Climate change interacts with the sources and cycling of contaminants, such as radionuclides, in the environment. In this review, we discuss the implications of climate change impacts on existing and potential future sources of radionuclides associated with human activities to the marine environment. The overall effect on operational releases of radionuclides from the nuclear and non-nuclear sectors will likely be increased interference or prevention of normal operations due to weather-related events. For certain radioactive waste dumped at sea and sunken nuclear submarines, the impact of climate change and ocean acidification on the release of radionuclides and their subsequent fate in the marine environment should be considered further. Fluxes from secondary sources of radionuclides in the marine and terrestrial environment and cryosphere will change in response to climate change impacts such as sea level rise, warming and changes in precipitation patterns. In addition, climate change impacts may increase the risk of releases of radionuclides from operational and legacy wastes on land to the marine environment. Overall, our synthesis highlights that there is a need to understand and assess climate change impacts on sources of radionuclides to the marine environment to meet environmental and management challenges under future climate scenarios.