Nosocomial <i>Clostridium difficile</i>-associated diarrhoea in Assiut University Children’s Hospital, Egypt

Faddan, Nagla H. Abu; Aly, Sherin A.; Faddan, Hala H. Abou

doi:10.1179/2046905514y.0000000167

Cited by 8 publications

(4 citation statements)

References 36 publications

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“…Treatment with Pulsatilla Decoction could reduce the relative abundance of Clostridiales . Clostridium difficile (Abu Faddan et al, 2016 ), a species belonging to order Clostridiales, produced multiple toxins which might produce infection and inflammation. These results suggested that Pulsatilla Decoction could modulate the distribution of the intestinal flora in order level to alleviate infection.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Gut Microbiota Between Pulsatilla Decoction and Levofloxacin Hydrochloride Therapy on Escherichia coli Infection

Liu

et al. 2020

Front. Cell. Infect. Microbiol.

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Gut microbiota serves as a critical indicator for gut health during treatment of pathogenic bacterial infection. Both Pulsatilla Decoction (abbreviated to PD, a traditional Chinese medicine compound) and Levofloxacin Hydrochloride (LVX) were known to have therapeutic effects to intestinal infectious disease. However, the changes of gut microbiota after PD or LVX treatment remain unclear. Herein, this work aimed to investigate the changes of intestinal flora after PD or LVX therapy of Escherichia coli infection in rats. Results revealed that PD exhibited a valid therapeutic approach for E. coli infection via the intestinal protection, as well as the inhibited release of IL-8 and ICAM-1. Besides, PD was beneficial to rebuild the gut microbiota via restoring Bacteroidetes spp in the composition of the gut microbiota. Comparatively, LVX treatment promoted the infection and ravaged gut microbiota by significantly decreasing Bacteroidetes and increasing Firmicutes. These findings not only highlight the mechanism of Chinese herbal formula, but extend the application of PD as veterinary medicine, feed additive and pre-mixing agent for improving the production of animal derived foods.

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Section: Discussionmentioning

confidence: 99%

Comparison of the Gut Microbiota Between Pulsatilla Decoction and Levofloxacin Hydrochloride Therapy on Escherichia coli Infection

Liu

et al. 2020

Front. Cell. Infect. Microbiol.

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“…Those aged ≤12 months were the most commonly affected (eight, 47%). The main cause of admission was respiratory disorders (47% of cases) [63].…”

Section: Clostridiun Difficile Infection In Arab Countriesmentioning

confidence: 99%

Clostridium difficile: Infection, diagnosis and treatment with antimicrobial drugs : A review article

Shehabi

Badran

Abu-Khader

2015

int. arab. j antimicrob. agents

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Clostridium difficile infection (CDI) is increasing problem in healthcare, associated with high incidence, mortality, and costs in hospitalized patients. Dramatic increases in the incidence and severity of healthcare-associated C. difficile infection have occurred since the last decade, including elderly population, young adults, pregnant females, infants and children. C. difficile infections are mainly linked to the prolonged use of wide-spectrum antibiotics that disrupt the intestinal microbiota equilibrium. Toxigenic strains of C. difficile commonly produce two clostridial toxins, toxins A (TcdA) and B (TcdB), which are responsible for disease symptoms. Few strains of C. difficile may also produce another more powerful binary toxin associated with high fatality. The clinical manifestations of infection with toxin-producing strains of C. difficile range from symptomless carriage to mild or moderate watery-bloody diarrhea, and few percentage developed fulminant and sometimes fatal pseudomembranous colitis. Complications that have been associated with CDI include dehydration, electrolyte disturbances, toxic megacolon, bowel perforation, hypotension, renal failure, systemic inflammatory response syndrome, sepsis, and death. The most important step in treating CDI is immediately discontinuing use of offending antimicrobial drug. Both metronidazole and vancomycin are equally effective for the treatment of mild CDI, but vancomycin is superior for treating patients with severe C. difficile disease. Recently, fidaxomicin proved to be superior to other drugs in treatment of patients who are at high risk for CDI relapse.

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“…These results shows that measures must be taken against the dissemination of virulent and toxigenic strains in order to avoid diarrheal epidemics linked to these strains. In addition, the frequent isolation of ribotypes constituted a significant overlap, making poultry meat a potential source of C. difficile infection in humans [ 32 – 35 ]. From these data, it could be inferred that consumption of broilers and contaminated chicken meat could be a source of human disease.…”

Section: Discussionmentioning

confidence: 99%

Examining the Extent of Contamination, Antibiotic Resistance, and Genetic Diversity of Clostridioides (Clostridium) difficile Strains in Meat and Feces of Some Native Birds of Iran

Barezi

Shakerian

Rahimi

et al. 2023

BioMed Research International

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Clostridioides (Clostridium) difficile (C. difficile) is one of the essential enteropathogens in humans and livestock and is a severe health threat, according to the Centre for Disease Control and Prevention. Also, antimicrobials are one of the most critical risk factors for C. difficile infection (CDI). The present study examined the infection, antibiotic resistance, and genetic diversity of the C. difficile strains in the meat and feces of some native birds (chicken, duck, quail, and partridge) in the Shahrekord region, Iran, from July 2018 to July 2019. Samples were grown on CDMN agar after an enrichment step. To determine the toxin profile, the tcdA, tcdB, tcdC, cdtA, and cdtB genes were detected via multiplex PCR. The antibiotic susceptibility of these isolates was examined using the disk diffusion method and followed based on MIC and epsilometric test. 300 meat samples of chicken, duck, partridge, and quail and 1100 samples of bird feces were collected from six traditional farms in Shahrekord, Iran. Thirty-five meat samples (11.6%) and 191 fecal samples (17.36%) contained C. difficile. Moreover, five toxigenic samples isolated had 5, 1, and 3 tcdA/B, tcdC, and cdtA/B genes. Out of the studied strains isolated from the 226 samples, two isolates belonging to ribotype RT027 and one isolated RT078 profile related to native chicken feces were observed from chicken sample. The antimicrobial susceptibility testing showed that all the strains are resistant to ampicillin, 28.57% are resistant to metronidazole, and 100% were susceptible to vancomycin. Based on the results, it can be concluded that the raw meat of birds might be a source of resistant C. difficile that poses a hygienic threat to the consumption of native bird meat. Nevertheless, further studies are essential to understand additional epidemiological features of C. difficile in bird meat.

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Nosocomial Clostridium difficile-associated diarrhoea in Assiut University Children’s Hospital, Egypt

Cited by 8 publications

References 36 publications

Comparison of the Gut Microbiota Between Pulsatilla Decoction and Levofloxacin Hydrochloride Therapy on Escherichia coli Infection

Comparison of the Gut Microbiota Between Pulsatilla Decoction and Levofloxacin Hydrochloride Therapy on Escherichia coli Infection

Clostridium difficile: Infection, diagnosis and treatment with antimicrobial drugs : A review article

Examining the Extent of Contamination, Antibiotic Resistance, and Genetic Diversity of Clostridioides (Clostridium) difficile Strains in Meat and Feces of Some Native Birds of Iran

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