Nosocomial outbreak of Pantoea agglomerans bacteraemia associated with contaminated anticoagulant citrate dextrose solution: new name, old bug?

Boszczowski, Ícaro; Júnior, João N. de Almeida; Miranda, É.J. Peixoto de; Freire, Maristela Pinheiro; Guimarães, Thaís; Chaves, Cleuber Esteves; Cais, Daiane Patrícia; Strabelli, Tânia Mara Varejão; Risek, Camila; Soares, Robson E.; Rossi, F.; Costa, Sílvia Figueiredo; Levin, Anna S.

doi:10.1016/j.jhin.2011.12.006

Cited by 32 publications

(22 citation statements)

References 8 publications

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“…In the mid-1960s it was identified in nosocomial infections (6, 7). P. agglomerans is the most frequent species associated with human infections (1, 8). Hospital outbreaks due to contamination of anesthetic agent propofol, blood products, parenteral nutrition, and transference tubes used for intravenous hydration have been demonstrated (8, 9, 10).…”

Section: Introductionmentioning

confidence: 99%

Isolation, Identification and Antimicrobial Susceptibility Pattern of Tatumella ptyseos Strains Isolated From Powdered Infant Formula Milk Consumed in Neonatal Intensive Care Unit: First Report From Iran

Mardaneh

Dallal

Taheripoor

et al. 2014

Jundishapur J Microbiol

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Background:Tatumella ptyseos is a rod-shaped, Gram-negative, facultative, and anaerobic bacteria categorized in the Enterobacteriaceae family. It is a rare food-borne opportunistic pathogen which causes neonatal sepsis, bacteremia, and urinary tract infections. T. ptyseos has been also cultured from various food sources around the world.Objectives:It is difficult to determine the source of the infection in the patients (especially newborns) due to low information about the epidemiology of T. ptyseos. The current study aimed to investigate the isolation, identification and antimicrobial susceptibility pattern of T. ptyseos strains from the consumed powdered infant formula milk (PIF) in hospital neonatal intensive care unit (NICU).Materials and Methods:A total of 125 powdered infant formula milk (PIF) samples were purchased from drug stores from June 2011 to March 2012. T. ptyseos was isolated according to food and drug administration (FDA) method. For final confirmation, biochemical testes embedded in API-20E system were used. Drug susceptibility test was performed using the disc diffusion method, according to clinical and laboratory standard institute (CLSI) recommendations.Results:Results of the study showed that, out of 125 samples, T. ptyseos was isolated from four (3/2%) PIF samples. All isolated strains (100%) were resistant to ampicillin, carbenicillin, cotrimoxazole and amoxicillin.Conclusions:The present study was the first report on the isolation and identification of T. ptyseos from PIF in Iran. T. ptyseos are frequently present in various kinds of foods; therefore, further investigation on these samples is required. It is necessary to track the T. ptyseos in a wide variety of foods and individuals especially in immunocompromised people such as human immunodeficiency virus (HIV)-positive patients to reveal the possible routes of transmission of this pathogen to humans. In addition, molecular studies are required to determine the genetic relationship between T. ptyseos strains isolated from different sources.

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Section: Introductionmentioning

confidence: 99%

Isolation, Identification and Antimicrobial Susceptibility Pattern of Tatumella ptyseos Strains Isolated From Powdered Infant Formula Milk Consumed in Neonatal Intensive Care Unit: First Report From Iran

Mardaneh

Dallal

Taheripoor

et al. 2014

Jundishapur J Microbiol

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“…In 2012, Boszczowski et al identified a nosocomial outbreak with P. agglomerans in patients treated with hemodialysis and plasmapheresis. In that study, a possible environmental contamination was considered and continuous education for good quality hand hygiene and rigorous observation of environmental transmission were advised [10]. In another study, high association between bacteremia and gastroesophageal reflux disease was identified [11].…”

Section: Discussionmentioning

confidence: 99%

An unusual cause of peritonitis in peritoneal dialysis patients: Pantoea agglomerans

Kazancıoğlu

Büyükaydın

Iraz

et al. 2014

J Infect Dev Ctries

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Peritonitis is a serious infection and early diagnosis and treatment is mandatory. A variety of microorganisms are identified in these cases and during recent years a new one was included, Pantoea agglomerans. In this case report, a female patient on continuous ambulatory peritoneal dialysis therapy with a peritonitis episode caused by this organism is described. The source of infection was thought to be due to contact of catheter with non-sterile surfaces. In microbiologic culture, this organism was identified and the patient successfully treated with a three week course of gentamicin therapy. The number of reported cases with this organism has increased in last years and various infection localizations and clinical progress patterns have been identified. In peritoneal dialysis patients presenting with peritonitis, this organism must be kept in mind.

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“…The species belonging to this genus are usually isolated from soil, fruits, and vegetables [1][2][3][4], but can be ubiquitously found in host-associated microbiome such as the human gut [5,6] and plant microbiome [7]. Pantoea species can occasionally be involved in human infections and have been recently described as causing nosocomial outbreaks [3,[8][9][10]. The species Pantoea eucrina has rarely been isolated from humans.…”

Section: Introductionmentioning

confidence: 99%

Description of the First Case of Catheter-Related Bloodstream Infection Due To Pantoea eucrina in a Cancer Patient

Lotte

Sindt

Ruimy³

et al. 2018

SN Compr. Clin. Med.

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We describe here the first case of catheter-related bloodstream infection due to Pantoea eucrina in a 23-year-old female patient with colon adenocarcinoma and congenital hypogammaglobulinemia. In May 2018, she was admitted for fever and abdominal pain. Blood cultures withdrawn from peripheral inserted central catheter and periphery revealed the presence of Pantoea eucrina, with differential time of positivity in favor of catheter-related bloodstream infection. Catheter was removed and antibiotic started, with rapid recovery. Species of genus Pantoea are mainly environmental strains and plant pathogens, rarely responsible for human infection. Patient's comorbid conditions and gut microbiota imbalance could have been responsible for such bacteremia. Identification of Pantoea eucrina was performed using the MALDI-TOF technique. Infections due to Pantoea eucrina were probably until recently underestimated, as older methods such as Phoenix frequently lead to false identification.

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Nosocomial outbreak of Pantoea agglomerans bacteraemia associated with contaminated anticoagulant citrate dextrose solution: new name, old bug?

Cited by 32 publications

References 8 publications

Isolation, Identification and Antimicrobial Susceptibility Pattern of Tatumella ptyseos Strains Isolated From Powdered Infant Formula Milk Consumed in Neonatal Intensive Care Unit: First Report From Iran

Isolation, Identification and Antimicrobial Susceptibility Pattern of Tatumella ptyseos Strains Isolated From Powdered Infant Formula Milk Consumed in Neonatal Intensive Care Unit: First Report From Iran

An unusual cause of peritonitis in peritoneal dialysis patients: Pantoea agglomerans

Description of the First Case of Catheter-Related Bloodstream Infection Due To Pantoea eucrina in a Cancer Patient

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