Norwegian population norms for the EQ-5D-5L: results from a general population survey

Garratt, Andrew; Hansen, Tonya Moen; Augestad, Liv Ariane; Rand‐Hendriksen, Kim; Stavem, Knut

doi:10.1007/s11136-021-02938-7

Cited by 60 publications

(55 citation statements)

References 36 publications

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“…The patients reported moderate levels of depression and/or anxiety, which would not usually entail difficulties with mobility or washing and dressing. Overall, patients in the study reported more problems across all dimensions compared to the respondents in the study that collected the Norwegian EQ-5D norm data (Garratt et al, 2021).…”

Section: Discussionmentioning

confidence: 80%

“…A minority of patients reported problems on the Mobility and Self-care; 24.3 and 15.2%, respectively, whilst a large majority of patients in the sample reported some level of problems on Usual activities and Pain/ discomfort (78.3 and 76.2%, respectively). Figure 1 shows a comparison between the proportion of patients in the present study and the proportion of participants in the study obtaining data for the general population norms (Garratt et al, 2021) reporting "No problems" on the sub-scales. The patient cohort reported more problems on all dimensions compared to the norm population.…”

Section: Known-groups Validitymentioning

confidence: 98%

“…A study is underway to acquire a value set for Norway, but this is not yet available (NIPH, 2019;Moen Hansen et al, 2020). In such cases it is recommended to use a crosswalk (or mapping) system (NICE, 2019), and this crosswalk system was used in a recent study obtaining Norwegian EQ-5D population norms (Garratt et al, 2021). The same crosswalk methodology was used in the present study when calculating the EQ-5D value.…”

Section: Eq-5dmentioning

confidence: 99%

“…A score of 1.000 (i.e., full health) corresponds to a health profile of "11,111, " i.e., reporting "No problems" across all dimensions. Healthy populations typically report EQ-5D values close to 1; for instance, the study obtaining data from the Norwegian general population found a mean value of 0.805 in a postal survey (Garratt et al, 2021). Note also that when reporting the EQ-5D values it is common to use three decimals (Devlin et al, 2020).…”

Section: Eq-5dmentioning

confidence: 99%

“…We then compared the proportion of patients reporting "No problems" to patients reporting any other levels of severity (Devlin et al, 2020). Using the recently published Norwegian population norms (Garratt et al, 2021), we explore known-groups validity by comparing the patients in our study and participants in the general population study who reported "no problems" vs. all other levels of severity. For known-group validity within the sample, we divided the patients into quartiles based on severity of depression and anxiety symptoms as recorded by the BDI-II and BAI scores.…”

Section: Statistical Analysesmentioning

confidence: 99%

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Self-Reported Health in Patients on or at Risk of Sick Leave Due to Depression and Anxiety: Validity of the EQ-5D

et al. 2021

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Objectives: The EQ-5D is a generic, self-report measure of health that is increasingly used in clinical settings, including mental health. The EQ-5D captures health using five dimensions: Mobility, Self-care, Usual activities, Pain/discomfort, and Anxiety/Depression. The validity of the EQ-5D is previously unexplored in patients on or at risk of sick leave due to depression and anxiety. The study’s aim was to examine its validity in this group of patients.Methods: Baseline data were collected from self-report questionnaires in an observational study (N=890) at a Norwegian outpatient-clinic. Participants were adults on or at risk of sick leave due to depression and anxiety who were referred for treatment by general practitioners. The crosswalk methodology was applied to estimate the EQ-5D value. Validity was assessed by comparing responses on the EQ-5D with the Beck Depression Inventory-II (BDI-II), the Beck Anxiety Inventory (BAI), and Subjective Health Complaints (SHC). An ordinal regression model was used to assess known-groups validity. Convergent validity was assessed using Pearson’s correlation coefficient, and a multivariate regression model that included sociodemographic characteristics.Results: The mean EQ-5D value was 0.631, indicating reduced health status compared to “full health” anchored at 1.0, and patients reported moderate levels of depression and anxiety. Ordinal regression indicated that the EQ-5D could discriminate between different levels of symptom severity for depression and anxiety. The EQ-5D value showed significant correlation with the clinical measures; r=−0.52 for the BDI-II, r=−0.49 for the BAI, and r=−0.44 for SHC. The multivariate regression showed that the clinical variables significantly predicted the EQ-5D value, explaining 40.1% of the variance. Depression and anxiety scores were the largest determinants of EQ-5D value, respectively, whilst sick leave, subjective health complaints, and gender made moderate contributions.Conclusion: The EQ-5D showed indication of validity in patients on or at risk of sick leave due to depression and anxiety in the present study. The EQ-5D value was sensitive to both symptom severity and functional impairment in the form of sick leave. The findings support the EQ-5D as a feasible and relevant measure of health status in these patients.

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Section: Discussionmentioning

confidence: 80%

Section: Known-groups Validitymentioning

confidence: 98%

Section: Eq-5dmentioning

confidence: 99%

Section: Eq-5dmentioning

confidence: 99%

Section: Statistical Analysesmentioning

confidence: 99%

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Self-Reported Health in Patients on or at Risk of Sick Leave Due to Depression and Anxiety: Validity of the EQ-5D

et al. 2021

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Health‐related quality of life among transthyretin amyloid cardiomyopathy patients

et al. 2023

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Aims Transthyretin amyloid cardiomyopathy (ATTR CM) is a progressive and severe heart disease with physical and psychological implications. The Nordic PROACT study was conducted to investigate the health‐related quality of life (HRQoL) in ATTR CM patients. Methods and results The Nordic PROACT study was a cross‐sectional non‐interventional study conducted in 12 cardiology hospital clinics across Norway, Sweden, Finland and Denmark. Men and women aged ≥18 years diagnosed with symptomatic ATTR CM were included. The investigator provided information on medical history, biomarkers, current treatment, co‐morbidities and disease severity according to the New York Heart Association (NYHA) class and the National Amyloidosis Centre (NAC) staging. Patients completed the HRQoL questionnaires in the form of the Kansas City Cardiomyopathy Questionnaire (KCCQ), the EQ‐5D‐5L index with Visual Analog Scale (VAS), and the Major Depression Inventory (MDI). A total of 169 patients (mean ± SD age 77.7 ± 6.2 years) were included. Ninety‐two per cent were men. Seventy‐six per cent had wildtype ATTR CM (ATTRwt CM) and 15% had a hereditary form of ATTR CM (ATTRv CM) while 9% were genetically unclassified. Most patients were in NYHA class II (54%) and NAC stage 1 (53%). Participation in randomized clinical trials (RCT) was noted in 58% of the patients. The 169 ATTR CM patients had a mean ± SD KCCQ score of 64.3 ± 23.1 for total symptom score, 64.8 ± 20.9 for overall summary score (OSS) and 65.1 ± 21.5 for clinical summary score. The EQ‐5D‐5L total utility score was 0.8 ± 0.2 and the EQ‐5D‐5L VAS score was 62.9 ± 20.6. The vast majority (89%) did not report any signs of depression. Patients with ATTRv CM had a higher KCCQ OSS as compared with ATTRwt CM, while EQ‐5D‐5L utility score, EQ‐5D‐5L VAS and MDI were similar. Non‐RCT participants had a poorer HRQoL as compared with RCT participants as reflected in lower KCCQ OSS and EQ‐5D‐5L VAS scores and a higher MDI score. Patients with higher NYHA classes and NAC disease stages had a poorer HRQoL as demonstrated by lower KCCQ and EQ‐5D‐5L scores and higher MDI scores. Correlation between KCCQ, EQ‐5D‐5L and MDI and the covariate NYHA class remained significant (P < 0.05) after adjusting for multiple testing. Conclusions KCCQ scores were lower than previously reported for patients with other heart diseases of non‐ATTR CM origin. The HRQoL measures correlated well to NYHA class and NAC disease stage. The prevalence of depression appeared to be low.

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Associations of long‐term clinical recovery and improved quality of life across ICD‐11 chronic pain categories in a real‐world registry study

Farnes,

Granan,

Jacobsen

et al. 2024

European Journal of Pain

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BackgroundThere is little knowledge of what factors are needed for successful chronic pain management. We aim to identify psychosocial and treatment predictors of clinical recovery and improved quality of life (QOL) at 12‐month follow‐up across three chronic pain groups, based on the International Classification of Diseases‐11: neuropathic pain, secondary non‐neuropathic pain, and primary pain. Furthermore, we investigate baseline differences across diagnostic groups.MethodsThe sample included baseline and 12‐month follow‐up data from 1056 chronic pain patients from the Oslo University Hospital's Pain Registry. Logistic regression models investigated longitudinal associations between psychosocial and treatment characteristics, and the outcome measures clinical recovery and improved QOL. Characteristics were compared across the diagnostic groups.ResultsIncreased odds of clinical recovery and improved QOL were seen in patients receiving invasive treatment (OR = 8.04, 95% CI = 3.50–19.40; OR = 5.47, 95% CI = 2.42–12.86), while decreased odds of clinical recovery were seen for secondary non‐neuropathic pain patients with pain‐related disability (0.05, 95% CI = 0.01–0.29). In comparing baseline characteristics, neuropathic pain patients had lower QOL, and more severe insomnia compared to the other groups.ConclusionInvasive treatment modalities were strongly associated with clinical recovery and improved QOL. Although this could be due to patient selection, it does warrant further examination as an intervention alternative for chronic pain. Intervention efficacy, risk factors and predictors of clinical recovery across diagnostic groups should be further investigated through longitudinal RCTs.SignificanceThis observational study indicates a potential advantage in sustained recovery for pre‐selected individuals with chronic pain who undergo invasive treatments. The relationship between sustained recovery and psychosocial factors differs across neuropathic, secondary non‐neuropathic, and primary pain patients. This suggests that employing ICD‐11 for classifying patients into mechanistically distinct pain groups could inform the evaluation and management of chronic pain. Furthermore, factors previously identified as negative indicators for long‐term outcomes in chronic pain cohorts were not clinically significant in this study.

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Norwegian population norms for the EQ-5D-5L: results from a general population survey

Cited by 60 publications

References 36 publications

Self-Reported Health in Patients on or at Risk of Sick Leave Due to Depression and Anxiety: Validity of the EQ-5D

Self-Reported Health in Patients on or at Risk of Sick Leave Due to Depression and Anxiety: Validity of the EQ-5D

Health‐related quality of life among transthyretin amyloid cardiomyopathy patients

Associations of long‐term clinical recovery and improved quality of life across ICD‐11 chronic pain categories in a real‐world registry study

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