2016
DOI: 10.1016/j.jgr.2015.07.001
|View full text |Cite
|
Sign up to set email alerts
|

North American ginseng influences adipocyte–macrophage crosstalk regulation of inflammatory gene expression

Abstract: BackgroundAdipocyte–macrophage communication plays a critical role regulating white adipose tissue (WAT) inflammatory gene expression. Because WAT inflammation contributes to the development of metabolic diseases, there is significant interest in understanding how exogenous compounds regulate the adipocyte–macrophage crosstalk. An aqueous (AQ) extract of North American (NA) ginseng (Panax quinquefolius) was previously shown to have strong inflammo-regulatory properties in adipocytes. This study examined whethe… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
5
0

Year Published

2016
2016
2022
2022

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 8 publications
(5 citation statements)
references
References 30 publications
0
5
0
Order By: Relevance
“…Moreover, CK induced ROS generation and mRNA expression of proinflammatory genes through activation of both NF-κB and AP-1 pathways in macrophages. These cellular responses are critical in innate immune responses mediated by monocytes and macrophages, as well as by certain ginseng-derived components [45] , [46] ; therefore, our results strongly suggest that CK may be a potential immunomodulatory target for the functional activation of monocytes and macrophages to enhance innate immunity. Further studies regarding the detailed molecular mechanism of CK-mediated immunomodulatory activity and in vivo effects of CK on innate immune conditions are required.…”
Section: Resultsmentioning
confidence: 59%
“…Moreover, CK induced ROS generation and mRNA expression of proinflammatory genes through activation of both NF-κB and AP-1 pathways in macrophages. These cellular responses are critical in innate immune responses mediated by monocytes and macrophages, as well as by certain ginseng-derived components [45] , [46] ; therefore, our results strongly suggest that CK may be a potential immunomodulatory target for the functional activation of monocytes and macrophages to enhance innate immunity. Further studies regarding the detailed molecular mechanism of CK-mediated immunomodulatory activity and in vivo effects of CK on innate immune conditions are required.…”
Section: Resultsmentioning
confidence: 59%
“…Since it was discovered that the paracrine action between macrophages and adipocytes is important in insulin resistance, various naturally occurring botanical components have been proposed to exert anti-inflammatory effects on macrophages and adipocytes. Compound 1 is derived from JA, which is already known to be involved in chronic inflammation. There are few studies in which compounds with the same or similar functional groups as compound 1 are used.…”
Section: Resultsmentioning
confidence: 99%
“…The extracts were then placed in glass vials and stored frozen at −20 °C till being used [ 16 ]. The contents of ginsenoside was measured using high-performance liquid chromatography and size exclusion chromatography [ 17 ].…”
Section: Methodsmentioning
confidence: 99%