprotein) infl ammation biomarkers. OBJECTIVE Assess how infl ammation affects measuring and reporting of iron-defi ciency anemia rates in Cuban preschool children.METHODS Data were obtained from serum samples contained in the National Anemia and Iron Defi ciency Survey, and included presumably healthy preschool Cuban children (aged 6-59 months). Serum samples were collected from 1375 children from randomly selected provinces in 4 regions of the country from 2014 through 2018. We examined the association between ferritin and two infl ammatory biomarkers: C-reactive protein and α1-acid glycoprotein. Individual infl ammation-adjusted ferritin concentrations were calculated using four approaches: 1) a higher ferritin cut-off point (<30 g/L); 2) exclusion of subjects showing infl ammation (C-reactive protein >5 mg/L or α1-acid glycoprotein >1 g/L); 3) mathematical correction factor based on C-reactive protein or α1-acid glycoprotein; and 4) correction by regression with the method proposed by the Biomarkers Refl ecting Infl ammation and Nutritional Determinants of Anemia Group. We estimated confi dence intervals of differences between unadjusted prevalence and prevalence adjusted for infl ammation by each method. RESULTSThe proportion of children with infl ammation according to C-reactive protein concentrations >5 mg/L was lower (11.1%, 153/1375) than the proportion measured according to the concentrations of α1-acid glycoprotein, at >1 g/L (30.8%, 424/1375). The percentage of children with high concentrations of at least one of the aforementioned biomarkers was 32.7% (450/1375). Thus, each correction method increased the observed prevalence of iron defi ciency compared to unadjusted estimates (23%, 316/1375). This increase was more pronounced when using the internal regression correction method (based only on C-reactive protein) or the method based on a higher cut-off point. Adjustment using all four methods changed estimated iron defi ciency prevalence, increasing it from 0.1% to 8.8%, compared to unadjusted values. CONCLUSION One-third of preschool children had biomarkers indicating elevated infl ammation levels. Without adjusting for infl ammation, iron defi ciency prevalence was underestimated. The signifi cant disparity between unadjusted and infl ammationadjusted ferritin when using some approaches highlights the importance of selecting the right approach for accurate, corrected measurement. The internal regression correction approach is appropriate for epidemiological studies because...

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Section: Discussionmentioning

confidence: 99%

Influence of Inflammation on Assessing Iron-Deficiency Anemia in Cuban Preschool Children

Pita-Rodríguez¹,

Chávez-Chong²,

Lambert-Lamazares³

et al. 2021

MEDICC Review

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“…Food‐borne diseases cost the region millions of dollars in health care and has adverse implications on the tourism industry. Based on a handful of peer‐reviewed articles, and some media reports, norovirus, followed by rotavirus, appear to be the most important viral enteropathogens in the Greater and Lesser Antilles, although the impact of these viruses to the region remains to be properly elucidated (Esona et al., 2015; Indar, 2012; Indar et al., 2015; Ingram et al., 2013; Leshem et al., 2016; Katz et al., 2019; Ribas et al., 2015a, b). Both noroviruses and rotaviruses have been reported in livestock and shown to have zoonotic potential (Ghosh & Kobayashi, 2011; Villabruna et al., 2019).…”

Section: Discussionmentioning

confidence: 99%

A comprehensive review of viruses in terrestrial animals from the Caribbean islands of Greater and Lesser Antilles

Gainor

Ghosh

2022

Transbounding Emerging Dis

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Viruses pose a major threat to animal health worldwide, causing significant mortalities and morbidities in livestock, companion animals and wildlife, with adverse implications on human health, livelihoods, food safety and security, regional/national economies and biodiversity. The Greater and Lesser Antilles consist of a cluster of islands between the North and South Americas and is habitat to a wide variety of animal species. This review is the first to put together decades of information on different viruses circulating in companion animals, livestock and wildlife from the Caribbean islands of Greater and Lesser Antilles. Although animal viral diseases have been documented in the Caribbean region since the 1940s, we found that studies on different animal viruses are limited, inconsistent and scattered. Furthermore, a significant number of the reports were based on serological assays, yielding preliminary data. The available information was assessed to identify knowledge gaps and limitations, and accordingly, recommendations were made, with the overall goal to improve animal health and production, and combat zoonoses in the region.

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“…Desde a sua descoberta, os Norovírus são associados a surtos de gastroenterites não bacterianas em todo o mundo; entre os casos mais recentes estão infecção por Norovírus e Rotavírus em crianças com menos de cinco anos em um hospital pediátrico, Havana, Cuba (RIBAS et al, 2015).…”

Section: Epidemiologia Das Noroviroses No Mundo E No Brasilunclassified

Epidemiologia da Norovirose e Estudo do Papel do Cão como Reservatório para este Agente Zoonotico

Vieira

Lima

Santos

et al. 2019

UNIC

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Os norovírus foram os primeiros agentes virais ligados a doenças gastrointestinais em humanos. Por muito tempo, foram considerados como causa secundária de gastroenterite, após o rotavírus. O desenvolvimento de técnicas moleculares favoreceu dados mais claros sobre o impacto epidemiológico dos norovírus, que são atualmente reconhecidos como principal causa de surtos de gastroenterite não bacteriana esporádica em crianças e adultos. Em análise da diversidade genética e recombinação dos norovírus sabe-se que os mesmos estão presentes em várias espécies animais, incluindo os cães, o que denota na possível exposição dos seres humanos a estas novas cepas recém-descobertas. Devido à intensa relação social atualmente observada entre humanos e animais de estimação, sugerem-se novas investigações sobre o potencial zoonótico deste norovírus. O método de pesquisa utilizado neste trabalho foi uma revisão de literatura, que teve como objetivo revisar toda literatura atual sobre a epidemiologia e relevância do cão como potencial reservatório para este agente. Ainda são poucos os relatos sobre a presença do norovírus em cães, que podem apresentar um potencial de transferência zoonótica, porém devido à sua maior proximidade com os seres humanos na atualidade, considera-se a importância de novos estudos para avaliar o papel do cão como reservatório do norovírus, em especial no Brasil, pela inexistência de relatos até o presente momento. Palavras-chave: Cães. Gastroenterite não Bacteriana. Risco Zoonótico. AbstractNoroviruses were the first viral agents linked to gastrointestinal diseases in humans. For a long time, they were considered as secondary cause of gastroenteritis after rotavirus. The development of molecular techniques has favored clearer data on the epidemiological impact of noroviruses, which are currently recognized as the main cause of outbreaks of sporadic non-bacterial gastroenteritis in children and adults. In analyzing the genetic diversity and recombination of noroviruses it is known that they are present in several animal species, including dogs, which denotes the possible exposure of humans to these newly discovered strains. Due to the intense social relationship currently observed between humans and pets, further research on the zoonotic potential of this norovirus is suggested. The research method used is a review of the literature, which aimed to review all current literature on the epidemiology and relevance of the dog as potential reservoir for this agent. There are still few reports on the presence of norovirus in dogs, which may present a potential for zoonotic transfer, but due to its greater proximity to humans nowadays, the importance of new studies to evaluate the role of the dog as norovirus reservoir, especially in Brazil, due to the lack of reports to date. Keywords: Dog. Nonbacterial Gastroenteritis. Zoonotic Potential.

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Norovirus and Rotavirus infection in children aged less than five years in a paediatric hospital, Havana, Cuba

Cited by 4 publications

References 4 publications

Influence of Inflammation on Assessing Iron-Deficiency Anemia in Cuban Preschool Children

Influence of Inflammation on Assessing Iron-Deficiency Anemia in Cuban Preschool Children

A comprehensive review of viruses in terrestrial animals from the Caribbean islands of Greater and Lesser Antilles

Epidemiologia da Norovirose e Estudo do Papel do Cão como Reservatório para este Agente Zoonotico

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