Nosocomial meningitis in a university hospital between 1993 and 2002

Palabiyikoglu, I.; Tekeli, Emin; Çokça, Fügen; Akan, Özay Arıkan; Ünal, Necmettin; Erberktas, I.; Lale, S.; Kiraz, Selahaddin

doi:10.1016/j.jhin.2005.06.010

Cited by 48 publications

(36 citation statements)

References 9 publications

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“…Other studies have reported S.aureous as the most frequent organism, a lot of results related to nosocomial and post-surgical meningitis [2,10,18,19] . Some other studies have demonstrated Streptococcus pneumonia is the most common pathogen in post-surgical meningitis [6] , however the incidence of S. pneumonia observed more in the children [12] .…”

Section: Discussionmentioning

confidence: 97%

“…Although the nosocomial meningitis is rare, there is a wide range of factors associated with post traumatic meningitis. Palabiyikoglu and colleagues elucidated that traumatic wound infection, post-surgical wound infection and ventriculoperitoneal shunt were associated with PTM [10] . Korinek et al [5] substantiated the aforementioned factors and found other risk factors like CSF leakage, male sex, duration of surgery and neurological operation itself [5] .…”

Section: Introductionmentioning

confidence: 99%

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Post Traumatic Meningitis in Neurosurgery Department

Afshar¹,

Karamoozian²,

Shafei³

2009

American J. of Infectious Diseases

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Problem statement: Post-Traumatic Meningitis (PTM) is a serious complication followed trauma. It sounds to have different pattern and characteristics. The aim of the current study was to determine the characteristics and outcome of PTM in referral neurosurgery department in Iran. Approach: During 5 years period-2003-2008, all records from meningitis patients in neurosurgery department in the unique referral trauma center in Kerman, Iran were evaluated by researchers, retrospectively. The PTM cases were selected and their data registered in the data collection form. The outcome of the disease as live or death considered, too. Analysis was conducted based on outcome and multivariable ANOVA was done to determine factor associated with death in PTM cases. Results: The incidence of PTM in head trauma patients estimated 3.1% (95% CI = 2.5-3.9%). The most frequent cases were male 89.7%. Average of age was 28.4±17.2 years. Klebsiella was the most common organism in CSF culture. Hospital staying time average in these patients was 25.7±15.8 days. Surgery was done for 52 (66.6%) cases. The fatality rate was 24.4%, (95% CI = 15.4-35.4). All death had undergone operation. Multivariable ANAOVA declared that blood sugar and CSF protein differed statistically between two groups, died and survived. Conclusion: PTM is an important phenomenon that has great mortality. Certainly, it needs antibiotic prophylaxis and immediate intervention and preventive services to reduce its morbidity and mortality rate.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Post Traumatic Meningitis in Neurosurgery Department

Afshar¹,

Karamoozian²,

Shafei³

2009

American J. of Infectious Diseases

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“…Son yıllarda ülkemizde ve dünyada yapı-lan çalışmalarda nozokomiyal SSS etkenleri olarak stafilokoklar ve Gram negatif etkenlerin ilk sıraları aldığı gösterilmiştir (11,12,14,15) . Bulut ve ark.…”

Section: Discussionunclassified

“…Palabıyıkoğlu ve ark. (12) 'nın 1993-2002 yılları arasında yaptıkları çalış-mada ise nozokomiyal menenjit etkeni olarak nonfermenter Gram negatiflerin 2000'li yıllara doğru ilk sıralara yükseldiği bildirilmiştir. Wang ve ark.…”

Section: Discussionunclassified

Factors Associated with Mortality in Nosocomial Central Nervous System Infections

Dizbay¹,

Tunçcan²,

Arman³

et al. 2011

ANKEM Derg

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“…1,2,23,32 Various factors that are associated with the development of posttraumatic meningitis include skull fractures, facial fractures (mainly involving the paranasal sinuses), otological injuries, development of CSF fistulas, and pneumocephalus. 6,8,13,15,16,20,25,31 Typically, fractures of the skull or facial bones may lead to the formation of CSF fistulas, which in turn increase the likelihood of meningitis. 25 There are limited data to support an independent association of meningitis with skull fractures, facial fractures, and subsequent CSF leaks.…”

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confidence: 99%

Is posttraumatic cerebrospinal fluid fistula a predictor of posttraumatic meningitis? A US Nationwide Inpatient Sample database study

Sonig¹,

Thakur²,

Chittiboina³

et al. 2012

FOC

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Object Various factors have been reported in literature to be associated with the development of posttraumatic meningitis. There is a paucity of data regarding skull fractures and facial fractures leading to CSF leaks and their association with the development of meningitis. The primary objective of this study was to analyze the US Nationwide Inpatient Sample (NIS) database to elucidate the factors associated with the development of posttraumatic meningitis. A secondary goal was to analyze the overall hospitalization cost related to posttraumatic meningitis and factors associated with that cost. Methods The NIS database was analyzed to identify patients admitted to hospitals with a diagnosis of head injury from 2005 through 2009. This data set was analyzed to assess the relationship of various clinical parameters that may affect the development of posttraumatic meningitis using binary logistic regression models. Additionally, the overall hospitalization cost for the head injury patients who did not undergo any neurosurgical intervention was further categorized into quartile groups, and a regression model was created to analyze various factors responsible for escalating the overall cost of the hospital stay. Results A total of 382,267 inpatient admissions for head injury were analyzed for the 2005–2009 period. Meningitis was reported in 0.2% of these cases (708 cases). Closed skull base fractures, open skull base fractures, cranial vault fractures, and maxillofacial fractures were reported in 20,524 (5.4%), 1089 (0.3%), 5064 (1.3%), and 88,649 (23.2%) patients, respectively. Among these patients with fractures, meningitis was noted in 0.17%, 0.18%, 0.05%, and 0.10% admissions, respectively. Cerebrospinal fluid rhinorrhea was reported in 453 head injury patients (0.1%) and CSF otorrhea in 582 (0.2%). Of the patients reported to have CSF rhinorrhea, 35 (7.7%) developed meningitis, whereas in the cohort with CSF otorrhea, 15 patients (2.6%) developed meningitis. Cerebrospinal fluid rhinorrhea (p < 0.001, OR 22.8, 95% CI 15.6–33.3), CSF otorrhea (p < 0.001, OR 9.2, 95% CI 5.2–16.09), and major neurosurgical procedures (p < 0.001, OR 5.6, 95% CI 4.8–6.5) were independent predictors of meningitis. Further, CSF rhinorrhea (p < 0.001, OR 2.0, 95% CI 1.6–2.7), CSF otorrhea (p < 0.001, OR 2.3, 95% CI 1.9–2.7), and posttraumatic meningitis (p < 0.001, OR 3.1, 95% CI 2.5–3.8) were independent factors responsible for escalating the cost of head injury in cases not requiring any major neurosurgical intervention. Conclusions Cerebrospinal fluid rhinorrhea and CSF otorrhea are independent predictors of posttraumatic meningitis. Furthermore, meningitis and CSF fistulas may independently lead to significantly increased cost of hospitalization in head injury patients not undergoing any major neurosurgical intervention.

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Nosocomial meningitis in a university hospital between 1993 and 2002

Cited by 48 publications

References 9 publications

Post Traumatic Meningitis in Neurosurgery Department

Post Traumatic Meningitis in Neurosurgery Department

Factors Associated with Mortality in Nosocomial Central Nervous System Infections

Is posttraumatic cerebrospinal fluid fistula a predictor of posttraumatic meningitis? A US Nationwide Inpatient Sample database study

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