Nosocomial Infection Caused by Methicillin-Resistant<i>Staphylococcus aureus</i>in Palestine

Adwan, Kamel; Abu-Hasan, N.; Adwan, Galeb; Jarrar, Naser; Abu-Shanab, Bassam; Abu-Zant, Alaeddin

doi:10.1089/mdr.2005.11.75

Cited by 24 publications

(21 citation statements)

References 14 publications

(22 reference statements)

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“…During the study, MRSA was found to be resistance to ciprofloxacin (65%), trimethoprimsulfamethoxazole (71%), clindamycin (89%) and erythromycin (88%). Similarly, Adwan et al 44 reported that up to 82.1% of nosocomial MRSA isolates were resistant to erythromycin and therefore, the macrolides cannot be considered first line therapy for serious Staphylococcal infections.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Antimicrobial Susceptibility of Methicillin-Resistant Staphylococcus aureus in an Egyptian University Hospital

Taha¹,

Badr²,

El-Morsy³

et al. 2019

J Pure Appl Microbiol

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The relative high burden of morbidity and mortality caused by Staphylococcus aureus (SA) in healthcare and community settings is a major concern worldwide. It can cause invasive infections, sepsis and deaths. Despite progress in methicillin-resistant S. aureus (MRSA) prevention in healthcare settings, there is a critical need for assessment of the problem in both healthcare and community settings. This study was conducted for examining the prevalence, risk factors and antimicrobial susceptibility of MRSA in Mansoura University Hospitals (MUHs), Egypt. Samples were collected from patients in MUHs with clinically suspected nosocomial infections. MRSA isolates were identified by the standard bacteriological methods, biochemical reactions and disc diffusion method as recommended by the Clinical & Laboratory Standards Institute (CLSI), then confirmed by MecA gene PCR. A total of 2006 isolates was obtained. SA (32%) was the most frequently isolated pathogen. MRSA (130 isolates) represented 20% of SA and 6.48 % of all isolates. The mecA PCR identified SA as MRSA in 99.2% of cases. MRSA was isolated with another organism (mostly Gram-negative bacilli) from 40.8% of cases while 59.2% of MRSA was isolated alone. The most important reported risk factors for MRSA infections were prolonged hospital stays, recent antibiotic therapy, ICU admission, indwelling devices and presence of surgical sutures. MRSA was resistant to many antibiotics but sensitive to vancomycin in 99.2% of cases. Minimizing exposure to the risk factors with rapid diagnosis of MRSA infections are essential for early initiation of appropriate antibiotic treatment and limitation of the non-optimal use of glycopeptides and deaths.

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Section: Discussionmentioning

confidence: 99%

Prevalence and Antimicrobial Susceptibility of Methicillin-Resistant Staphylococcus aureus in an Egyptian University Hospital

Taha¹,

Badr²,

El-Morsy³

et al. 2019

J Pure Appl Microbiol

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“…The antimicrobial susceptibility patterns of the MRSA isolates are a cause for concern as an extremely high rate (above 82%) of resistance to penicillin G, erythromycin, clindamycin, ciprofl oxacin, gentamicin, cefotaxime, and sulfamethoxazole-trimethoprim was observed, a fi nding mirrored elsewhere [14,15].…”

Section: Discussionmentioning

confidence: 99%

Molecular characterization of methicillin-resistantStaphylococcus aureusisolates in three different Arab world countries

Sabri¹,

Adwan²,

Essawi³

et al. 2013

European Journal of Microbiology and Immunology

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Molecular characterization of methicillin-resistant Staphylococcus aureus (MRSA) isolates in three different Arab world countries (West Bank of Palestine, Jordan, and Iraq) was the aim of the study presented here. This is done on the basis of spa sequencing and staphylococcal cassette chromosome mec (SCCmec) typing. The majority (92%) of the spa-tested isolates belonged to spa type t932 and possessed the (SCCmec) type III. These data suggest that MRSA clone, which harbors the spa type t932 and (SCCmec) type III, had been transferred throughout the three studied countries.

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“…These practices might, in part, explain previous findings in Palestine that the prevalence of Methicillin-resistant staphylococcus aureus (MRSA) was the highest among isolates associated with upper respiratory specimens [2]. Unfortunately, inappropriate antibiotic practices have been previously reported in both hospital and community settings in Palestine.…”

Section: Af Sawalha / Self-medication With Antibiotics: a Study In mentioning

confidence: 99%

Self-medication with antibiotics: A study in Palestine

Sawalha¹

2008

International Journal of Risk and Safety in Medicine

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Objective: The objective of this study was to investigate self-medication practices with antibiotics among school teachers in Palestine. Methods: A survey was conducted via a structured questionnaire among governmental school teachers regarding their practices and attitude toward antibiotics. All data were entered and analyzed using SPSS 15. Results: A total of 1039 teachers completed and returned the questionnaire; giving a response rate of 64.9%. Respondents were divided as follows: group I (19.4%) were those who used antibiotics through self-medication only, group II (12.4%) used antibiotics by prescription only, group III (44.7%) used antibiotics by self-medication and prescription while those in group IV (23.3%) were those who did not report using antibiotics in the past six months. Antibiotic utilization among respondents was 76.7% in the past six months. Respondents in the 4 groups had comparable demographic characteristics. Respondents in group I were more likely (42.2%) to administer antibiotics to children without medical consultation, store antibiotic leftover (52.3%) for further use, stack antibiotics at home (59.7%) to be used whenever needed and had the least attitude to finish the entire antibiotic course when prescribed to them (59.9%). Across the four groups, male and female respondents had comparable attitude toward antibiotic use except that males tend to store antibiotic leftover more than females while females tend to finish the entire antibiotic course when taken by self-medication more than males. Respondents in groups I and III mainly consulted pharmacists on self-medication and obtained the antibiotics mainly from community pharmacy. Penicillin was the major class utilized by respondent either by self-medication or by prescription in groups I (74.3%), II (70.5%) and III (68.9%). Sore throat was the most common (30.3%) clinical condition that respondents self-treat with antibiotics, followed by symptoms of common cold (24.4%). Conclusion: Our study showed that self-medication practices with antibiotics are common and that most of these practices were inappropriate. These results should trigger health policy makers in Palestine to take action in order to prevent antibiotic misuse. Public awareness about proper use of antibiotics is needed. Furthermore, strengthening pharmacy laws and pharmacy control over non-prescription sale of antibiotics is highly recommended.

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Nosocomial Infection Caused by Methicillin-ResistantStaphylococcus aureusin Palestine

Cited by 24 publications

References 14 publications

Prevalence and Antimicrobial Susceptibility of Methicillin-Resistant Staphylococcus aureus in an Egyptian University Hospital

Prevalence and Antimicrobial Susceptibility of Methicillin-Resistant Staphylococcus aureus in an Egyptian University Hospital

Molecular characterization of methicillin-resistantStaphylococcus aureusisolates in three different Arab world countries

Self-medication with antibiotics: A study in Palestine

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