Nosocomial Outbreak due to Klebsiella pneumoniae at a Neurosurgery Unit

Sękowska, Alicja; Kamińska, Dorota; Nakonowska, Beata; Gospodarek, Eugenia

doi:10.33073/pjm-2012-042

Cited by 2 publications

References 6 publications

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Mortality Due to Nosocomial Infection with Klebsiella pneumoniae ESBL+

Starzyk-Łuszcz¹,

Zielonka

Jakubik³

et al. 2017

Advances in Experimental Medicine and Biology

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Klebsiella pneumoniae is one of the most important hospital pathogens, particularly concerning the multidrug-resistant strain ESBL. The aim of this study was to evaluate nosocomial infections with K. pneumoniae ESBL in the context of infection location, risk factors, and prognosis. This hospital study was conducted retrospectively and covered a 3 months' period. The infection with K. pneumoniae ESBL was diagnosed in 36 patients (19 women and 17 men) of the mean age of 74.2 ± 14.8 years. The number of infected patients amounted to 2.2% of all patients admitted to Czerniakowski Hospital in Warsaw, Poland, over the study time. Twenty of these patients died (13 women and 7 men), representing 14% of all hospital deaths at the time. The infection with K. pneumoniae ESBL occurred most frequently in the department of internal diseases, and rarely in neurology or intensive care wards. Bacteria was most often isolated from the urine, with the most distinct association between the use of urinary catheters and death (p = 0.019). We conclude that infections with K. pneumoniae ESBL were associated with over 55% mortality and usually occurred in the setting of internal diseases. Deaths due to K. pneumoniae ESBL infection were significantly related to the use of urinary bladder catheters.

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Mortality Due to Nosocomial Infection with Klebsiella pneumoniae ESBL+

Starzyk-Łuszcz¹,

Zielonka

Jakubik³

et al. 2017

Advances in Experimental Medicine and Biology

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Clinical and Molecular Epidemiology of Extended-Spectrum Beta-Lactamase-Producing Klebsiella spp.: A Systematic Review and Meta-Analyses

2015

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Healthcare-related infections caused by extended-spectrum beta-lactamase (ESBL)-producing Klebsiella spp. are of major concern. To control transmission, deep understanding of the transmission mechanisms is needed. This systematic review aimed to identify risk factors and sources, clonal relatedness using molecular techniques, and the most effective control strategies for ESBL-producing Klebsiella spp. A systematic search of PubMed, Embase, and Outbreak Database was performed. We identified 2771 articles from November 25th, 1960 until April 7th, 2014 of which 148 were included in the systematic review and 23 in a random-effects meta-analysis study. The random-effects meta-analyses showed that underlying disease or condition (odds ratio [OR] = 6.25; 95% confidence interval [CI] = 2.85 to 13.66) generated the highest pooled estimate. ESBL-producing Klebsiella spp. were spread through person-to-person contact and via sources in the environment; we identified both monoclonal and polyclonal presence. Multi-faceted interventions are needed to prevent transmission of ESBL-producing Klebsiella spp.

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Nosocomial Outbreak due to Klebsiella pneumoniae at a Neurosurgery Unit

Cited by 2 publications

References 6 publications

Mortality Due to Nosocomial Infection with Klebsiella pneumoniae ESBL+

Mortality Due to Nosocomial Infection with Klebsiella pneumoniae ESBL+

Clinical and Molecular Epidemiology of Extended-Spectrum Beta-Lactamase-Producing Klebsiella spp.: A Systematic Review and Meta-Analyses

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