Nosocomial Methemoglobinemia Resulting from Self-Administration of Benzocaine Spray

Hoffman, Christopher; Abubakar, Hawa; Kalikiri, Pramood; Green, Michael

doi:10.1155/2015/685304

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…ATP provides the energy for muscle contraction, among other things. For erythrocytes to be able to deliver oxygen to the cells, the iron in hemoglobin must be in the reduced state, or Fe 2+ (Hoffman et al, 2015). Under conditions of increasing oxidative stress, there is an increasing probability of Fe 2+ being converted to the ineffective Fe 3+ .…”

Section: Human Studymentioning

confidence: 99%

Antioxidant Activity of Noni Juice in Vitro and in Human Volunteers

West¹

2023

JFR

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Morinda citrifolia (noni) fruit juice has been found to provide a wide range of potential health benefits. Among these are the reduction of free radicals and protection against lipid peroxide DNA damage in heavy cigarette smokers and athletes who had exercised to the point of exhaustion. These benefits have been observed after drinking a beverage containing a blend of noni juice from French Polynesia, Tahitian Noni® Juice (TNJ). To determine if TNJ exerts more immediate antioxidant effects, and under less extreme conditions, in vitro tests and a trial involving healthy young adult men were conducted. In the human study, volunteers drank 200 mL TNJ, orange juice or water following an overnight fast. Blood samples were collected before and 1 hour following ingestion of the beverages. Plasma and red cell lysate (erythrocyte) samples were measured for antioxidant activity potentiometrically. TNJ exhibited high in vitro antioxidant activity in the 2,2-diphenylpicrylhydrazyl (DPPH) radical scavenging, reducing power and lipid hydroperoxide scavenging assays. TNJ also significantly increased mean antioxidant activity in plasma and erythrocytes of healthy volunteers. The effect of TNJ in erythrocytes was approximately 4.6 times greater than that of orange juice. There were no increases observed in the water group. The results of this study reveal that TNJ can provide antioxidant benefits shortly after ingestion and under more everyday conditions, not only in extreme circumstances or when consumed repeatedly.

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Section: Human Studymentioning

confidence: 99%

Antioxidant Activity of Noni Juice in Vitro and in Human Volunteers

West¹

2023

JFR

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show abstract

“…ATP provides the energy for muscle contraction, among other things. For erythrocytes to be able to deliver oxygen to the cells, the iron in hemoglobin must be in the reduced state, or Fe 2+ (Hoffman 2015). Under conditions of increasing oxidative stress, there is an increasing probability of Fe 2+ being converted to the ineffective Fe 3+ .…”

Section: Human Studymentioning

confidence: 99%

Antioxidant activity of Tahitian Noni® Juice in vitro and in human volunteers

West¹

2022

Preprint

View full text Add to dashboard Cite

Morinda citrifolia (noni) fruit juice has been found to provide a wide range of potential health benefits. Among these are the reduction of free radicals and protection against lipid peroxide DNA damage in heavy cigarette smokers and athletes who had exercised to the point of exhaustion. These benefits have been observed after drinking a beverage containing a blend of noni juice from French Polynesia, Tahitian Noni® Juice (TNJ). To determine if TNJ exerts more immediate antioxidant effects, and under less extreme conditions, in vitro tests and a trial involving healthy young adult men were conducted. In this human study, volunteers drank 200 mL TNJ, orange juice or water following an overnight fast. Blood samples were collected before and 1 hour following ingestion of the beverages. Plasma and red cell lysate (erythrocyte) samples were measured for antioxidant activity potentiometrically. TNJ exhibited high in vitro antioxidant activity in the 2,2-diphenylpicrylhydrazyl (DPPH) radical scavenging, reducing power and lipid hydroperoxide scavenging assays. TNJ also significantly increased mean antioxidant activity in plasma and erythrocytes of healthy volunteers. The effect of TNJ in erythrocytes was approximately 4.6 times greater than that of orange juice. There were no increases observed in the water group. The results of this study reveal that TNJ can provide antioxidant benefits shortly after ingestion and under more everyday conditions, not only in extreme circumstances and when consumed repeatedly.

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“…Here we report a case of methemoglobinemia in an adult man that occurred secondary to the use of topical benzocaine for transesophageal echocardiography (TEE) and also discuss the relevant pathophysiology, clinical presentation, and medical management. Though benzocaine-induced methemoglobin is a rare but well-reported adverse event [2], our objective here is to increase further awareness as this is a life-threatening complication secondary to an otherwise safe local anesthetic that is not even administered systemically but topically.…”

Section: Introductionmentioning

confidence: 99%

Methemoglobinemia: A Rare Entity Caused by Commonly Used Topical Anesthetic Agents, a Case Report

Rawla

Raj

2017

J Hematol

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Benzocaine, a topical anesthetic agent, is widely used during short procedures like endoscopy, endotracheal intubation and likewise. Here we report a case of benzocaine spray-induced methemoglobinemia in an adult male patient during the transesophageal echocardiography (TEE) presenting as hypoxia and improved subsequently in the next 2 h on low-dose intravenous methylene blue. Causality assessment of the adverse event was probable, and preventability assessment was unpreventable. The patient was discharged with no further complications at good health. A relevant etiopathology and managing principles are summarized in this case report such that it serves as an awareness to all medical fraternity about this unexpected yet life-threatening adverse drug reaction to an otherwise safe local anesthetic.

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Nosocomial Methemoglobinemia Resulting from Self-Administration of Benzocaine Spray

Cited by 4 publications

References 15 publications

Antioxidant Activity of Noni Juice in Vitro and in Human Volunteers

Antioxidant Activity of Noni Juice in Vitro and in Human Volunteers

Antioxidant activity of Tahitian Noni® Juice in vitro and in human volunteers

Methemoglobinemia: A Rare Entity Caused by Commonly Used Topical Anesthetic Agents, a Case Report

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