North American COVID-19 Myocardial Infarction (NACMI) Risk Score for Prediction of In-Hospital Mortality

Dehghani, Payam; Schmidt, Christian; García, Santiago; Okeson, Brynn; Grines, Cindy L.; Singh, Avneet; Patel, Rajan A.G.; Wiley, Jose; Htun, Wah Wah; Nayak, Keshav R.; Alraies, M. Chadi; Ghasemzadeh, Nima; Davidson, Laura; Acharya, Deepak; Stone, Jay; Alyousef, Tareq; Case, Brian C.; Dai, Xuming; Hafiz, Abdul Moiz; Madan, Mina; Jaffer, Faoruc A; Shavadia, Jay; Garberich, Ross; Bagai, Akshay; Singh, Jyotpal; Aronow, Herbert D.; Mercado, Nestor; Henry, Timothy D.

doi:10.1016/j.jscai.2022.100404

Cited by 11 publications

(12 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is likely that COVID-19 infection confers additional risk of mortality to patients with STEMI through concomitant pulmonary involvement, as evidenced by abnormal findings on chest x-rays and more mechanical ventilation in this group, and systemic hypercoagulable state. 25 , 26 , 27 …”

Section: Discussionmentioning

confidence: 99%

Mechanical Circulatory Support in Patients With COVID-19 Presenting With Myocardial Infarction

Guddeti

Sanina

Jauhar

et al. 2023

The American Journal of Cardiology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Mechanical Circulatory Support in Patients With COVID-19 Presenting With Myocardial Infarction

Guddeti

Sanina

Jauhar

et al. 2023

The American Journal of Cardiology

View full text Add to dashboard Cite

“…Several factors might partially explain these findings. Deterioration of access to healthcare and reluctance to seek medical care in STEMI symptoms might lead to a more severe condition manifested with OHCA and prehospital death [2,7,9,21,27]. Interestingly, the North American COVID-19 Myocardial Infarction registry reported more frequently atypical symptoms of STEMI with a potentially deceptive impact on patients [21,27].…”

Section: Discussionmentioning

confidence: 99%

“…Deterioration of access to healthcare and reluctance to seek medical care in STEMI symptoms might lead to a more severe condition manifested with OHCA and prehospital death [2,7,9,21,27]. Interestingly, the North American COVID-19 Myocardial Infarction registry reported more frequently atypical symptoms of STEMI with a potentially deceptive impact on patients [21,27]. Overcrowded hospitals with mandatory swab tests and pandemic-specific protocols might also prolong emergency health services' response time.…”

Section: Discussionmentioning

confidence: 99%

Impact of COVID-19 Pandemic on Patients with ST-Segment-Elevation Myocardial Infarction Complicated by Out-of-Hospital Cardiac Arrest

Tokarek

Dziewierz

Zeliaś³

et al. 2022

IJERPH

View full text Add to dashboard Cite

Patients with ST-segment-elevation myocardial infarction (STEMI) treated during the COVID-19 pandemic might experience prolonged time to reperfusion. The delayed reperfusion may potentially aggravate the risk of out-of-hospital cardiac arrest (OHCA) in those patients. Limited access to healthcare, more reluctant health-seeking behaviors, and bystander readiness to render life-saving interventions might additionally contribute to the suggested change in the risk of OHCA in STEMI. Thus, we sought to explore the effects of the COVID-19 outbreak on treatment delay and clinical outcomes of patients with STEMI with OHCA. Overall, 5,501 consecutive patients with STEMI complicated by OHCA and treated with primary percutaneous coronary intervention with stent implantation were enrolled. A propensity score matching was used to obviate the possible impact of non-randomized design. A total of 740 matched pairs of patients with STEMI and OHCA treated before and during the COVID-19 pandemic were compared. A similar mortality and prevalence of periprocedural complications were observed in both groups. However, patients treated during the COVID-19 outbreak experienced longer delays from first medical contact to angiography (88.8 (±61.5) vs. 101.4 (±109.8) [minutes]; p = 0.006). There was also a trend toward prolonged time from pain onset to angiography in patients admitted to the hospital in the pandemic era (207.3 (±192.8) vs. 227.9 (±231.4) [minutes]; p = 0.06). In conclusion, the periprocedural outcomes in STEMI complicated by OHCA were comparable before and during the COVID-19 era. However, treatment in the COVID-19 outbreak was associated with a longer time from first medical contact to reperfusion.

show abstract

“…145,146 Using the NACMI registry, a weighted integer risk score was developed using readily available clinical data at time of STEMI presentation in patients with COVID-19 (respiratory rate >35, prePCI shock, hypoxia, age >55, infiltrates on chest x-ray, creatinine >1.5, diabetes, subjective dyspnea) to accurately predict in-hospital mortality. 147 Updated data from the NACMI registry showed that with the onset of vaccination in 2021, there was a reduction of in-hospital mortality, prePCI shock, and pulmonary manifestations, with an overall encouraging trend towards prepandemic STEMI outcomes in patients who present with STEMI and COVID-19. 148 Immune system stimulation resulting in a hyperinflammatory state resulting in plaque rupture events as well as upregulation of procoagulants and platelet activation resulting in microvascular and coronary thrombosis is one of the proposed mechanisms for STEMI in COVID-19.…”

Section: Acute Coronary Syndromes and Cardiac Catheterization Laborat...mentioning

confidence: 99%

Interaction of COVID-19 With Common Cardiovascular Disorders

Boulos

Freeman

Henry

et al. 2023

Circulation Research

Self Cite

View full text Add to dashboard Cite

The onset and widespread dissemination of the severe acute respiratory syndrome coronavirus-2 in late 2019 impacted the world in a way not seen since the 1918 H1N1 pandemic, colloquially known as the Spanish Flu. Much like the Spanish Flu, which was observed to disproportionately impact young adults, it became clear in the early days of the coronavirus disease 2019 (COVID-19) pandemic that certain groups appeared to be at higher risk for severe illness once infected. One such group that immediately came to the forefront and garnered international attention was patients with preexisting cardiovascular disease. Here, we examine the available literature describing the interaction of COVID-19 with a myriad of cardiovascular conditions and diseases, paying particular attention to patients diagnosed with arrythmias, heart failure, and coronary artery disease. We further discuss the association of acute COVID-19 with de novo cardiovascular disease, including myocardial infarction due to coronary thrombosis, myocarditis, and new onset arrhythmias. We will evaluate various biochemical theories to explain these findings, including possible mechanisms of direct myocardial injury caused by the severe acute respiratory syndrome coronavirus-2 virus at the cellular level. Finally, we will discuss the strategies employed by numerous groups and governing bodies within the cardiovascular disease community to address the unprecedented challenges posed to the care of our most vulnerable patients, including heart transplant recipients, end-stage heart failure patients, and patients suffering from acute coronary syndromes, during the early days and height of the COVID-19 pandemic.

show abstract

North American COVID-19 Myocardial Infarction (NACMI) Risk Score for Prediction of In-Hospital Mortality

Cited by 11 publications

References 31 publications

Mechanical Circulatory Support in Patients With COVID-19 Presenting With Myocardial Infarction

Mechanical Circulatory Support in Patients With COVID-19 Presenting With Myocardial Infarction

Impact of COVID-19 Pandemic on Patients with ST-Segment-Elevation Myocardial Infarction Complicated by Out-of-Hospital Cardiac Arrest

Interaction of COVID-19 With Common Cardiovascular Disorders

Contact Info

Product

Resources

About