Nosocomial pseudomonas cepacia infection associated with chlorhexidine contamination

Sobel, Jack D.; Hashman, N.; Reinherz, G.; Merzbach, D.

doi:10.1016/0002-9343(82)90176-0

Cited by 85 publications

(35 citation statements)

References 21 publications

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“…This is attributed to the fact that it can contaminate anaesthetics, disinfectants and antiseptics such as chlorhexidine and povidone-iodine, ventilator nebulisers, saline solution and catheters [100][101][102][103][104][105][106][107]. Catheters, especially when they are implanted for long periods of time, can facilitate bacterial colonisation and biofilm formation [108]; their removal in such cases is of great value [102].…”

Section: Evaluation Of the Available Clinical Evidencementioning

confidence: 99%

Therapeutic options for Burkholderia cepacia infections beyond co-trimoxazole: a systematic review of the clinical evidence

Avgeri

Matthaiou

Dimοpoulos

et al. 2009

International Journal of Antimicrobial Agents

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Section: Evaluation Of the Available Clinical Evidencementioning

confidence: 99%

Therapeutic options for Burkholderia cepacia infections beyond co-trimoxazole: a systematic review of the clinical evidence

Avgeri

Matthaiou

Dimοpoulos

et al. 2009

International Journal of Antimicrobial Agents

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“…A recent survey at the Hospital for Sick Children, Toronto, suggested that approximately 40% of a total of 500 CF patients are now colonized with this organism. The infection is believed to spread by nosocomial transmission (4,5) but once acquired, the clinical course is quite variable. Some patients show no particular alteration in the course oftheir disease, some show a mildly accelerated decline, while others succumb to a rapid decline in pulmonary function with fever, elevation oferythrocyte sedimentation rate, leukocytosis, and resistance to antibiotic therapy, culminating in death within several months to a year.…”

mentioning

confidence: 99%

Binding of Pseudomonas cepacia to normal human intestinal mucin and respiratory mucin from patients with cystic fibrosis.

Sajjan¹,

Corey²,

Karmali³

et al. 1992

J. Clin. Invest.

111

108

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Although not as prevalent as Pseudomonas aeruginosa, Pseudomonas cepacia is another opportunistic pathogen which colonizes the lungs of at least some patients with cystic fibrosis. A subgroup of these patients exhibits the "cepacia syndrome", i.e., a rapid clinical deterioration and death within one year. To investigate potential early sites of bacterial attachment, we have measured the specific binding of P. cepacia isolates from cystic fibrosis (CF) sputa to both CF and non-CF mucins purified from respiratory and intestinal secretions, respectively. As shown in microtiter binding assays, clinical isolates from 19/22 patients were found to bind to both mucins, with the highest specific binding exhibited by isolates from eight patients, seven of whom later died with the cepacia syndrome. No differences were observed in the binding capacity of the two (CF versus non-CF) mucins. Binding was specific, saturable, and not influenced by tetramethylurea, a disruptor of hydrophobic associations. Individual sugars were ineffective as hapten inhibitors, as were several lectins. Mucins treated by reduction/alkylation or chloroform/methanol extraction showed enhanced bacterial binding, findings which were attributed to exposure of underlying binding sites. Deglycosylation procedures indicated that mucin receptors for P. cepacia include N-acetylglucosamine and N-acetylgalactosamine, probably linked together as part of core oligosaccharide structures. P. cepacia isolates also bound to buccal epithelial cells, and mucin partially inhibited the binding of those isolates of P. cepacia that also had the ability to bind to mucin. We speculate that specific binding of P. cepacia to secreted mucins may be an early step in the pathogenesis of the cepacia syndrome. (J. Clin. Invest. 1992.89:648-656.)

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“…By that time it had already been demonstrated by bacterial culturing that viable bacteria can be present in benzalkonium antiseptic (6,8), povidone iodine (2, 4, 14, 17), or even chlorhexidine, which was shown not to be a source of contamination here (17). The organisms most frequently observed included Burkholderia cepacia and Enterobacter spp.…”

mentioning

confidence: 78%

An Unexpected Experimental Pitfall in the Molecular Diagnosis of Bacterial Endophthalmitis

et al. 2004

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Nosocomial pseudomonas cepacia infection associated with chlorhexidine contamination

Cited by 85 publications

References 21 publications

Therapeutic options for Burkholderia cepacia infections beyond co-trimoxazole: a systematic review of the clinical evidence

Therapeutic options for Burkholderia cepacia infections beyond co-trimoxazole: a systematic review of the clinical evidence

Binding of Pseudomonas cepacia to normal human intestinal mucin and respiratory mucin from patients with cystic fibrosis.

An Unexpected Experimental Pitfall in the Molecular Diagnosis of Bacterial Endophthalmitis

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