North American Efficacy and Safety of a Novel Pediculicide Rinse, Isopropyl Myristate 50% (Resultz)

Kaul, Nalini; Palma, Kathleen G.; Silagy, Stewart; Goodman, Joseph; Toole, John

doi:10.2310/7750.2007.00045

Cited by 29 publications

(20 citation statements)

References 17 publications

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“…Isopropyl myristate 50% (Resultz [Nycomed Canada Inc, Oakville, Ontario, Canada]), a hair rinse that dissolves the waxy exoskeleton of the louse, which leads to dehydration and death of the louse, has recently become available in Canada. 68,69 …”

Section: Occlusive Agentsmentioning

confidence: 99%

Head Lice

Frankowski¹,

Bocchini²

2010

Pediatrics

107

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Head lice infestation is associated with limited morbidity but causes a high level of anxiety among parents of school-aged children. Since the 2002 clinical report on head lice was published by the American Academy of Pediatrics, patterns of resistance to products available overthe-counter and by prescription have changed, and additional mechanical means of removing head lice have been explored. This revised clinical report clarifies current diagnosis and treatment protocols and provides guidance for the management of children with head lice in the school setting.

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Section: Occlusive Agentsmentioning

confidence: 99%

Head Lice

Frankowski¹,

Bocchini²

2010

Pediatrics

107

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“…Mechanical mechanism of action makes development of resistance unlikely. [98] Suffocant (vs. malathion) Physical A randomized multicentre, phase IV trial compared a suffocant [paraffinum liquidum, isopropyl myristate, lauretth-3, butylenes/ethylene/styrene copolymer, ethylene/propylene/ styrene copopymer, carthamus tinctorius (safflower oil) and butylated hydroxytoluene] with malathion for head lice in children, suffocant more effective than malathion and with low incidence of mild adverse events. [87] Essential oils pediculicides vs. suffocant…”

Section: Ivermectin (Vs Malathion)mentioning

confidence: 99%

“…[86] Treatment Increasing resistance and adverse effects have raised concerns about head lice treatments, [87] encouraging search for new treatments [ Table 4]. [88][89][90][91][92][93][94][95][96][97][98][99][100][101][102][103] No available pediculicide is 100% ovicidal, and resistance to lindane, pyrethrins, permethrin, and malathion has been reported. [100] Nits persist after the treatment and may be mistaken for active infestation [ Figure 5].…”

Section: Pediculosismentioning

confidence: 99%

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Insect bite reactions

Singh¹,

Mann²

2013

Indian J Dermatol Venereol Leprol

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Insects are a class of living creatures within the arthropods. Insect bite reactions are commonly seen in clinical practice. The present review touches upon the medically important insects and their places in the classification, the sparse literature on the epidemiology of insect bites in India, and different variables influencing the susceptibility of an individual to insect bites. Clinical features of mosquito bites, hypersensitivity to mosquito bites Epstein-Barr virus NK (HMB-EBV-NK) disease, eruptive pseudoangiomatosis, Skeeter syndrome, papular pruritic eruption of HIV/AIDS, and clinical features produced by bed bugs, Mexican chicken bugs, assassin bugs, kissing bugs, fleas, black flies, Blandford flies, louse flies, tsetse flies, midges, and thrips are discussed. Brief account is presented of the immunogenic components of mosquito and bed bug saliva. Papular urticaria is discussed including its epidemiology, the 5 stages of skin reaction, the SCRATCH principle as an aid in diagnosis, and the recent evidence supporting participation of types I, III, and IV hypersensitivity reactions in its causation is summarized. Recent developments in the treatment of pediculosis capitis including spinosad 0.9% suspension, benzyl alcohol 5% lotion, dimethicone 4% lotion, isopropyl myristate 50% rinse, and other suffocants are discussed within the context of evidence derived from randomized controlled trials and key findings of a recent systematic review. We also touch upon a non-chemical treatment of head lice and the ineffectiveness of egg-loosening products. Knockdown resistance (kdr) as the genetic mechanism making the lice nerves insensitive to permethrin is discussed along with the surprising contrary clinical evidence from Europe about efficacy of permethrin in children with head lice carrying kdr-like gene. The review also presents a brief account of insects as vectors of diseases and ends with discussion of prevention of insect bites and some serious adverse effects of mosquito coil smoke.

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“…One further published assessor-blinded randomised controlled trial, conducted in North America, involving 60 participants, compared isopropyl myristate 50% in cyclomethicone (up to three applications, on days 0, 7 and 14) with a pyrethrin 0.33% plus piperonyl butoxide 4% combination product (two treatments, on days 0 and 7) 11. Patients were assessed on days 0, 7, 14 and 21.…”

Section: Fluids Acting By Physical Propertiesmentioning

confidence: 99%

Update on treatments for head lice

2010

Evid Based Nurs

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Head lice infestation is common, and mainly affects children of primary school age. Treatments include conventional chemical insecticides; fine tooth louse combs; and fluid preparations that work by a physical rather than chemical mode of action. However, each of these fails to eradicate head lice in some patients. Other disadvantages include the long contact time required for certain preparations e.g. 8 hours and the time commitment for combing regimens. Isopropyl myristate 50% in cyclomethicone solution (Full Marks Solution - SSL International) is a new fluid treatment with a physical mode of action that uses a 10-minute contact time. Here, we consider this product in the context of updating advice we gave in 2007 on treatments for head lice.

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North American Efficacy and Safety of a Novel Pediculicide Rinse, Isopropyl Myristate 50% (Resultz)

Abstract: Data suggest that IPM is a safe and effective therapy for the treatment of head lice in children and adults. IPM's mechanical mechanism of action makes development of lice resistance unlikely.

Cited by 29 publications

References 17 publications

Head Lice

Head Lice

Insect bite reactions

Update on treatments for head lice

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