North American Artemisia species from the subgenus Tridentatae (Sagebrush): A phytochemical, botanical and pharmacological review

Turi, Christina E.; Shipley, Paul R.; Murch, Susan J.

doi:10.1016/j.phytochem.2013.11.016

Cited by 44 publications

(30 citation statements)

References 90 publications

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“…The putative metabolite identifications of A. maderaspatana indicate more sesquiterpenes than monoterpenes contrary to A. tridentate Nutt. of North American origin (Turi et al, 2014). This may be due to the fact that In Artemisia species, diverse monoterpene and sesquiterpene compounds are produced in the glandular trichomes present on leaf surfaces (Ruhland et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

Chemical composition and acetylcholinesterase inhibitory activity ofArtemisia maderaspatanaessential oil

Jyotshna¹,

Srivastava²,

Singh³

et al. 2015

Pharmaceutical Biology

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Context: To date, there are no reports to validate the Indian traditional and folklore claims of Artemisia maderaspatana L. (syn. Grangea maderaspatana L.) (Asteraceae) for the treatment of Alzheimer's disease. Objective: The present study characterizes the volatile components (non-polar compounds) of A. maderaspatana and evaluates its acetylcholinesterase inhibition potential. Materials and methods: The essential oils (yield 0.06% v/w) were obtained from fresh aerial part of A. maderaspatana. The characterization of volatile components (non-polar compounds) was performed by GC-MS data and with those of reference compounds compiled in the spectral library of in-house database. The in vitro acetylcholinesterase (AChE) inhibition of the volatile organic constituents (VOC's) of A. maderaspatana aerial part was evaluated in varying concentration ranges (0.70-44.75 mg/mL) with Ellman's method. Results: The major components were a-humulene (46.3%), b-caryophyllene (9.3%), a-copaene (8.2%), b-myrcene (4.3%), Z(E)-a-farnesene (3.7%), and calarene (3.5%). Chemical variability among other Artemisia spp. from different climatic regions of India and countries namely Iran and France was observed. The experimental results showed that diverse volatile organic constituents of A. maderaspatana have significant acetylcholinesterase inhibitory activity (an IC 50 value of 31.33 ± 1.03 mg/mL). This is the first report on the inhibition of acetylcholinesterase properties of essential oil of A. maderaspatana obtained from fresh aerial part. Conclusions: The present results indicate that essential oil of A. maderaspatana isolated from the northern region of India could inhibit AChE moderately. Therefore, the possibility of novel AChE inhibitors might exist in VOCs of this plant.

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Section: Resultsmentioning

confidence: 99%

Chemical composition and acetylcholinesterase inhibitory activity ofArtemisia maderaspatanaessential oil

Jyotshna¹,

Srivastava²,

Singh³

et al. 2015

Pharmaceutical Biology

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“…Compounds exhibiting exponential or linear behavior (R 2 > 0.75) in response to galanthamine treatments were then subjected to putative identification using Metabosearch http:// omics.georgetown.edu/MetaboSearch.html, Plant Metabolic Pathway Database http://www.plantcyc.org/, and phytochemical information gathered from a comprehensive review on North American Sagebrush. 9 Putative identifications (± 0.02 daltons) were performed using a previously published protocol.…”

Section: 65mentioning

confidence: 99%

“…8 A total of 220 phytochemicals have been described in A. tridentata and related species in the Tridentatae. 9 Recently, the neurologically active compounds melatonin (MEL), serotonin (5HT), and acetylcholine (Ach) were identified and quantified in axenic cultures of A. tridentata. 10 MEL and 5HT have previously been identified and quantified in axenic culture of several plant species.…”

Section: Introductionmentioning

confidence: 99%

Galanthamine, an anti-cholinesterase drug, effects plant growth and development inArtemisia tridentataNutt. via modulation of auxin and neurotransmitter signaling

Turi

Axwik

Smith

et al. 2014

Plant Signaling & Behavior

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“…, Turi et al. ), which may in turn reduce nitrogen cycling and availability in the soil (Hobbie , ).…”

Section: Introductionmentioning

confidence: 99%

Revision of a state‐and‐transition model to include descriptions of state functional attributes

et al. 2018

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Abstract. Successful conservation of ecosystems and ecosystem services requires understanding the structural-functional relationships underlying resilience to disturbance pressures. State-and-transition models (STMs) are box-and-arrow diagrams conceptualizing system resilience, but many STMs lack functional descriptions. For a cattle-grazed sagebrush steppe ecosystem in northwestern Colorado, we aimed to update an existing STM by incorporating functional descriptions of the states to inform future hypotheses. In this STM, a diverse set of native perennial understory plants define a Diverse state, but long-term exclusion of disturbances to sagebrush results in a shift to a Depauperate state with increased bare ground interspaces and sagebrush dominance. We hypothesized that herbaceous species were inferior competitors to sagebrush over the long term for soil nitrogen. To examine evidence for this hypothesis, develop functional descriptions of the Diverse and Depauperate states, and identify more specific hypotheses for future studies, we measured the following: the mass, C:N, and distribution of the litter layer; nitrogen mineralization rates; nitrate pools; and soil attributes on plots classified as Diverse (n = 5) or Depauperate (n = 5). Plots in the Depauperate state had~20% higher soil bulk density, half the clay and soil moisture concentrations, and 30% lower percent soil nitrogen compared to Diverse state plots; litter layer patchiness was nearly three times greater on the Depauperate plots than on the Diverse plots, but there was no significant difference between states in mean litter layer mass or C:N. We detected no significant differences between states in nitrogen mineralization rates or nitrate pools. This may be due to our sampling design, which examined nitrogen transformation at the plot level rather than at microsites within the plots, or it may be that another resource such as soil moisture is more limiting than nitrogen. Differences in soil texture between plots in the Diverse and Depauperate states may indirectly influence the competitive interactions between sagebrush and native herbaceous understory by controlling available soil resources. These results suggest that the vulnerability of sagebrush steppe ecosystems to state changes may be dependent on soil texture, which is highly variable across this broadly distributed ecosystem. Based on these insights, we present a revised STM and propose future work.

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North American Artemisia species from the subgenus Tridentatae (Sagebrush): A phytochemical, botanical and pharmacological review

Cited by 44 publications

References 90 publications

Chemical composition and acetylcholinesterase inhibitory activity ofArtemisia maderaspatanaessential oil

Chemical composition and acetylcholinesterase inhibitory activity ofArtemisia maderaspatanaessential oil

Galanthamine, an anti-cholinesterase drug, effects plant growth and development inArtemisia tridentataNutt. via modulation of auxin and neurotransmitter signaling

Revision of a state‐and‐transition model to include descriptions of state functional attributes

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