Nosocomial Transmission of Multidrug-Resistant <i>Mycobacterium tuberculosis</i> in Spain

Jv, Rullán; Martínez-Herrera, David I.; Cano, Rocío Garfias; Moreno,; Godoy, Pere; Ef, Peiró; Castell, J; Ibañez, Cecilia; Ortega, A; Ls, Agudo; Pozo, Franco Andres Del

doi:10.3201/eid0202.960208

Cited by 72 publications

(36 citation statements)

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“…By moving treatment into the community, it is possible, without compromising the quality of therapy, to lower costs and reduce the risk of nosocomial spread of multidrug-resistant tuberculosis. [59][60][61] During the past two years, we have expanded the DOTS-Plus model to cover much of Lima. The costs of therapy have continued to drop even as control over the distribution of second-line drugs has been enhanced.…”

Section: Results Discussionmentioning

confidence: 99%

Community-Based Therapy for Multidrug-Resistant Tuberculosis in Lima, Peru

et al. 2003

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Section: Results Discussionmentioning

confidence: 99%

Community-Based Therapy for Multidrug-Resistant Tuberculosis in Lima, Peru

et al. 2003

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“…Similarly, studies in settings where the incidence of tuberculosis is high documented that the majority of cases occur as a consequence of recent transmission (103) and that many of these transmission events are taking place outside households (108). Similar studies have also illuminated the importance of nosocomial (34,39,69,79,81,83), penitentiary (17,102), and casual (54,71) social settings in disease spread. These findings further underscore the epidemiological importance of diagnostic delays (due to both patient health-seeking and health care provider behaviors) and suggest that more rapid diagnosis and initiation of appropriate drug treatment can play an enormous role in interrupting transmission.…”

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confidence: 87%

Mixed-Strain Mycobacterium tuberculosis Infections and the Implications for Tuberculosis Treatment and Control

et al. 2012

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SUMMARY Numerous studies have reported that individuals can simultaneously harbor multiple distinct strains of Mycobacterium tuberculosis . To date, there has been limited discussion of the consequences for the individual or the epidemiological importance of mixed infections. Here, we review studies that documented mixed infections, highlight challenges associated with the detection of mixed infections, and discuss possible implications of mixed infections for the diagnosis and treatment of patients and for the community impact of tuberculosis control strategies. We conclude by highlighting questions that should be resolved in order to improve our understanding of the importance of mixed-strain M. tuberculosis infections.

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“…Multidrug resistance (MDR, resistant to at least INH and RIF) will thus occur mainly in circumstances where treatment is not optimal. Reports of nosocomial outbreaks of MDR-TB in institutions such as hospitals (10)(11)(12)(13) and prisons (14) and in the United States, Europe, and developing countries (15,16) have focused attention on MDR-TB as a major health issue. Infection followed by active MDR-TB in health care workers after exposure to patients with MDR-TB (17)(18)(19), and outbreaks within communities have also been reported (20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Prediction of Drug Resistance in M. tuberculosis: Molecular Mechanisms, Tools, and Applications

2002

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SummaryManagement of Tuberculosis is complicated by the emergence of drug resistant strains of Mycobacterium tuberculosis and this poses a threat to the success of Tuberculosis control programmes. Drug susceptibility testing by culture is time-consuming and technically difficult. It is known that resistance to drugs is due to a number of genomic mutations in specific genes of M. tuberculosis. These mutations in combination with molecular techniques can be used as markers for drug resistance, since drug susceptible isolates lack the corresponding gene mutations. This review focuses on molecular mechanisms, methods and applications as a possible new diagnostic tool for the early molecular detection of drug resistance in M. tuberculosis.

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Nosocomial Transmission of Multidrug-Resistant Mycobacterium tuberculosis in Spain

Cited by 72 publications

References 13 publications

Community-Based Therapy for Multidrug-Resistant Tuberculosis in Lima, Peru

Community-Based Therapy for Multidrug-Resistant Tuberculosis in Lima, Peru

Mixed-Strain Mycobacterium tuberculosis Infections and the Implications for Tuberculosis Treatment and Control

Prediction of Drug Resistance in M. tuberculosis: Molecular Mechanisms, Tools, and Applications

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