Nosocomial bloodstream infections in a nationwide study: comparison between solid organ transplant patients and the general population

Camargo, Luís Fernando Aranha; Marra, Alexandre R.; Pignatari, Antônio Carlos Campos; Sukiennik, Teresa; Behar, P.P.P.; Medeiros, Eduardo Alexandrino; Ribeiro, Julival; Girão, Evelyne Santana; Corrêa, Luci; Guerra, Carla Morales; Brites, Carlos; Pereira, Carlos Alberto Pires; Carneiro, Irna Carla do Rosário Souza; Reis, Marise A. B.; Souza, Marta Antunes de; Barata, Cristina U.; Edmond, Michael B.

doi:10.1111/tid.12356

Cited by 46 publications

(42 citation statements)

References 23 publications

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“…In addition to these studies on XDR A baumannii, several other studies investigated carbapenem resistance in A baumannii and found it was quite common. 8,15,20,27,28 Carbapenem resistance in A baumannii in these studies ranged from 15.3% from Reddy and colleagues 27 to 75% from De Gouvea and colleagues. 8,15 Six studies investigated Pseudomonas aeruginosa.…”

Section: Prevalence Of Pathogens In Solid Organ Transplantmentioning

confidence: 92%

“…8,15,20,27,28 Carbapenem resistance in A baumannii in these studies ranged from 15.3% from Reddy and colleagues 27 to 75% from De Gouvea and colleagues. 8,15 Six studies investigated Pseudomonas aeruginosa. 6,8,[20][21][22]24,30 Carbapenem resistance rates were high ranging from 18% 24 to 87.5%.…”

Section: Prevalence Of Pathogens In Solid Organ Transplantmentioning

confidence: 92%

“…8 With the exception of the studies from Al-Hasan and colleagues, 6 Azap and colleagues, 13 and Riera and colleagues, 9 the incidence of ESBL production in enteric pathogens was at least 40%. [6][7][8][9]11,12,14,21,23,25 Two other studies reported the proportion of enteric bacilli that were MDR (14.5% and 54.8%, respectively), but did not specify if these were ESBL producing or not. 26,28 One other study looked at the number of patients who were colonized with ESBL producing pathogens before liver transplantation.…”

Section: Prevalence Of Pathogens In Solid Organ Transplantmentioning

confidence: 93%

“…8,15 Six studies investigated Pseudomonas aeruginosa. 6,8,[20][21][22]24,30 Carbapenem resistance rates were high ranging from 18% 24 to 87.5%. 8 Additionally, in the study by Mlynarczyk and colleagues, 24 production of metallo-b lactamase was found in 10.5% of isolates.…”

Section: Prevalence Of Pathogens In Solid Organ Transplantmentioning

confidence: 99%

“…Data for methicillin-resistant Staphylococcus aureus (MRSA) were limited, with only 4 studies reviewed reporting on MRSA. [7][8][9][10] The prevalence of MRSA had wide variability being as low as 18% 9 and as high as 80%. 10 Few of these studies looked at Enterococcus spp.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Antibiotic-Resistant Infections and Treatment Challenges in the Immunocompromised Host

Dumford

Skalweit

2016

Infectious Disease Clinics of North America

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Section: Prevalence Of Pathogens In Solid Organ Transplantmentioning

confidence: 92%

Section: Prevalence Of Pathogens In Solid Organ Transplantmentioning

confidence: 92%

Section: Prevalence Of Pathogens In Solid Organ Transplantmentioning

confidence: 93%

Section: Prevalence Of Pathogens In Solid Organ Transplantmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Antibiotic-Resistant Infections and Treatment Challenges in the Immunocompromised Host

Dumford

Skalweit

2016

Infectious Disease Clinics of North America

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Multidrug‐resistant organisms in liver transplant: Mitigating risk and managing infections

Hand

Patel

2016

Liver Transpl

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Liver transplant (LT) recipients are vulnerable to infections with multidrug-resistant (MDR) pathogens. Risk factors for colonization and infection with resistant bacteria are ubiquitous and unavoidable in transplantation. During the past decade, progress in transplantation and infection prevention has contributed to the decreased incidence of infections with methicillin-resistant Staphylococcus aureus. However, even in the face of potentially effective antibiotics, vancomycinresistant enterococci continue to plague LT. Gram-negative bacilli prove to be more problematic and are responsible for high rates of both morbidity and mortality. Despite the licensure of novel antibiotics, there is no universal agent available to safely and effectively treat infections with MDR gram-negative organisms. Currently, efforts dedicated toward prevention and treatment require involvement of multiple disciplines including transplant providers, specialists in infectious diseases and infection prevention, and researchers dedicated to the development of rapid diagnostics and safe and effective antibiotics with novel mechanisms of action.Liver Transplantation 22 1143-1153 2016 AASLD. Even with great improvements in infection prevention, surgical technique, and immunosuppression, bacterial infections remain responsible for poor outcomes in liver transplantation (LT). In an era of prolonged wait times, repeated and unavoidable exposures to both health care and antibiotics place LT candidates and recipients at high risk for both colonization and infection with multidrug-resistant organisms (MDROs).Multidrug resistance is frequently defined as bacteria resistant to at least 1 agent in at least 3 different antibiotic classes.(1) Despite this accepted definition, the definitions applied in studies describing MDROs are variable. MDRO colonization has been associated with subsequent infection and surgical complexities, requirement for immunosuppressive therapy, and necessary invasive interventions (eg, central venous catheters, urinary catheters, and mechanical ventilation) also add to the risk of MDRO infection in this susceptible population. In the absence of posttransplant complications, bacterial infections are more common early after LT.(2) Donor transmission of a MDRO has rarely been reported.Delays in effective empirical therapy, lack of experience with older and newer agents, and ever-changing susceptibility profiles in the setting of inadequate source control or selective antibiotic pressures contribute to the difficulties in treating patients infected with MDROs, specifically multidrug-resistant (MDR) gram-negative bacilli. In this review, we highlight risk factors and available treatment for some of the more common and problematic MDROs encountered in LT.

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Pseudomonas aeruginosa Infections in Transplant: Epidemiology and Emerging Treatment Options

Hogan¹,

Hill²,

Sifri³

2020

Emerging Transplant Infections

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Nosocomial bloodstream infections in a nationwide study: comparison between solid organ transplant patients and the general population

Abstract: Antimicrobial resistance is higher, particularly among gram-negative bacteria in the transplant population, although the overall mortality rate between transplant and non-transplant patients with nosocomial BSI is similar.

Cited by 46 publications

References 23 publications

Antibiotic-Resistant Infections and Treatment Challenges in the Immunocompromised Host

Antibiotic-Resistant Infections and Treatment Challenges in the Immunocompromised Host

Multidrug‐resistant organisms in liver transplant: Mitigating risk and managing infections

Pseudomonas aeruginosa Infections in Transplant: Epidemiology and Emerging Treatment Options

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