Nose-to-brain delivery of insulin enhanced by a nanogel carrier

Picone, Pasquale; Sabatino, Maria Antonietta; Ditta, Lorena Anna; Amato, Antonella; Biagio, Pier Luigi San; Mulè, Flavia; Giacomazza, Daniela; Dispenza, Clelia; Carlo, Marta Di

doi:10.1016/j.jconrel.2017.11.040

Cited by 108 publications

(73 citation statements)

References 86 publications

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“…The authors proposed the possibility that viral brain infection starts from the olfactory neurons (Butowt and Bilinska, 2020). Nose-to-brain route is use in biomedicine to brain drug delivery, avoiding the difficulties due to the BBB and the problems connected with systemic administration (Picone et al, 2018). The circulation of the virus in the bloodstream its interaction with the capillary endothelium and the subsequent formation of the viral particles could determine the destruction of the brain capillary endothelium allowing the access of the virus to the brain.…”

Section: Direct Effects Of Covid-19 On Brainmentioning

confidence: 99%

Potential neurological effects of severe COVID-19 infection

Nuzzo

Picone

2020

Neuroscience Research

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Coronaviruses (CoVs) are large positive stranded enveloped RNA viruses that generally cause enteric and respiratory diseases in humans and in animals. Most human CoVs have recently attracted global attention to their lethal potential and great infectious capacity. A highly pathogenic CoV, called COVID-19 or SARS-CoV-2, dramatically emerged in December 2019 in Wuhan, China. This new CoV has caused severe pneumonia in China and rapidly spreads around the world, the COVID-19 pandemic. Growing evidence pieces show that viruses, such as CoVs, can enter the central nervous system from different pathways and inducing neurotoxicity. Therefore, it is urgent to make clear whether SARS-CoV-2 has access to the central nervous system and can cause direct neuronal effects. Moreover, a brain-lung-brain axis is been proposed from the scientific community where severe neurological dysfunction and injury are associated with lung injury, and vice versa. In this axis, virus-induced inflammation and oxidative stress could be the common mechanisms responsible for CoV neurological symptoms. Therefore, is important to make clear whether SARS-CoV-2 lung damage can cause direct or indirect neuronal effects.

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Section: Direct Effects Of Covid-19 On Brainmentioning

confidence: 99%

Potential neurological effects of severe COVID-19 infection

Nuzzo

Picone

2020

Neuroscience Research

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“…Most of these nanogels can be taken up by tumor cells due to their nanometer size, providing the drug delivery directly to specific sites within the cell. In this way, side effects can be minimized and bioavailability and activity can be increased [ 94 , 104 , 109 , 110 ].…”

Section: Nanogelsmentioning

confidence: 99%

An Updated Review of Macro, Micro, and Nanostructured Hydrogels for Biomedical and Pharmaceutical Applications

et al. 2020

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Hydrogels are materials with wide applications in several fields, including the biomedical and pharmaceutical industries. Their properties such as the capacity of absorbing great amounts of aqueous solutions without losing shape and mechanical properties, as well as loading drugs of different nature, including hydrophobic ones and biomolecules, give an idea of their versatility and promising demand. As they have been explored in a great number of studies for years, many routes of synthesis have been developed, especially for chemical/permanent hydrogels. In the same way, stimuli-responsive hydrogels, also known as intelligent materials, have been explored too, enhancing the regulation of properties such as targeting and drug release. By controlling the particle size, hydrogel on the micro- and nanoscale have been studied likewise and have increased, even more, the possibilities for applications of the so-called XXI century materials. In this paper, we aimed to produce an overview of the recent studies concerning methods of synthesis, biomedical, and pharmaceutical applications of macro-, micro, and nanogels.

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“…Picone et al prepared poly( N -vinyl pyrrolidone)-based nanogels prepared by e-beam irradiation with a covalent attachment of insulin for brain delivery [ 48 ]. Intranasal administration of the formulation revealed the absence of immunogenic response of the nasal mucosa in vivo which was evident by the levels of IL-6, IL-1β, IL-10 and TGFβ in mouse total brains which were comparable with the controls.…”

Section: Preparation Of Nanogelsmentioning

confidence: 99%

“…The brain uptake of the formulation was enhanced when compared to the administration of the free insulin. A significant amount of the insulin was found in the anterior and cerebellar regions of the mouse brain suggesting that the olfactory and trigeminal nerve pathways are involved in the transportation of the drug to the brain [ 48 ]. In another report by Picone et al carboxyl-functionalized poly( N -vinyl pyrrolidone)-based nanogel system was prepared by ionizing radiation with covalent attachment of insulin [ 44 ].…”

Section: Preparation Of Nanogelsmentioning

confidence: 99%

Design and Efficacy of Nanogels Formulations for Intranasal Administration

Aderibigbe

Naki

2018

Molecules

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Nanogels are drug delivery systems that can bypass the blood-brain barrier and deliver drugs to the desired site when administered intranasally. They have been used as a drug delivery platform for the management of brain diseases such as Alzheimer disease, migraine, schizophrenia and depression. nanogels have also been developed as vaccine carriers for the protection of bacterial infections such as influenza, meningitis, pneumonia and as veterinary vaccine carriers for the protection of animals from encephalomyelitis and mouth to foot disease. It has been developed as vaccine carriers for the prevention of lifestyle disease such as obesity. Intranasal administration of therapeutics using nanogels for the management of brain diseases revealed that the drug transportation was via the olfactory nerve pathway resulting in rapid drug delivery to the brain with excellent neuroprotective effect. The application of nanogels as vaccine carriers also induced significant responses associated with protective immunity against selected bacterial and viral infections. This review provides a detailed information on the enhanced therapeutic effects, mechanisms and biological efficacy of nanogels for intranasal administration.

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Nose-to-brain delivery of insulin enhanced by a nanogel carrier

Cited by 108 publications

References 86 publications

Potential neurological effects of severe COVID-19 infection

Potential neurological effects of severe COVID-19 infection

An Updated Review of Macro, Micro, and Nanostructured Hydrogels for Biomedical and Pharmaceutical Applications

Design and Efficacy of Nanogels Formulations for Intranasal Administration

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