Nosocomial COVID-19 Incidence and Secondary Attack Rates among Patients of Tertiary Care Center, Zurich, Switzerland

Wolfensberger, Aline; Kufner, Verena; Zaheri, Maryam; Zeeb, Marius; Nortes, Isabelle; Schreiber, Peter W.; Vázquez, Miriam; Schärer, V; Scheier, Thomas; Schmutz, Stefan; Probst, Eliane; Saleschus, Dirk; Huber, Michael; Rampini, S; Zingg, Walter

doi:10.3201/eid2810.220321

Cited by 8 publications

(8 citation statements)

References 13 publications

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“…Regarding the proportion of nosocomial infections, our data are similar to those of other authors who reported 7.4% nosocomial infection. 6 In the study published by Khan et al, 7 patients with nosocomial COVID-19 had a 30-day mortality rate of 18.5%. The mortality rate in our study was strikingly similar, 18.3%.…”

Section: Discussionmentioning

confidence: 97%

Identifying Adverse Events in Patients Hospitalized in Isolation or Quarantine Due to COVID-19

et al. 2023

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Background: This study evaluated the adverse events of COVID-19 isolation or quarantine in patients with nosocomial SARS-CoV-2 infection admitted to the Hospital Universitario Insular de Gran Canaria.Methods: This is a retrospective cohort study with 30-day follow-up of 126 patients diagnosed with nosocomial COVID-19 through polymerase chain reaction test, between May 1 and June 30, 2022, in a 500-bed university hospital in the island of Gran Canaria.Results: Between May 1 and July 30, 2022, a total of 2250 patients were admitted to the Hospital Universitario Insular de Gran Canaria; 126 of them were diagnosed with nosocomial COVID-19 through a polymerase chain reaction test. The rate of nosocomial COVID-19 infection was 5.6%. From the 126 patients of the study population, 27 experienced an adverse event (21.4%) and 2 experienced 2 adverse events (1.6%) due to COVID-19 isolation or quarantine. Thus, a total of 31 adverse events occurred in 29 patients. These events included the following: delay in transfer to other centers of 11 patients who were pending of receiving a negative COVID-19 test result (35.5%), delay or cancellation of diagnostic tests in 9 patients (29%), delay or cancellation of doctor visit in 7 patients (22.6%), and delay or cancellation of surgical or other interventions in 4 patients (12.9%).Conclusions: Because of the adverse consequences of nosocomial COVID-19 infection in hospitalized patients, measures should be observed for the prevention and control of nosocomial infection transmission, and adverse events related to patient safety issues in health care in isolated or quarantined COVID-19 patients should be prevented.

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Section: Discussionmentioning

confidence: 97%

Identifying Adverse Events in Patients Hospitalized in Isolation or Quarantine Due to COVID-19

et al. 2023

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“…Outbreaks of SARS-CoV-2 variants were investigated in three studies. Wolfensberger et al showed in a mostly unvaccinated population that high viral loads among index patients and prolonged contact time in shared rooms played critical roles in healthcare-associated Alpha variant transmission [44] . O'Grady et al .…”

Section: Discussionmentioning

confidence: 99%

Risk factors for nosocomial COVID-19 in a French university hospital

Dinh¹,

Gallouche²,

Terrisse³

et al. 2023

Infectious Diseases Now

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“…Many of our patients who contracted COVID-19 from an outbreak were exposed to the infection by a patient that they shared a room with. One study from Switzerland 11 observed that prolonged contact time in a shared hospital room is essential in patients acquiring a HA infection.…”

Section: Discussionmentioning

confidence: 99%

Incidence and outcome of hospital-acquired COVID-19 infections in secondary and tertiary care hospitals in the era of COVID-19 vaccinations

Helanne,

Forsblom,

Kainulainen

et al. 2023

ASHE

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Objective: Hospital-acquired (HA) COVID-19 infections are known to increase morbidity and mortality. The aim of this study was to investigate the incidence and outcome of HA COVID-19 in different specialties across the wards in 18 hospitals belonging to the Helsinki University Hospital (HUH) responsible for secondary and tertiary care of a population of 1.8 million. Design: Retrospective population-based cohort study. Setting: Secondary and tertiary care hospitals. Patients: Inpatients with HA COVID-19 infection. Methods: The HA COVID-19 infections with patient characteristics were retrospectively searched from HUH patient database from 1st October 2021 to 31st March 2022. All positive SARS-CoV-2 nucleic acid amplification tests (NAATs) from any ward were reviewed. The COVID-19 infection was classified as HA if a notification of HA infection was done or SARS-CoV-2 NAAT was positive ≥6 days after hospital admission or medical records revealed a known exposure for COVID-19 during hospital stay. Results: 177 HA COVID-19 infections were retrieved with an incidence of 0.55 per 1000 patient days. Of these patients, 71 (40%) were treated in medicine, 52 (29%) in operative, and 54 (31%) in psychiatric wards, leading to incidences of 0.51, 0.39, and 1.10 per 1,000 patient days, respectively. In association with COVID-19, 16 (23%) in medicine, 3 (6%) in operative, and 1 (2%) patient in psychiatric wards deceased. Of the deceased patients, 16 (80%) had received at least one COVID-19 vaccine. Conclusions: Hospital-acquired COVID-19 infections in omicron era were related to high mortality, especially among patients in medicine wards who also had good vaccination coverage.

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Nosocomial COVID-19 Incidence and Secondary Attack Rates among Patients of Tertiary Care Center, Zurich, Switzerland

Cited by 8 publications

References 13 publications

Identifying Adverse Events in Patients Hospitalized in Isolation or Quarantine Due to COVID-19

Identifying Adverse Events in Patients Hospitalized in Isolation or Quarantine Due to COVID-19

Risk factors for nosocomial COVID-19 in a French university hospital

Incidence and outcome of hospital-acquired COVID-19 infections in secondary and tertiary care hospitals in the era of COVID-19 vaccinations

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