Noscapine suppresses angiotensin converting enzyme inhibitors‐induced cough

Mobed, Ahmad; Jenabi, A; Jabbari, Mosadegh; Zolfaghari, Mohammad I; Javanmardi, Sahar Z; Mahmoudian, M; Bastani, Bahar

doi:10.1111/j.1440-1797.2005.00429.x

Cited by 30 publications

(15 citation statements)

References 19 publications

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“…Literature for PCOS clearly suggests an interplay of hormonal and non-hormonal factors that influences microenvironment of ovary culminating in deranged hypothalamus-pituitary-ovarian (HPO) axis. Ovary and brain are among the tissues known to have noscapine receptors, which are hypothalamus specific [31,32] and could possibly affect the HPO axis. Significantly higher uptake of 99m Tc-noscapine in ovary as compared to simple technetium pertechnetate (TcO 4 - ), strongly suggests receptor mediated specificity of the drug for ovarian tissue.…”

Section: Discussionmentioning

confidence: 99%

“…In case of noscapine too, apart from specific uptake at sites known to accumulate injected noscapine, there are a few other observations which confirm that 99m Tc-noscapine behaves substantially like the parent molecule. The blood clearance graph is typically biphasic in both cases with similar disappearance rates and other parameters [32,33] (Figure 2). The biological half-life of the radiopharmaceutical was found to be t 1/2 (Fast) ≃ 12 minutes; t 1/2 (Slow) ≃ 3 h and 50 minutes, while the reported t 1/2 of the parent molecule is also 3 h (slow phase) [18].…”

Section: Discussionmentioning

confidence: 99%

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Radiolabeling, biodistribution and gamma scintigraphy of noscapine hydrochloride in normal and polycystic ovary induced rats

et al. 2010

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BackgroundNoscapine, an alkaloid from Papaver somniferum, widely used as an antitussive, is being clinically studied in the treatment of polycystic ovary syndrome (PCOS) and a few other cancers primarily because of its anti-angiogenesis properties. With the advent of diverse application of noscapine, we sought to determine whether the radiolabeling method can be useful in studying uptake and kinetics of the molecule in-vivo. Specific objectives of this study were to radiolabel noscapine with Technetium-99m (Tc-99m), to determine its organ biodistribution in rat model and study its uptake kinetics in PCOS model.MethodsA method for radiolabeling noscapine with Tc-99m was standardized using stannous reduction method and its in vitro and in vivo stability parameters were studied. The radiopharmaceutical was also evaluated for blood kinetics and biodistribution profile. An animal model of PCOS was created by using antiprogesterone RU486 and uptake of 99mTc-noscapine in normal and PCOS ovaries was compared using gamma scintigraphy.ResultsNoscapine hydrochloride was successfully radiolabeled with Tc-99m with high labeling efficiency and in vitro stability. Most of the blood clearance of the drug (80%) took place in first hour after intravascular injection with maximum accumulation being observed in liver, spleen, kidney followed by the ovary. At 4 hours post injection, radiolabeled complex accumulation doubled in PCOS ovaries in rats (0.9 ± 0.03% ID/whole organ) compared to normal cyclic rats (0.53 ± 0.01% ID/whole organ). This observation was further strengthened by scintigraphic images of rats taken at different time intervals (1 h, 2 h, 4 h, and 24 h) where SPECT images suggested discrete accumulation in the PCOS ovaries.ConclusionThrough our study we report direct radiolabeling of noscapine and its biodistribution in various organs and specific uptake in PCOS that may show its utility for imaging ovarian pathology. The increased ovarian uptake in PCOS may be related to its receptor binding suggesting possible role of 99mTc-noscapine in PCOS diagnostics and therapeutics.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Radiolabeling, biodistribution and gamma scintigraphy of noscapine hydrochloride in normal and polycystic ovary induced rats

et al. 2010

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“…Ninety percent of patients experienced a complete response within 10 days. 20 Altogether, noscapine has potent antitussive activity due in part to its actions on bradykinin responses, which, as described below, may additionally render it a useful therapy for strokes.…”

Section: Noscapine Coughs Out Its First Medicinal Use: Antitussivementioning

confidence: 99%

The Noscapine Chronicle: A Pharmaco‐Historic Biography of the Opiate Alkaloid Family and its Clinical Applications

Rida

LiVecche

Ogden

et al. 2015

Medicinal Research Reviews

113

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Given its manifold potential therapeutic applications and amenability to modification, noscapine is a veritable “Renaissance drug” worthy of commemoration. Perhaps the only facet of noscapine’s profile more astounding than its versatility is its virtual lack of side effects and addictive properties, which distinguishes it from other denizens of Papaver somniferum. This review intimately chronicles the rich intellectual and pharmacological history behind the noscapine family of compounds, the length of whose arms was revealed over decades of patient scholarship and experimentation. We discuss the intriguing story of this family of nontoxic alkaloids, from noscapine’s purification from opium at the turn of the 19th century in Paris to the recent torrent of rationally designed analogs with tremendous anticancer potential. In between, noscapine’s unique pharmacology; impact on cellular signaling pathways, the mitotic spindle, and centrosome clustering; use as an antimalarial drug and cough suppressant; and exceptional potential as a treatment for polycystic ovarian syndrome, strokes, and diverse malignancies are catalogued. Seminal experiments involving some of its more promising analogs, such as amino-noscapine, 9-nitronoscapine, 9-bromonoscapine, and reduced bromonoscapine, are also detailed. Finally, the bright future of these oftentimes even more exceptional derivatives is described, rounding out a portrait of a truly remarkable family of compounds.

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“…1 Noscapine has been used for decades almost exclusively as an antitussive, and even now may have new applications as a cough syrup. 2 Joshi's group 3 , has shown that noscapine can destroy tumors or at least slow their growth and have interesting antimicrotubule properties that differ from the other two principal classes of anti-cancer drugs that target microtubules.…”

Section: Introductionmentioning

confidence: 99%

A Simple and Rapid Flow‐Injection Chemiluminescence Method for the Determination of Noscapine with Ru(phen)₃²⁺‐Ce(IV) System

2007

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A new flow injection chemiluminescence (CL) system was used for the determination of noscapine. This technique is based on the reduction effect of noscapine on the Ru(phen)3(3+), which is produced by reaction between Ru(phen)3(2+) and acidic Ce(IV) solutions, and this rapid reduction produces strong CL. Calibration plots were linear over the range of 3.0 x 10(-7) - 2.0 x 10(-6) mol L(-1) and 2.0 x 10(-6) - 2.0 x 10(-4) mol L(-1). The CL intensity was so high, that it is able to produce a detection limit of 6.6 x 10(-8) M noscapine (3sigma). The relative standard deviation of 2.0 x 10(-6) M noscapine was 1.0% (n=10). The proposed method was successfully applied for the flow injection determination of noscapine in cough and Tonin syrup samples. The results of real sample analyses show good recovery percentages (97.3-102.4%). The minimum sampling rate was 100 samples per hour.

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Noscapine suppresses angiotensin converting enzyme inhibitors‐induced cough

Abstract: Noscapine, possibly by inhibition of bradykinin synthesis, eliminates ACEI-induced cough in the majority of patients and allows them to continue with ACEI therapy.

Cited by 30 publications

References 19 publications

Radiolabeling, biodistribution and gamma scintigraphy of noscapine hydrochloride in normal and polycystic ovary induced rats

Radiolabeling, biodistribution and gamma scintigraphy of noscapine hydrochloride in normal and polycystic ovary induced rats

The Noscapine Chronicle: A Pharmaco‐Historic Biography of the Opiate Alkaloid Family and its Clinical Applications

A Simple and Rapid Flow‐Injection Chemiluminescence Method for the Determination of Noscapine with Ru(phen)₃²⁺‐Ce(IV) System

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Noscapine suppresses angiotensin converting enzyme inhibitors‐induced cough

Abstract: Noscapine, possibly by inhibition of bradykinin synthesis, eliminates ACEI-induced cough in the majority of patients and allows them to continue with ACEI therapy.

Cited by 30 publications

References 19 publications

Radiolabeling, biodistribution and gamma scintigraphy of noscapine hydrochloride in normal and polycystic ovary induced rats

Radiolabeling, biodistribution and gamma scintigraphy of noscapine hydrochloride in normal and polycystic ovary induced rats

The Noscapine Chronicle: A Pharmaco‐Historic Biography of the Opiate Alkaloid Family and its Clinical Applications

A Simple and Rapid Flow‐Injection Chemiluminescence Method for the Determination of Noscapine with Ru(phen)32+‐Ce(IV) System

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A Simple and Rapid Flow‐Injection Chemiluminescence Method for the Determination of Noscapine with Ru(phen)₃²⁺‐Ce(IV) System