The internet and social networking sites play a significant role in the marketing, sale and the distribution of drugs. The internet is being used both as a source of information and communication but also as a tool to disseminate drug-related websites and sell controlled substances without prescriptions. Our review aims to obtain knowledge concerning the profile of the online drug consumer and the determinants of internet preference. PubMed, Google Scholar and Scopus databases were searched without any language limitations by using a set of keywords. For each set of keywords we evaluated all articles providing socio-demographic characteristics of online drug consumers; reasons for purchasing online drugs; risks related to the online shopping of medicaments and features of illicit/legitimate commercial sites. All data has been analysed and compared for these specified clusters. Results report a majority of Caucasian males in their twenties, both in internet users and drug user/abusers. Several studies reported that the men usually perceive less risks, are more likely to turn to the internet as a source of prescription drugs and, subsequently, more likely to buy drugs and illegal substances online. On the other hand, women were noted as more likely to search for health information. The protection of identity by screen pseudonyms, variety and quality of product listings, selection of vendors based on review feedbacks, reduced personal risks, forum activity and the availability of a service for prescriptiononly drugs stimulate the growth and development of both OPs and drug marketplaces.