Nosocomial Blood Stream Infections in Adult Patients Admitted to Al Jumhoria Hospital -Benghazi-Libya

Abstract

As little information of antibiotic resistance in Libya is known.This study included 937 patients admitted to Al Jamhoryia hospital, Benghazi during 20092010.The results showed that rate of nosocomial blood stream infection (BSI) was 28% in 2009 and 27% in 2010 with the highest percentage of ICU (61%) in 2009. This study also showed that in 2009, the most frequently isolated bacteria among staphylococci was methicillin resistance Staphylococcus aureus (MRSA). However methicillin resistant Coagulase negative staphylococci accounted for (27.4%) Klebsiellapneumoniaere presented the highest percentage followed by Escherichia coli, S. hominis, S. aurues, S. epidermides, and Acinetobacterbaumannii. The rate of infection recorded in 2010 was (52.5%). This study showed that MRSA was the most prevalent pathogen. S. aurues isolates represented the highest percentage among all bacteria isolated (24.8%) followed by E. coli % S. hominis and S. epidermides. The occurrence of Extended Spectrum Beta-lactamase (ESBL) producing bacteria was 15.9% and 14.9% in 2009 and 2010 respectively. Antimicrobial sensitivity testing showed that Gram-positive isolates exhibited higher sensitivity patterns toward Rifampin (95.8%) followed by Teicoplanin (91.6%), Ciprofloxacin (90.2%), Vancomycin (87.4%), and Linezolid (84). High rate of resistance was observed against penicillins and 3rd generation cephalosporins. The rate of antibiotic resistant bacteria causing NBSI is increasing among Gram-positive and negative bacteria and creates a serious health problem in hospitals.